Amylocaine
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IUPAC name
benzoic acid [1-(dimethylaminomethyl)-1-methylpropyl] ester
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Identifiers | |
3D model (JSmol)
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ECHA InfoCard | 100.010.375 |
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CompTox Dashboard (EPA)
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Properties | |
C14H21NO2 | |
Molar mass | 235.32204 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
what is ?) | (|
Infobox references | |
Amylocaine was the first synthetic local anesthetic. It was synthesized and patented under the name Stovaine by Ernest Fourneau at the Pasteur Institute in 1903.[1] It was used mostly in spinal anesthesia.[2]
See also[]
- Dimethylaminopivalophenone, an opioid with a similar structure–activity relationship (SAR). It is an amine that is a sole methylene spacer shorter.
Notes and references[]
- ^ Fourneau, E. (1904). "Stovaïne, anesthésique local". Bulletin des sciences pharmacologiques. 10: 141-148.
- ^ Debue-Barazer, Christine (2007). "Les Implications scientifiques et industrielles du succès de la Stovaïne : Ernest Fourneau (1872-1949) et la chimie des médicaments en France" Archived 2013-10-05 at the Wayback Machine. Gesnerus 64 (1-2): 24-53.
External links[]
- Smith, Maurice I.; Hatcher, Robert A. (January 1917). "A Contribution to the Pharmacology of Stovaine". Journal of Pharmacology and Experimental Therapeutics. 9 (4): 231–240.
- Ball, Christine M.; Westhorpe, Rod N. (2004). "Local Anaesthesia after Cocaine". Anaesthesia and Intensive Care. 32 (2): 157. PMID 15957711.
Categories:
- Local anesthetics
- Benzoate esters
- Dimethylamino compounds
- Nervous system drug stubs