Liver receptor homolog-1

NR5A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RWV, 1YOK, 1YUC, 1ZDU, 2A66, 3PLZ, 3TX7, 4DOR, 4DOS, 4IS8, 4ONI, 4PLD, 4PLE
Identifiers
Aliases	NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2, nuclear receptor subfamily 5 group A member 2
External IDs	OMIM: 604453 MGI: 1346834 HomoloGene: 20827 GeneCards: NR5A2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	200,177,420 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	136,888,186 bp
RNA expression pattern
	Top expressed in
	pancreas; ; Body of pancreas; ; liver; ; colon; ; islet of Langerhans; ; Right lobe of liver; ; small intestine; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; zinc ion binding; GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; GO:0000975 transcription cis-regulatory region binding; metal ion binding; steroid hormone receptor activity; GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; GO:0001948 protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; double-stranded DNA binding; phospholipid binding; lipid binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; RNA polymerase II transcription regulator complex; nucleus;
Biological process	regulation of transcription, DNA-templated; epithelial cell differentiation; pancreas morphogenesis; bile acid metabolic process; transcription, DNA-templated; positive regulation of transcription, DNA-templated; intracellular receptor signaling pathway; regulation of cell population proliferation; tissue development; hormone-mediated signaling pathway; cholesterol homeostasis; positive regulation of viral genome replication; transcription initiation from RNA polymerase II promoter; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; homeostatic process; calcineurin-mediated signaling; cellular response to leukemia inhibitory factor; embryo development ending in birth or egg hatching;
	Sources:Amigo / QuickGO
Orthologs
	2494
	26424
	ENSG00000116833
	ENSMUSG00000026398
	O00482
	P45448
	NM_001276464; NM_003822; NM_205860
	NM_001159769; NM_030676
	NP_001263393; NP_003813; NP_995582
	NP_001153241; NP_109601
	Wikidata
View/Edit Human	View/Edit Mouse

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.^[5]^[6] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.^[7]^[8]^[9]

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.^[10]

Interactions[]

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.^[11]^[12]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116833 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026398 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bernier D, Thomassin H, Allard D, Guertin M, Hamel D, Blaquière M, Beauchemin M, LaRue H, Estable-Puig M, Bélanger L (Mar 1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology. 13 (3): 1619–33. doi:10.1128/mcb.13.3.1619. PMC 359474. PMID 7680097.
^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. S2CID 46813832.
^ Fayard E, Auwerx J, Schoonjans K (May 2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
^ Luo Y, Liang CP, Tall AR (Jul 2001). "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry. 276 (27): 24767–73. doi:10.1074/jbc.M100912200. PMID 11331284.
^ Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.
^ Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology. 25 (9): 3492–505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.
^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
^ Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

External links[]

NR5A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116833 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026398 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7680097-5] Bernier D, Thomassin H, Allard D, Guertin M, Hamel D, Blaquière M, Beauchemin M, LaRue H, Estable-Puig M, Bélanger L (Mar 1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology. 13 (3): 1619–33. doi:10.1128/mcb.13.3.1619. PMC 359474. PMID 7680097.

[pmid9858833-6] Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833. S2CID 46813832.

[pmid15130581-7] Fayard E, Auwerx J, Schoonjans K (May 2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.

[CETP-8] Luo Y, Liang CP, Tall AR (Jul 2001). "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry. 276 (27): 24767–73. doi:10.1074/jbc.M100912200. PMID 11331284.

[cholesterolhydroxylase-9] Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.

[10] Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology. 25 (9): 3492–505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.

[pmid12198243-11] Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.

[pmid11668176-12] Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.

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Liver receptor homolog-1

Contents

Interactions[]

References[]

Further reading[]

External links[]