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A release modulator , or neurotransmitter release modulator , is a type of drug that modulates the release of one or more neurotransmitters . Examples of release modulators include monoamine releasing agents such as the substituted amphetamines (which induce the release of norepinephrine , dopamine , and/or serotonin ) and release inhibitors such as botulinum toxin A (which inhibits acetylcholine release by inactivating SNAP-25 , thereby preventing exocytosis from occurring).
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Amino acids and similar/related
Amino acids and related: GABA receptor modulators
GABAA receptor positive modulators
GABA metabolism and transport modulators
GHB receptor modulators
Glutamate metabolism and transport modulators
Glycine receptor modulators
Ionotropic glutamate receptor modulators
Metabotropic glutamate receptor modulators
Monoamines: Adrenergic receptor modulators
Dopamine receptor modulators
Histamine receptor modulators
Melatonin receptor modulators
Monoamine metabolism modulators
Monoamine neurotoxins
Monoamine releasing agents
Monoamine reuptake inhibitors
Serotonin receptor modulators
hTAAR modulators
Acetylcholine: Acetylcholine metabolism and transport modulators
Muscarinic acetylcholine receptor modulators
Nicotinic acetylcholine receptor modulators
Others: Imidazoline receptor modulators
Purine receptor modulators
Sigma receptor modulators
Thyroid hormone receptor modulators
Lipids
Eicosanoids: Cannabinoid receptor modulators
Leukotriene signaling modulators
Prostanoid signaling modulators
Phospholipids: Lysophospholipid signaling modulators
PAF receptor modulators
Steroids: Androgen receptor modulators
Estrogen receptor modulators
Glucocorticoid receptor modulators
Mineralocorticoid receptor modulators
Progesterone receptor modulators
Steroid metabolism modulators
Other nuclear receptors: Aryl hydrocarbon receptor modulators
Estrogen-related receptor modulators
FXR and LXR modulators
PPAR modulators
Retinoid receptor modulators
Vitamin D receptor modulators
Xenobiotic-sensing receptor modulators
Peptides/proteins
Peptides: Angiotensin receptor modulators
GH /IGF-1 axis signaling modulators
GnRH and gonadotropin receptor modulators
Melanocortin receptor modulators
Neurokinin receptor modulators
Opioid receptor modulators
Oxytocin and vasopressin receptor modulators
Cytokines: Cytokine receptor modulators
Chemokine receptor modulators
Interleukin receptor modulators
TNF receptor superfamily modulators
Others and non-receptor
Ion channels: Ion channel modulators
TRP channel modulators
Transporters: Sodium-glucose transporter modulators
Symporter inhibitors
Others: Nitric oxide signaling modulators