Acetylsalicylic acid/dipyridamole

Acetylsalicylic acid/dipyridamole
Combination of
Acetylsalicylic acid	Anticoagulant
Dipyridamole	Anticoagulant
Clinical data
Trade names	Aggrenox, Asasantin
AHFS/Drugs.com	UK Drug Information
Routes of; administration	Oral
ATC code	B01AC30 (WHO) ;
Identifiers
CAS Number	50-78-2 ; 58-32-2 ;
PubChem CID	137329;
ChemSpider	121018;
UNII	R16CO5Y76E; 64ALC7F90C ;
KEGG	D11615;

The combination drug acetylsalicylic acid/dipyridamole (trade names Aggrenox, Asasantin) is a drug combination of:^[1]

Acetylsalicylic acid (Aspirin) - An extremely common NSAID that has anticoagulant effects
Dipyridamole, a drug that inhibits platlet activation^[2] when given chronically and causes vasodilation when given at high doses over short time.

The combination acts as an extended release formulation and is primarily used for platelet inhibition in patients suffering, or at risk from, acute coronary events and stroke.^[3] Its use has been shown to be better than the use of either dipyridamole or aspirin alone.^[4]

References[]

^ FASS (the Swedish official drug catalog) > Asasantin Last update: 2009–08–17
^ "Dipyridamole" at Dorland's Medical Dictionary
^ Malinin AI, Eisert RM, Atar D, Barkagan Z, Serebruany VL (2002). "Aggrenox (Extended-Release Dipyridamole and Low-Dose Aspirin in Combination): Protecting Platelets from Excessive Activation in Patients with Vascular Events". Heart Drug. 2 (2): 93–104. doi:10.1159/000063427. S2CID 71396361.
^ Serebruany VL, Malinin AI, Sane DC, Jilma B, Takserman A, Atar D, Hennekens CH (September 2004). "Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial". European Journal of Pharmacology. 499 (3): 315–24. doi:10.1016/j.ejphar.2004.07.114. PMID 15381054.

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[1] FASS (the Swedish official drug catalog) > Asasantin Last update: 2009–08–17

[2] "Dipyridamole" at Dorland's Medical Dictionary

[3] Malinin AI, Eisert RM, Atar D, Barkagan Z, Serebruany VL (2002). "Aggrenox (Extended-Release Dipyridamole and Low-Dose Aspirin in Combination): Protecting Platelets from Excessive Activation in Patients with Vascular Events". Heart Drug. 2 (2): 93–104. doi:10.1159/000063427. S2CID 71396361.

[4] Serebruany VL, Malinin AI, Sane DC, Jilma B, Takserman A, Atar D, Hennekens CH (September 2004). "Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial". European Journal of Pharmacology. 499 (3): 315–24. doi:10.1016/j.ejphar.2004.07.114. PMID 15381054.

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