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LYL1 Identifiers Aliases LYL1 , bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family memberExternal IDs OMIM : 151440 MGI : 96891 HomoloGene : 4078 GeneCards : LYL1 Gene location (Human ) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 13,099,033 bp [1] End 13,103,161 bp [1]
Gene location (Mouse ) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.02 cM Start 85,428,078 bp [2] End 85,431,569 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 19: 13.1 – 13.1 Mb Chr 8: 85.43 – 85.43 Mb PubMed search[3] [4] Wikidata
Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene .[5] [6]
Interactions [ ]
LYL1 has been shown to interact with TCF3 [7] and NFKB1 .[8]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000104903 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034041 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell . 58 (1): 77–83. doi :10.1016/0092-8674(89)90404-2 . PMID 2752424 . S2CID 24737263 .
^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1" .
^ Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells" . Molecular and Cellular Biology . 16 (5): 2394–401. doi :10.1128/mcb.16.5.2394 . PMC 231228 . PMID 8628307 .
^ Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105" . Oncogene . 18 (4): 995–1005. doi :10.1038/sj.onc.1202374 . PMID 10023675 .
Further reading [ ]
Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia" . Proceedings of the National Academy of Sciences of the United States of America . 88 (24): 11416–20. Bibcode :1991PNAS...8811416X . doi :10.1073/pnas.88.24.11416 . PMC 53146 . PMID 1763056 .
Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML (June 1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene . 6 (6): 961–8. PMID 2067848 .
Saltman DL, Mellentin JD, Smith SD, Cleary ML (November 1990). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes, Chromosomes & Cancer . 2 (4): 259–65. doi :10.1002/gcc.2870020402 . PMID 2268576 . S2CID 103922 .
Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . The EMBO Journal . 13 (20): 4831–9. doi :10.1002/j.1460-2075.1994.tb06809.x . PMC 395422 . PMID 7957052 .
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (January 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers" . Genomics . 15 (1): 133–45. doi :10.1006/geno.1993.1021 . PMID 8432525 .
Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells" . Molecular and Cellular Biology . 16 (5): 2394–401. doi :10.1128/mcb.16.5.2394 . PMC 231228 . PMID 8628307 .
Mahajan MA, Park ST, Sun XH (June 1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene . 12 (11): 2343–50. PMID 8649774 .
Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105" . Oncogene . 18 (4): 995–1005. doi :10.1038/sj.onc.1202374 . PMID 10023675 .
Meng YS, Khoury H, Dick JE, Minden MD (November 2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia" . Leukemia . 19 (11): 1941–7. doi :10.1038/sj.leu.2403836 . PMID 16094422 .
External links [ ]
Categories :
Genes on human chromosome 19 Transcription factors Human chromosome 19 gene stubs