Transient neonatal diabetes

Classification	D ICD-10: P70.2; OMIM: 601410 610374 610582; MeSH: C563322;
External resources	GeneReviews: Diabetes Mellitus, 6q24-Related Transient Neonatal;

Transient neonatal diabetes
Transient neonatal diabetes
	Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner
Specialty	Pediatrics

Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types[]

Type	OMIM	Gene	Locus	Description
TNDM1	601410	ZFP57, PLAGL1	6p22.1, 6q24.2
TNDM2	610374	ABCC8	11p15.1	Due to the mutations of the other subunit of the K_ATP channel, SUR1, which is encoded by the ABCC8 gene.^[2]
TNDM3	610582	KCNJ11	11p15.1

Cause[]

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).^{[citation needed]}

The form on chromosome 6 can involve imprinting.^[3]

^[4]

Diagnosis[]

Management[]

References[]

^ "OMIM Entry - # 610582 - DIABETES MELLITUS, TRANSIENT NEONATAL, 3". omim.org. Retrieved 12 September 2017.
^ de Wet H, Proks P, Lafond M, et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. doi:10.1038/embor.2008.71. PMC 2475326. PMID 18497752.
^ Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010.
^ "Other Forms (MODY, LADA, Neonatal)". www.DiabetesCare.net. DiabetesCare.net. Retrieved 20 November 2014.

External links[]

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[1] "OMIM Entry - # 610582 - DIABETES MELLITUS, TRANSIENT NEONATAL, 3". omim.org. Retrieved 12 September 2017.

[pmid18497752-2] Wet H, Proks P, Lafond M, et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. doi:10.1038/embor.2008.71. PMC 2475326. PMID 18497752.

[Scharfmann2007-3] Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010.

[Neonatal_Diabetes-4] "Other Forms (MODY, LADA, Neonatal)". www.DiabetesCare.net. DiabetesCare.net. Retrieved 20 November 2014.

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show v t Diabetes
Types	Type 1 Type 2 LADA Gestational diabetes Diabetes and pregnancy Prediabetes Impaired fasting glucose Impaired glucose tolerance Insulin resistance KPD MODY Neonatal Transient Permanent Type 3c (pancreatogenic) Type 3
Blood tests	Blood sugar level Glycated hemoglobin Glucose tolerance test Postprandial glucose test Fructosamine Glucose test C-peptide Noninvasive glucose monitor Insulin tolerance test
Management	Diet in diabetes Diabetes medication Insulin therapy intensive conventional pulsatile Cure Embryonic stem cells Artificial pancreas Other Gastric bypass surgery
Complications	Diabetic comas Hypoglycemia Ketoacidosis Hyperosmolar hyperglycemic state Diabetic foot ulcer Neuropathic arthropathy Organs in diabetes Blood vessels Muscle Kidney Nerves Retina Heart Diabetes-related skin disease Diabetic dermopathy Diabetic bulla Diabetic cheiroarthropathy Neuropathic ulcer Hyperglycemia Hypoglycemia
Other	Glossary of diabetes History of diabetes Notable people with type 1 diabetes

show v t Genetic disorder, membrane: ABC-transporter disorders
ABCA	ABCA1 (Tangier disease) ABCA3 (Surfactant metabolism dysfunction 3) ABCA4 (Stargardt disease 1, Retinitis pigmentosa 19) ABCA12 (Harlequin-type ichthyosis, Lamellar ichthyosis 2)
ABCB	ABCB4 (Progressive familial intrahepatic cholestasis 3) ABCB7 (ASAT) ABCB11 (Progressive familial intrahepatic cholestasis 2)
ABCC	ABCC2 (Dubin–Johnson syndrome) ABCC6 (Pseudoxanthoma elasticum) ABCC7 (Cystic fibrosis) ABCC8 (HHF1, TNDM2) ABCC9 (Dilated cardiomyopathy 1O)
ABCD	ABCD1 (Adrenoleukodystrophy, Adrenomyeloneuropathy)
ABCG	ABCG5 (Sitosterolemia) ABCG8 (Gallbladder disease 4, Sitosterolemia)
see also ABC transporters