From Wikipedia, the free encyclopedia
I-SMAD or Inhibitor SMAD is a subclass of SMADs that are involved in the modulation of transforming growth factor beta ligands . This class includes SMAD6 and SMAD7 . They compete with SMAD4 and consequently regulate the transcription of its gene products.
See also [ ]
External links [ ]
I-Smad+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
TGF beta family
Activin and inhibin
Nodal
Ligand of BMPR
TGF beta receptors (Activin , BMP , family )
TGFBR1: TGFBR2:
Activin type 2 receptors
AMHR2
BMPR2
TGFBR3:
Transducers /SMAD Ligand inhibitors Coreceptors Other
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS
AhR
AHRR
ARNT
CLOCK
HIF
NPAS
PER
SIM
Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP
AP-4
MAX
MITF
MNT
MLX
MLXIPL
MXI1
Myc
SREBP
USF1
(1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(3) Helix-turn-helix domains
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region (4.2) STAT (4.3) p53-like (4.4) MADS box (4.6) TATA-binding proteins (4.7) High-mobility group
BBX
HMGB
HMGN
HNF
SOX
SRY
SSRP1
TCF/LEF
TOX
(4.9) Grainyhead (4.10) Cold-shock domain (4.11) Runt
CBF
CBFA2T2
CBFA2T3
RUNX1
RUNX2
RUNX3
RUNX1T1
(0) Other transcription factors
see also transcription factor/coregulator deficiencies
Type I
ALK1 (ACVRL1 )
Agonists: Activin (A , B , AB )
Avotermin
BMP (10 )
GDF (2 (BMP9) )
TGFβ (1 , 2 , 3 )
Decoy receptors: Dalantercept
ALK2 (ACVR1A )
Agonists: Activin (A , B , AB )
AMH (MIS)
Avotermin
BMP (5 , 6 , 7 , 8A , 8B )
Eptotermin alfa
TGFβ (1 , 2 , 3 )
ALK3 (BMPR1A )
Agonists: AMH (MIS)
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B )
Dibotermin alfa
Eptotermin alfa
ALK4 (ACVR1B )
Agonists: Activin (A , B , AB )
GDF (1 , 3 , 11 (BMP11) )
Myostatin (GDF8)
Nodal
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
Kinase inhibitors:
SB-431542
ALK5 (TGFβR1 )
Agonists: Avotermin
GDF (10 (BMP3B) , 11 (BMP11) )
TGFβ (1 , 2 , 3 )
ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )
ALK7 (ACVR1C )
Agonists: GDF (1 , 3 , 11 (BMP11) )
Nodal
Antagonists: Lefty (1 , 2 )
Kinase inhibitors:
SB-431542
Type II
TGFβR2 BMPR2
Agonists: BMP (2 , 4 , 6 , 7 , 10 )
Dibotermin alfa
Eptotermin alfa
GDF (2 (BMP9) , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Antagonists: Inhibin (A , B )
ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )
Myostatin (GDF8)
Nodal
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
ACVR2B
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 6 , 7 )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Antagonists: Inhibin (A , B )
Lefty (1 , 2 )
AMHR2 (AMHR )
Type III
Unsorted
Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)
Categories :
Molecular and cellular biology stubs SMAD (protein) Transcription factors