Scooby-Doo and Guess Who?

After Mystery Inc. solves the mystery of the Bee Man of Alcatraz, they are flown to Florida where Shaggy is to caddy for Houston Rockets basketball player and bowling fan Chris Paul at a charity golf event to raise money for a struggling arts school, which is on the brink of going bankrupt because of a swamp monster causing trouble for the tournament.

• Villain: Swamp Monster/The caddy

Mystery Inc. receives a call from Chambersburg, Pennsylvania, a battlefield nearby Gettysburg, Pennsylvania, to solve the mystery of ghost zombie Civil War soldiers only to bump into The Funky Phantom crew. Although both mystery solving teams get into subsequent conflicts until the Ghost of Abraham Lincoln suggests they should work together and save the mystery for once and for all.

• Villain: Ghost Sergeant/Jebb

An egg that was delivered to Peebles' Pet Supply Mega-Store hatches into a fish monster and makes off with Mr. Peebles. Later, Scooby and the gang arrive at the crime scene and rescue Mr. Peebles' intern, Wanda Sykes, who is helping to save a bunch of animals up for adoption in a pet supply store. Now, our heroes and Wanda must not only save the store and the animals, but their own lives. As Mystery Inc. and Wanda work to solve the mystery, they also have an encounter with Magilla Gorilla.

• Villain: Fish Monster/Mr. Peebles

When Scooby and the gang are taking a tour of London, they run afoul of horrible screaming skulls of English legend. They team up with a man who claims to be none other than Sherlock Holmes. Also, during this time, he refers to Velma as Dr. Watson and Shaggy as Mrs. Hudson.

• Villains: Screaming Skulls/The Beefeater and the security guard

In London, Mystery Inc. visits Ricky Gervais when a cat mummy comes unannounced from his door with a connection with the Egyptian goddess Bast. At this rate, the gang agrees to prevent the statue of Bast from falling into the wrong hands.

• Villain: Cat Mummy/The antique dealer

While on vacation in Greece, Mystery Inc. gets caught in a one-on-one scrimmage between a Minotaur and Wonder Woman. Although Scooby-Doo takes a liking to Wonder Woman, Daphne and Velma are the only ones elected to assist Wonder Woman in taking down her latest target, leaving Shaggy and Fred feeling left out.

• Villain: Minotaur/The curator

When Mystery Inc. accepts the invitation from reclusive millionaire Hugo Hauser to spend one night in the haunted Savannah Hotel in Las Vegas before its controlled demolition, they find that they're not alone. Magicians Penn & Teller have also accepted the challenge as they contend with the Ghost of Madds Markson and his monster.

• Villains: Ghost of Madds Markson, Madds Markson Monster, and Hugo Hauser/Teller

When a desperate Steve Urkel (Jaleel White reprising his famous character from Family Matters) turns to Mystery Inc. for help on tracking down his Urkel-Bot in Chicago, they stumble onto a deeper mystery with the appearance of the Technomancer who has the ability to control all robots!

• Villain: The Technomancer/The janitor

When Scooby and Shaggy compete in a fast food-eating/racing competition held by Doc Tally's fast food chain as part of its 70th anniversary, they meet their ultimate challenge eating against comedian Jim Gaffigan while contending with the Spectral Speedster who is trying to stop the contest from finishing.

• Villain: Spectral Speedster/Bill Tally

Driving through the Rocky Mountains, the Mystery Inc. gang stumbles upon a stowaway in the form of "Weird Al" Yankovic who warns them about a horrible unspecified dinosaur raining relentless destruction on his local accordion sleep away camp alongside another unspecified dinosaur.

• Villains: Two Dinosaurs/Pete and Pete

In Palm Springs after Mystery Inc. receives a call from singer-songwriter Sia, she presents them a story involving an infamous jewel thief that has taken the shape of Sia as a ghostly doppelgänger that steals countless diamonds, landing Sia in hot water with the authorities.

• Villain: Sia Doppelgänger/Sia's trainer

In Atlanta, Shaggy and Scooby take the gang to meet their good friend Kenan Thompson who is preparing to broadcast his very own telethon for the first time in history. When a Ghost Clown named Pazzo attacks, Mystery Inc. must help Thompson save the telethon.

