The 1922 United States Senate election in Texas was held on November 7, 1922. Incumbent Democratic U.S. Senator Charles Culberson ran for re-election to a fifth term, but lost the Democratic primary. A runoff between former Governor Pa Ferguson and Railroads Commissioner Earle Bradford Mayfield.
In the runoff, Mayfield, a member of the Texas Railroad Commission defeated Ferguson for the Democratic nomination, then tantamount to election in Texas as a legacy of the American Civil War.[1] Mayfield had the support of the resurgent Ku Klux Klan, and anti-Klan activists in the Democratic Party including George Peddy were unable to have him stripped of the nomination.[1] Peddy agreed to run against Mayfield as the candidate of the "Independent Democrats", members of the party who opposed the Klan.[1] The Texas Republican Party also backed Peddy, but was unable to have him included on the general election ballot as their official nominee.[1]
Peddy ran a write-in campaign as the candidate of the Independent Democrats and Republicans.[1] In the general election, he ran a surprisingly strong race and held Mayfield to a smaller margin than was usual for Texas Democrats, but Mayfield defeated him 264,260 votes (66.9%) to 130,744 (33.1%).[1] Peddy challenged Mayfield's election, and the subsequent Senate investigation prevented Mayfield from taking his seat as scheduled on March 4, 1923.[1] Peddy's challenge was denied, and Mayfield assumed his seat on February 4, 1925.[2]