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ELF2 Identifiers Aliases ELF2 , EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2External IDs MGI : 1916507 HomoloGene : 5006 GeneCards : ELF2 Gene location (Human ) Chr. Chromosome 4 (human) [1] Band 4q31.1 Start 139,028,112 bp [1] End 139,177,218 bp [1]
Gene location (Mouse ) Chr. Chromosome 3 (mouse)[2] Band 3|3 C Start 51,160,141 bp [2] End 51,248,084 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 4: 139.03 – 139.18 Mb Chr 3: 51.16 – 51.25 Mb PubMed search[3] [4] Wikidata
E74-like factor 2 (ELF2 ), formerly known as new Ets-related factor (NERF ), is an ETS family transcription factor .[5] In humans this protein is encoded by the ELF2 gene .[6]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000109381 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037174 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1" . Mol. Cell. Biol . 16 (9): 5091–106. doi :10.1128/MCB.16.9.5091 . PMC 231510 . PMID 8756667 .
^ "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)" .
Further reading [ ]
Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia" . Leukemia . 11 (1): 86–96. doi :10.1038/sj.leu.2400516 . PMID 9001422 .
Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias" . Mol. Cell. Biol . 19 (5): 3635–44. doi :10.1128/mcb.19.5.3635 . PMC 84165 . PMID 10207087 .
Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem . 85 (3): 505–15. doi :10.1002/jcb.10148 . PMID 11967990 . S2CID 36902890 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene" . J. Biol. Chem . 279 (19): 19512–22. doi :10.1074/jbc.M309074200 . PMID 14970218 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun . 356 (3): 536–41. doi :10.1016/j.bbrc.2007.02.160 . PMID 17368566 .
Categories :
Genes on human chromosome 4 Transcription factors Human chromosome 4 gene stubs