• Villain: Pazzo the Ghost Clown/AJ Dobbs

After Daphne's "uncle" Alfred Pennyworth gets kidnapped by Man-Bat, it is up to Batman to get him back with a little help from Mystery Inc. While it was originally suspected that Kirk Langstrom became Man-Bat again, Batman discovers that he is still incarcerated at Arkham Asylum meaning that someone else is posing as Man-Bat.

• Villain: Man-Bat/Joker

While driving through snowy mountains, Mystery Inc. comes across a remote university where they meet Whoopi Goldberg who is a student at the university after having previously protrayed a psychic. Here, the gang must stop the university from closing before Whoopi can graduate, all while dealing with the Nightmare Ghost.

• Villain: The Nightmare Ghost/The cafeteria lady
• Note #1: This episode premiered on September 24, 2019 on Boomerang Italy.^[5]
• Note #2: Whoopi mentioning that she previously portrayed a psychic is a reference to her role of Oda Mae Brown from Ghost.

While in Japan, the gang helps Mark Hamill rescue his old high school drama teacher Mr. Berle who was kidnapped by a Fox Monster. Investigating the scene of the crime reveals a secret basement below the floor and the monster itself, who traps them under a pile of collapsing rubble. Hamill convinces Scooby to dig them out using a "Jedi Mind trick", leading them straight into an underground tunnel and Fox Monster prints. The mystery only deepens when the monster's footprints lead to an old Japanese temple, rumored to house an ancient and valuable sword still hidden somewhere inside to this day.

• Villain: Fox Monster/Coach Roachner

Barry Allen wants to hang out with his favorite eating buddies Shaggy & Scooby at Big Belly Burger more often, but can't due to them always having to leave to help solve mysteries. Deciding to give the gang a little help as the Flash, he quickly steps on their toes by solving the mysteries too fast and incarcerating the villains at Iron Heights Penitentiary, which leads to mounting tensions amongst the group. Flash agrees to slow things down and run at 'normal speed', pretending to be in mortal danger while everyone else runs for their lives. Meanwhile, in the background, a plot by a giant living teddy bear unfolds to force Flash to reveal his secret identity to the world.

• Villain: Giant Teddy Bear/Trickster
• Note: Other classic villains and their identities, in order of appearance ~ Miner Forty-Niner from "Mine Your Own Business"^[l], the Ghost of Captain Cutler/Captain Cutler from "A Clue for Scooby-Doo", the Spooky Space Kook/Henry Bascomb from "Spooky Space Kook", the Snow Ghost/Mr. Greenway from "That's Snow Ghost", the Ghost of Redbeard/C.L. Magnus from "Go Away Ghost Ship", the Black Knight/Mr. Wickles from "What a Night for a Knight", the Witch from "Which Witch is Witch?"^[m], the Witch Doctor/Buck Masters from "Decoy for a Dognapper", the Phantom/Bluestone the Great from "Hassle in the Castle", Charlie the Robot from "Foul Play in Funland", and The Creeper/Mr. Carswell from "Jeepers, It's the Creeper".

The gang investigates a haunted estate belonging to deceased Hollywood Director Cecil D. Darrington (based on Cecil B. DeMille) at the request of George Takei who is currently serving as a tour guide. The house's true owner is currently unknown and is going to be seized by the government within a few weeks before being auctioned off to the highest bidder. To make matters worse, suits of armor are being brought to life by the Ghost Knight of Duke Doom-Bringer, eventually drawing out the house's rightful owner....the kooky and reclusive Darla Darrington.

• Villain: The Ghost of The Doom Bringer/Jimmy the Gardener

Scooby surprises Shaggy by secretly entering him into a poetry slam against Halsey, with the winner being awarded an antique brass key to the city. The poetry slam is interrupted when a Gator Man Monster attacks, stealing the key and escaping with it, but not before an impression of the key is made into a burrito stuck to Scooby's stomach. Using the impression, they are able make a replica with a symbol on the key leading them to the mysterious New York Underground, a strange cafe where patrons pay for food with poetry, the Keeper of Knowledge, and the mysteries that lie beyond.

