Otamixaban

Otamixaban
Clinical data
ATC code	none;
Identifiers
	show IUPAC name
CAS Number	193153-04-7 ;
PubChem CID	5496659;
ChemSpider	4593439 ;
UNII	S173RED00L;
ChEMBL	ChEMBL46618 ;
CompTox Dashboard (EPA)	DTXSID40172917 ;
Chemical and physical data
Formula	C25H26N4O4
Molar mass	446.507 g·mol−1
3D model (JSmol)	Interactive image;
	show SMILES
	show InChI
	(what is this?)

Otamixaban (INN) is an experimental injectable anticoagulant direct factor Xa inhibitor^[1] that was investigated for the treatment for acute coronary syndrome. In 2013, Sanofi announced that it had ended development of the drug candidate after poor performance in a Phase III clinical trial.^[2]^[3]

References[]

^ Guertin KR, Choi YM (2007). "The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development". Curr. Med. Chem. 14 (23): 2471–81. doi:10.2174/092986707782023659. PMID 17979700.
^ "AstraZeneca, Sanofi Cut Programs". Chemical & Engineering News. American Chemical Society. 91 (23): 17. June 10, 2013. Sanofi is ending development on two compounds, the anticancer compound iniparib and the anticoagulant otamixaban, both of which flunked Phase III studies.
^ "Sanofi's Investigational Iniparib, Otamixaban Fail To Meet Goals, Ends Programs". RTT news. Retrieved 11 April 2014.

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[pmid17979700-1] Guertin KR, Choi YM (2007). "The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development". Curr. Med. Chem. 14 (23): 2471–81. doi:10.2174/092986707782023659. PMID 17979700.

[2] "AstraZeneca, Sanofi Cut Programs". Chemical & Engineering News. American Chemical Society. 91 (23): 17. June 10, 2013. Sanofi is ending development on two compounds, the anticancer compound iniparib and the anticoagulant otamixaban, both of which flunked Phase III studies.

[3] "Sanofi's Investigational Iniparib, Otamixaban Fail To Meet Goals, Ends Programs". RTT news. Retrieved 11 April 2014.

[1]

[2]

[3]

Clinical data


ATC code	none
Identifiers
show IUPAC name Methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate
CAS Number	193153-04-7^N
PubChem CID	5496659
ChemSpider	4593439^Y
UNII	S173RED00L
ChEMBL	ChEMBL46618^Y
CompTox Dashboard (EPA)	DTXSID40172917
Chemical and physical data
Formula	C₂₅H₂₆N₄O₄
Molar mass	446.507 g·mol⁻¹
3D model (JSmol)	Interactive image
show SMILES O=C(OC)[C@H](Cc1cc(C(=[N@H])N)ccc1)[C@H](NC(=O)c3ccc(c2cc[n+]([O-])cc2)cc3)C
show InChI InChI=1S/C25H26N4O4/c1-16(22(25(31)33-2)15-17-4-3-5-21(14-17)23(26)27)28-24(30)20-8-6-18(7-9-20)19-10-12-29(32)13-11-19/h3-14,16,22H,15H2,1-2H3,(H3,26,27)(H,28,30)/t16-,22-/m1/s1^Y Key:PFGVNLZDWRZPJW-OPAMFIHVSA-N^Y
^NY (what is this?)