SNRPA1

SNRPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A9N
Identifiers
Aliases	SNRPA1, Lea1, small nuclear ribonucleoprotein polypeptide A', U2A'
External IDs	OMIM: 603521 MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,295,282 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,724,335 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; adrenal gland; ; anterior pituitary; ; testicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	U2 snRNA binding; GO:0001948 protein binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; small nuclear ribonucleoprotein complex; nucleus; U2 snRNP; nucleoplasm; nuclear speck; nuclear body; U2-type precatalytic spliceosome; U2-type catalytic step 2 spliceosome; viral nucleocapsid;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; interleukin-12-mediated signaling pathway; spermatogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6627
	68981
	ENSG00000131876
	ENSMUSG00000030512
	P09661
	P57784
	NM_003090
	NM_021336
	NP_003081
	NP_067311
	Wikidata
View/Edit Human	View/Edit Mouse

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^[5]^[6]

Interactions[]

SNRPA1 has been shown to interact with CDC5L.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131876 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.
^ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading[]

Ohno M, Kataoka N, Shimura Y (December 1990). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Research. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kjems J, Sharp PA (August 1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". Journal of Virology. 67 (8): 4769–76. doi:10.1128/JVI.67.8.4769-4776.1993. PMC 237863. PMID 8331728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
Price SR, Evans PR, Nagai K (August 1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID 9716128. S2CID 204999419.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, et al. (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (May 1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
Lundin M, Mikkelsen B, Gudim M, Syed M (March 2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine Biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961. S2CID 20060370.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131876 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2928112-5] Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.

[entrez-6] "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".

[pmid11101529-7] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

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v t RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle