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Cinaciguat Routes of administration intravenous (?)ATC code
4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl) phenyl]methoxy}phenyl)ethyl]amino}methyl) benzoic acid
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII ChEBI CompTox Dashboard (EPA ) Formula C 36 H 39 N O 5 Molar mass 565.710 g·mol−1 3D model (JSmol )
c4ccccc4CCc3ccc(cc3)COc1ccccc1CCN(CCCCC(O)=O)Cc2ccc(C(=O)O)cc2
InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)
N Key:WPYWMXNXEZFMAK-UHFFFAOYSA-N
N
N Y (what is this?)
Cinaciguat (BAY 58-2667 ) is an experimental drug for the treatment of acute decompensated heart failure .
Mechanism of action [ ]
Cinaciguat activates the soluble guanylate cyclase (sGC) which is a receptor for nitric oxide . This increases biosynthesis of cyclic GMP , resulting in vasodilation .[1]
See also [ ]
Riociguat , another drug stimulating sGC, but with a different mechanism
PDE5 inhibitors act further downstream in the nitric oxide signalling pathway, reducing cyclic GMP degradation.
References [ ]
^ Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel 2009
Forms Targets
NO donors (prodrugs ) Enzyme (inhibitors )
Others
Indirect/downstream NO modulators: ACE inhibitors /AT-II receptor antagonists (e.g., captopril , losartan )
ETB receptor antagonists (e.g., bosentan )
L-Type calcium channel blockers (e.g., dihydropyridines : nifedipine )
Nebivolol (beta blocker )
PDE5 inhibitors (e.g., sildenafil )
non-selective PDE inhibitors (e.g., caffeine )
PDE9 inhibitors (e.g., paraxanthine )
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
Statins (e.g., simvastatin )
See also: Receptor/signaling modulators
Categories :
Drugs not assigned an ATC code Vasodilators Benzoic acids Phenol ethers Cardiovascular system drug stubs Hidden categories:
Articles with changed ChemSpider identifier Articles with changed InChI identifier Chemical pages without DrugBank identifier Articles without KEGG source Drugs with no legal status Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields All stub articles