Transmembrane protein 151b
TMEM151B | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | TMEM151B, C6orf137, TMEM193, bA444E17.5, transmembrane protein 151B | ||||||||||||||||||||||||
External IDs | MGI: 2685169 HomoloGene: 19365 GeneCards: TMEM151B | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 6: 44.27 – 44.31 Mb | Chr 17: 45.85 – 45.86 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.[5]
Nomenclature[]
The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.[6]
Gene[]
The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.[7] It is a complex locus that contains both TMEM151B and SPATS1.[8] TMEM151B has one paralog: TMEM151A.[9]
Transcript[]
The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.[7]
Protein[]
The protein has a length of 566 amino acids and contains two transmembrane domains.[6] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72.[11][6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.[12]
Expression[]
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.[14] NCBI geo profiles similarly show localization to the brain tissues.[15] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.[13]
Protein interactions[]
The TMEM151B protein interacts with one other protein according to BioGRID.[16]
- SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.[17]
Homology and Evolution[]
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.[9][18] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.[9][19]
Research[]
Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer.[20] It was also found to be up-regulated in post-menopausal breast cancer.[21][22] A SNP found within TMEM151B is associated with the development of lean muscle.[23]
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178233 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096847 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Transmembrane protein 151B".
- ^ a b c "transmembrane protein 151B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
- ^ a b "Homo sapiens transmembrane protein 151B (TMEM151B), mRNA - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
{{cite web}}
: CS1 maint: url-status (link) - ^ "AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2021-10-04.
- ^ a b c d "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "Protter - interactive protein feature visualization". wlab.ethz.ch. Retrieved 2022-01-13.
- ^ "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-01-13.
- ^ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ^ a b "ISH Data :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2022-01-13.
- ^ "TMEM151B transmembrane protein 151B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "GDS596 / 213678_at". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ^ "TMEM151B (RP11-444E17.5) Result Summary | BioGRID". thebiogrid.org. Retrieved 2022-01-13.
- ^ "SREBF2 Gene - GeneCards | SRBP2 Protein | SRBP2 Antibody". www.genecards.org. Retrieved 2022-01-13.
- ^ "Clustal Omega < Multiple Sequence Alignment < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ^ "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2022-01-13.
- ^ Liu J, Li H, Shen S, Sun L, Yuan Y, Xing C (2018). "Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer". Journal of Cancer. 9 (10): 1754–1764. doi:10.7150/jca.24569. PMID 29805701.
- ^ Carter JM, Nair AA, Davila JI, Heinzen EP, Hoskin TL, Winham SJ, et al. (2019-02-15). "Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer". Poster Session Abstracts. American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-p3-08-10.
- ^ Qian D, Zheng Q, Wu D, Ye B, Qian Y, Zhou T, et al. (2021-05-13). "Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer". Frontiers in Oncology. 11: 670138. doi:10.3389/fonc.2021.670138. PMID 34055638.
- ^ Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, et al. (November 2019). "Two functional variants at 6p21.1 were associated with lean mass". Skeletal Muscle. 9 (1): 28. doi:10.1186/s13395-019-0212-3. PMID 31757224.
Further reading[]
- Tsai JY, Namin-Gonzalez ML, Silver LM (December 1994). "False association of human ESTs". Nature Genetics. 8 (4): 321–322. doi:10.1038/ng1294-321. PMID 7894479. S2CID 6963700.
- Genes on human chromosome 6
- Human chromosome 6 gene stubs