SNX15

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SNX15
Identifiers
AliasesSNX15, HSAF001435, sorting nexin 15
External IDsOMIM: 605964 MGI: 1916274 HomoloGene: 12294 GeneCards: SNX15
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_147777
NM_013306

NM_026912

RefSeq (protein)

NP_037438
NP_680086

NP_081188

Location (UCSC)Chr 11: 65.03 – 65.04 MbChr 19: 6.17 – 6.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.[5][6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.[6]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110025 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024787 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079. S2CID 31092568.
  6. ^ a b "Entrez Gene: SNX15 sorting nexin 15".

Further reading[]


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