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Transforming growth interacting factor (TGIF) is a potential repressor of TGF-β pathways in myometrial cells.[1] Expression of TGIF is increased in uterine leiomyoma compared with myometrium.[1]
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Type I
ALK1 (ACVRL1 )
Decoy receptors: Dalantercept
ALK2 (ACVR1A )
Agonists: Activin (A , B , AB )
AMH (MIS)
Avotermin
BMP (5 , 6 , 7 , 8A , 8B )
Eptotermin alfa
TGFβ (1 , 2 , 3 )
ALK3 (BMPR1A )
Agonists: AMH (MIS)
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B )
Dibotermin alfa
Eptotermin alfa
ALK4 (ACVR1B )
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )
ALK7 (ACVR1C )
Type II
TGFβR2 BMPR2
Antagonists: Inhibin (A , B )
ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )
Myostatin (GDF8)
Nodal
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
ACVR2B
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 6 , 7 )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
AMHR2 (AMHR )
Type III
Unsorted
Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)