Small Cajal body specific RNA 13

Small Cajal body specific RNA 13
Small Cajal body specific RNA 13
	Predicted secondary structure and sequence conservation of SCARNA13
Identifiers
Symbol	SCARNA13
Alt. Symbols	U93
Rfam	RF00231
Other data
RNA type	Gene; snRNA; snoRNA; scaRNA
Domain(s)	Eukaryota
GO	GO:0006396 GO:0015030 GO:0005730
SO	SO:0000275
PDB structures	PDBe

In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.^[1]

U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs.^[2] U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5.^[2]^[3]^[4]

References[]

^ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
^ ^a ^b Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002). "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. doi:10.1093/nar/gkf592. PMC 135803. PMID 12409454.
^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.

External links[]

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[pmid12032087-1] Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.

[pmid12409454-2] Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002). "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. doi:10.1093/nar/gkf592. PMC 135803. PMID 12409454.

[pmid16381836-3] Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.

[pmid16373490-4] Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.

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