• Villain: Gator Man Monster/The poetry slam promoter

Mystery Inc. is in Sicily tracking down a Fire Monster from Mount Etna that is apparently hunting Steve Buscemi, currently in the country visiting his cousins Nana Buscemi and Paolo Buscemi. On top of this, everyone in Sicily thinks he is a vicious gangster with Steve constantly trying to explain he's just an actor with those roles being character he portrayed in his films to no avail. In addition, he must also face and overcome his greatest fear....chipmunks!

• Villain: Fire Monster of Mount Etna/Nana Buscemi

Scooby and the gang are hired to deliver a creepy doll named Crazy Karl to a ventriloquist competition by the organizer of the event named Baz Bozzington. Jeff Dunham & Walter alongside Darci Lynne Farmer & Petunia are both attending as celebrity judges when Karl seemingly comes to life, attacking a nearby security guard. Complicating matters is the run down motel they are staying in where both the owner and her son want to make Petunia and Walter a permanent part of their doll collection.

• Villain: Crazy Karl (performed by Baz Bozzington)
• Note: This episode draws inspiration from the Hollywood films Child's Play and Psycho.

Maddie Ziegler has won a dance studio in a dance competition under the condition it be reopened or else the city will confiscate the property and demolish it to make way for a parking lot. Making things more difficult is the ghost of the previous owner, who died 30 years prior, wreaking havoc on the building preventing the studio from re-opening. Daphne is invited by Maddie during her latest attempt to re-open, but the gang arrive only to find the aftermath of the latest disaster. Maddie's only hope of appeasing the ghost is an impossibly complicated dance move called "The Zorbrinski Triangle", a move so difficult, only Madam Zorbrinski herself has ever done it.

• Villain: The Ghost of Madam Zorbrinski/Madam Zorbrinski
• Note: End credits title her as 'Madam Zorbinsky', even though it is pronounced Zorbrinski throughout the entire episode. It is even spelled out as such in animated 'subtitles' at one point during the episode; appearing on screen under a non-English speaker.

Jeff Foxworthy is hired as a truck driver to transport a house known as Wainsly Hall to its new location before a six lane interstate is built on top of the land. Unfortunately, it is haunted by the Wedding Witch, preventing its removal. According to legend, it is the ghost of a woman named Lenora Wainsly who was left at the altar by famous chef Bayard B. Beauregard. Her self-depression and self-loathing supposedly caused her to turn into the witch and curse the property. Now Mystery Inc. and Jeff must get rid of the Wedding Witch of Wainsly Hall so that the house can be relocated.

• Villain: The Wedding Witch of Wainsly Hall/The food truck chef

At the request of Malcolm McDowell, Mystery Inc. travels to his estate just outside Santa Barbara, California in order to help solve the mystery of the Chronobeast and why it is pursuing him. While filming a Hollywood movie about time travel decades prior, he became deeply interested in the theoretical physics behind actual time travel in real life, cracking the code after many years of research. He escorts them into his secret underground lab before showing off his time machine which is made in the form of a pedal powered carousel featuring antique style "Big Wheel" bicycles on the outer track. Velma barely has time to get a call from her future self before the Chronobeast is hot on their heels, leaving the time machine as their only route of escape.

• Villain: Chronobeast/Malcolm McDowell
• Note: The movie referenced in this episode is Time After Time with Malcolm building a remote for his lab in the form of an antique brass pocket watch remarkably similar to the one belonging to Jack the Ripper in the film.

A mysterious package from an anonymous fan arrives for Hex Girl Thorn containing the cursed guitar of Ester Moonkiller. Thorn decides to use it in their concert later that night in Cincinnati, having one of their roadies, Tiny, tune it in time for the show. Tuning and then playing said guitar causes Tiny to go Ballistic, trashing everything in site at Thorn's house, and later backstage at the concert. With Daphne doing their makeup, the gang is close at hand to help wrangle him in before being passed off by the Hex Girls as "Rock and Roll". The Ghost of Ester Moonkiller appears on stage to curse everyone at the concert, with both Thorn and Luna's personalities becoming polar opposites of their normal selves after playing the cursed guitar, threatening to end their careers.

