Sodium orthovanadate

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Sodium orthovanadate
Na3VO4dihydrate.tif
Names
IUPAC name
Sodium vanadate(V)
Other names
Sodium vanadium oxide
Identifiers
  • 13721-39-6 (anhydrous) checkY
3D model (JSmol)
ChEMBL
ECHA InfoCard 100.033.883 Edit this at Wikidata
RTECS number
  • YW1120000
UNII
  • InChI=1S/3Na.4O.V/q3*+1;;3*-1;
  • [O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]
Properties
Na3VO4
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm3, solid
Melting point 858 °C (1,576 °F; 1,131 K)
22.17 g/100 mL
Solubility insoluble in ethanol
Structure
cubic
Thermochemistry
164.8 J/mol K
190 J/mol K
Std enthalpy of
formation (ΔfH⦵298)
 −1757 kJ/mol
Hazards
Main hazards Harmful.
NFPA 704 (fire diamond)
3
0
0
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
LD50 (median dose)
 330 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Sodium orthovanadate is the inorganic compound with the chemical formula Na3VO4·2H2O (sodium orthovanadate dihydrate). It is a salt of the VO3−
4 oxyanion. It is a colorless, water-soluble solid.[2]

Synthesis and structure[]

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:

V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O

The salt features tetrahedral VO3−
4 centers linked to octahedral Na+ sites.[3]

Condensation equilibria[]

Like many oxometalates, orthovanadate is subject to a number of reactions, which have been analyzed by 51V NMR studies. At high pH, VO3−
4 ions exist in equilibrium with HVO2−
4.[4] At lower pH's, condensation ensues to give various polyoxovanadates. Ultimately, decavanadate is formed.[5]

Biochemistry[]

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates.[6][7] It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases,[8] and its inhibitory effects can be reversed by dilution or the addition of ethylenediaminetetraacetic acid (EDTA).[9]

Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.[8]

References[]

  1. ^ http://www.sciencelab.com/msds.php?msdsId=9925008
  2. ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 978-0-08-037941-8.
  3. ^ Kato, K.; Takayama-Muromachi, E. (1987). "Die Struktur des Trinatriumvanadattrihydrats" [The structure of trisodium vanadate trihydrate] (PDF). Acta Crystallogr. C43 (6): 1030–1032. doi:10.1107/S0108270187093120.
  4. ^ Rehder, D.; Polenova, T.; Bühl, M. (2007). Vanadium-51 NMR. Annual Reports on NMR Spectroscopy. 62. pp. 49–114. doi:10.1016/S0066-4103(07)62002-X. ISBN 9780123739193.
  5. ^ Klemperer, W. G.; Yaghi, O. (1983). "Tetrabutylammonium Trihydrogen Decavanadate(V)". Inorg. Synth. 27: 83. doi:10.1002/9780470132586.ch15.
  6. ^ Korbecki, Jan; Baranowska-Bosiacka, Irena; Gutowska, Izabela; Chlubek, Dariusz (2012). "Biochemical and medical importance of vanadium compounds" (PDF). Acta Biochim. Pol. 59 (2): 195–200. doi:10.18388/abp.2012_2138. PMID 22693688.
  7. ^ Crans, D. C.; Chatterjee, P. B. (2013). "Vanadium biochemistry". In Reedijk, Jan; Poeppelmeier, Kenneth (eds.). Comprehensive Inorganic Chemistry II: From Elements to Applications. Comprehensive Inorganic Chemistry II. 3. pp. 323–342. doi:10.1016/B978-0-08-097774-4.00324-7. ISBN 978-0-08-097774-4.
  8. ^ a b "Sodium orthovanadate" (PDF). Sigma-Aldrich. Retrieved September 7, 2018.
  9. ^ Biolabs, New England. "Sodium Orthovanadate (Vanadate) | NEB". www.neb.com. Retrieved 2018-09-07.

See also[]

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