Gsx (gene family)

From Wikipedia, the free encyclopedia

The Gsx gene family are a group of genes found in many, but not all, animals. Gsx genes contain a homeobox DNA sequence and code for proteins that act as transcription factors. The human genome has two Gsx genes, called and (formerly GSH1 and GSH2), while the fruitfly Drosophila has a single Gsx gene called ind. Vertebrate Gsx genes are implicated in neural patterning.[1][2] In many animals, Gsx genes can be part of a ParaHox gene cluster.[3]

References[]

  1. ^ Cornell, RA; Ohlen, TV (2000). "VND/NKX, ind/GSH, and MSH/MSX: Conserved regulators of dorsoventral neural patterning?". Curr. Opin. Neurobiol. 10 (1): 63–71. doi:10.1016/S0959-4388(99)00049-5. PMID 10679430. S2CID 30021040.
  2. ^ Pei, Z; Wang, B; Chen, G; Nagao, M; Nakafuku, M; Campbell, K (Jan 25, 2011). "Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation". Proceedings of the National Academy of Sciences of the United States of America. 108 (4): 1675–80. Bibcode:2011PNAS..108.1675P. doi:10.1073/pnas.1008824108. PMC 3029701. PMID 21205889.
  3. ^ Brooke; et al. (1998). "The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster". Nature. 392 (6679): 920–922. Bibcode:1998Natur.392..920B. doi:10.1038/31933. PMID 9582071. S2CID 4398740.
Retrieved from ""