• Villain: The Ghost of Ester Moonkiller/Xander

In a special Broadway musical-like episode, Mystery Inc. are attacked by a werewolf jumping on top of the Mystery Machine, causing them to crash into the nearby Hudson river. Christian Slater sees them passing nearby, saw the logo on the van & winds up hiring them to track down said Werewolf....a Werewolf with a history. At Slater's original senior prom decades ago, the Werewolf attacked and destroyed it, thus prompting the makeup prom currently being held at his alma mater with the Werewolf looming yet again. As Mystery Inc. looks for the Werewolf, they must also contend with a mysterious woman with a past.

• Villain: Werewolf/Christian Slater

Velma and the gang are invited to help Bill Nye the Science Guy test his new experimental space voyager but things turn sour when they are met with only eerie silence and the missing crew of the multi-national space station. They follow the sound of uneven tapping to an electronically locked door with Bill & Velma recognizing it as Morse code. Using the tapped out message, Nye enters the code into the keypad opening the door to reveal Neil deGrasse Tyson. Quickly explaining the monster of the week, a giant Tardigrade (or water bear) appears shortly after, threatening not only the mission, but the entire station as well.

• Villains: Tardigrade Monster/Jacques-Pierre and Pierre-Jacques

Daphne takes the gang to see her celebrity bestie Kacey Musgraves in Nashville where she is performing and a phantom of a man named Tallis Taggert is on the loose, attacking artists he does not like.

• Villain: Phantom of Tallis Taggert/John Lupointe

Mystery Inc. together with Morgan Freeman investigate an old prison, abandoned for 100 years for purportedly being haunted by the Ghost of Jean Lebeau.

• Villains: Ghost of Jean Lebeau/Jeremy and Jeanene Snickersen

Mystery Inc. and Kristen Schaal investigate a haunted hospital with the ghost of a 1950s doctor named Phineas Phrag.

• Villain: Phineas Phrag Monster/Big Bob McAllister

A tree monster called the Gnarled One attacks Shaggy and Scooby-Doo when they are at a hot dog eating contest with Joey Chestnut.

• Villain: The Gnarled One/Big Eddy Eats

While in Paris during Fashion Week, the gang helps model Gigi Hadid after a gargoyle attacks.

• Villain: Gargoyle/Cache Blanc

Shaggy and Scooby do the unexpected and welcome a visit to a haunted castle in Germany because famous chef Alton Brown will be there. They must also contend with a monster made by the known mad food scientist Dr. Frankenfooder.

• Villain: Frankenfooder Monster/Alton Brown

Mystery Inc. runs into Tim Gunn while investigating the sighting of an elevator operator ghost that is haunting the Dergfall Boldman Department Store.

• Villain: Elevator Operator Ghost/Marla

Mystery Inc. heads to Austria for the International Ice Games, where they meet figure skating champion Tara Lipinski. During this time, they must deal with a snow monster called the Snow Devil.

• Villain: Snow Devil/Johann Stever

A defrosted caveman scares up the slopes on the Rocky Mountains where Mystery Inc. meets gold medalist snowboarder Chloe Kim.

• Villain: Caveman/The ski instructor

A robot sabotages the opening of a boxing museum created by boxing pro Laila Ali.

• Villain: Robot (tampered and controlled by the caterer)

Arriving at a haunted Thraber Estate, Shaggy and Scooby-Doo meet with their friend Liza Koshy. As they take part in Liza's fast-paced Internet videos, they must also contend with the attacks caused by the Ghost of Charles M. Thraber.

• Villain: Ghost of Charles M. Thraber/The caretaker

A mysterious invitation to a baseball game allows a chance encounter between Mystery Inc. and rapper Macklemore, the latter of whom is being attacked by a ghostly mascot.

• Villains: Ghost Mascot/Macklemore and Bevin

Sandy Duncan is making a new Jekyll and Hyde movie only for the set to be attacked by a real-life Hyde monster.

