SNX27

SNX27
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HAS
Identifiers
Aliases	SNX27, MRT1, MY014, sorting nexin family member 27, sorting nexin 27
External IDs	OMIM: 611541 MGI: 1923992 HomoloGene: 12797 GeneCards: SNX27
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,699,091 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,490,023 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; putamen; ; corpus callosum; ; occipital lobe; ; cerebellum; ; internal globus pallidus; ; subthalamic nucleus; ; cerebral cortex; ; nucleus accumbens; ; mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; GO:0001948 protein binding; phosphatidylinositol binding; lipid binding;
Cellular component	early endosome membrane; membrane; nucleoplasm; retromer complex; early endosome; immunological synapse; WASH complex; cytoplasm; endosome; cytosol;
Biological process	establishment of natural killer cell polarity; endosome to lysosome transport; endosomal transport; protein transport; intracellular protein transport; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	81609
	76742
	ENSG00000143376
	ENSMUSG00000028136
	Q96L92
	Q3UHD6
	NM_030918; NM_001330723
	NM_001082484; NM_029721
	NP_001317652; NP_112180
	NP_001075953; NP_083997
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin family member 27, also known as SNX27, is a human gene.^[5]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143376 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028136 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SNX27 sorting nexin family member 27".

Further reading[]

Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (July 2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143376 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028136 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SNX27 sorting nexin family member 27".

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[5]

v t Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX8 SNX9 SNX18
SNX-PX	SNX3 SNX21
SNX-Other	SNX13 SNX15 SNX17 SNX23 SNX26 SNX27 SNX28
Related articles	PX domain BAR domain Retromer