TEAD3

TEAD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EMW
Identifiers
Aliases	TEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDs	OMIM: 603170 MGI: 109241 HomoloGene: 81821 GeneCards: TEAD3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,497,079 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,569,791 bp
RNA expression pattern
	Top expressed in
	urinary bladder; ; esophagus; ; left ventricle; ; fundus; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; DNA binding; GO:0001948 protein binding; sequence-specific DNA binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; female pregnancy; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; hippo signaling; transcription, DNA-templated; asymmetric neuroblast division; positive regulation of transcription by RNA polymerase II; embryonic organ development;
	Sources:Amigo / QuickGO
Orthologs
	7005
	21678
	ENSG00000007866
	ENSMUSG00000002249
	Q99594
	P70210
	NM_003214; NM_001395214
	NM_001098226; NM_001204156; NM_011566
	NP_003205
	NP_001091696; NP_001191085; NP_035696
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.^[5]^[6]^[7]

Function[]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.^[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.^[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007866 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002249 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
^ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
^ ^a ^b "Entrez Gene: TEAD3 TEA domain family member 3".
^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.
^ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

External links[]

TEAD3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007866 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002249 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9889009-5] Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.

[pmid9148898-6] Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.

[entrez-7] "Entrez Gene: TEAD3 TEA domain family member 3".

[pmid2070413-8] Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.

[Mann_2007-9] Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

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TEAD3

Contents

Function[]

References[]

Further reading[]

External links[]