• Villain: Hyde Monster/Tabitha
• Note: This episode is a callback to The New Scooby-Doo Movies episode "Sandy Duncan's Jekyll and Hyde" which had a similar plot that also involved Sandy Duncan, a similar Mr. Hyde, and a homage to the character Zalia Z. Fairchild who was the culprit in the original episode.

Alex Trebek hosts an episode of Jeopardy! featuring Velma and Shaggy competing against a robot named Max Kilobyte who goes on a rampage against anyone that looks like they might cause him to lose the game.

• Villain: Max Kilobyte (hacked and controlled by the cameraman)
• Note: The robot is a reference to Jeopardy! The IBM Challenge, a real-life 2011 match where champions Ken Jennings and Brad Rutter competed against IBM's Watson computer. Episode produced under license from Sony Pictures Television (which owns the Jeopardy! franchise). In addition, the episode premiered on November 13 as a posthumous tribute to Trebek who died on November 8, 2020. Real-life announcer Johnny Gilbert also was involved in the episode.

When Fred, Daphne, and Velma are kidnapped by three Mud Men at a diner, Shaggy and Scooby must team up with Axl Rose to save their friends.

• Villain: Mud Men/The cook, the waitress, and the janitor
• Note: This episode was dedicated in loving memory to both Joe Ruby and Ken Spears who were the creators of the Scooby-Doo franchise and the founders of Ruby-Spears Productions, as they died in 2020.

Jason Sudeikis leads the gang on a treasure hunt through the Amazon rainforest where they meet a humanoid snake monster called El Hombre Serpiente.

• Villain: El Hombre Serpiente/Shoe store clerk

A sculpture monster threatens to sabotage the opening of Lucy Liu's art show, so she enlists the gang's help.

• Villain: Sculpture Monster/Jimmy the Pidgeon

The gang investigates a hardware store after a dinner with Sean Astin turns into an adventure to return a lost key ring. The gang quickly realizes that a plant monster is also after the key ring, and they must keep it from the creature at all costs.

• Villain: Green Man Monster/Garden department lady

The gang celebrates Scooby-Doo's birthday on a yacht with Cher. Things become oddly familiar when a pair of shark men attack Cher's boat and the gang has to solve the mystery.

• Villain: Shark Men/Captain Kirby and First Mate Nash

The gang encounters a giant gorilla on a rampage while bumping into Jessica Biel in the jungle.

• Villain: Giant Gorilla/A real gorilla (trained by Joyce Dranders)

Reverend Run needs the gang's help to renovate a youth center haunted by the spirits of two famous musicians.

• Villains: Ghost of Tabb Tatters and Skeleton of Bones McCann/The librarian

Billy Dee Williams teaches the gang how to be cool at his "Cool School." When a pterodactyl suddenly appears, the gang and Billy have to stop the creature.

• Villain: Pterodactyl/Kathy Kavendish III

The gang helps Terry Bradshaw solve the mystery of an alien at his farm.

• Villain: Space Alien/Paranormal investigator

Daphne introduces the gang to her friend Frank Welker, and his friends Grey Griffin, Matthew Lillard and Kate Micucci, who are filming a television show about four mystery solving teens and a talking dog. Familiar monsters begin kidnapping the voice actors one by one, and the gang must devise a plan to rescue them.

• Villains: The Ghost of Captain Cutler/Grey Griffin, Charlie the Robot/Frank Welker, The Ghost of Redbeard/Matthew Lillard, and The Creeper/Kate Micucci

When Blue Falcon is turned to stone by Medusa at an art museum, Scooby-Doo has to become Dog Wonder while Dynomutt takes Blue Falcon's place. Along with the rest of the gang, the duo have to stop Medusa in order to rescue Dynomutt's partner.

• Villain: Medusa Monster/Timothy Smallbottoms

The gang tests out Carol Burnett's new virtual reality movie world, but things become far too realistic than they expected when a monster attempts to sabotage the simulations.

• Villain: Ghost Monster/Gemma (assisted by Tammy, Tod and Cal)