Isopropyl nitrite

Isopropyl nitrite
Clinical data
Other names	Isopropyl alcohol nitrite; nitrous acid, isopropyl ester; 1-methylethyl nitrite; 2-propyl nitrite
ATC code	None;
Identifiers
	show IUPAC name
CAS Number	541-42-4 ;
PubChem CID	10929;
ChemSpider	10466 ;
UNII	2T3Y2PS0ZE;
CompTox Dashboard (EPA)	DTXSID3052191 ;
ECHA InfoCard	100.007.982
Chemical and physical data
Formula	C3H7NO2
Molar mass	89.09 g·mol−1
3D model (JSmol)	Interactive image;
Density	0.8684 g/cm3
Boiling point	40 °C (104 °F)
	show SMILES
	show InChI

The chemical compound isopropyl nitrite (or 2-propyl nitrite) is an alkyl nitrite made from isopropanol. It is a clear pale yellow oil that is insoluble in water.^[1]

Isopropyl nitrite in a glass bottle

Applications[]

Isopropyl nitrite is one of the compounds used as poppers, an inhalant drug that induces a brief euphoria. Isopropyl nitrite has largely replaced isobutyl nitrite in poppers.

Safety[]

For more information, see poppers.

Isopropyl nitrite has been associated with eye maculopathy, visual impairment with central scotomata, bilateral foveal yellow spots, and inner segment/outer segment (IS/OS) junction disruption,^[2] which may be reversible.^[3]

References[]

^ Handbook of Chemistry and Physics, CRC Press, 85th edition
^ Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–86. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.
^ Inserm. "Des pertes visuelles chez les consommateurs de poppers". www.inserm.fr (in French). Archived from the original on 2012-06-05. Retrieved 2017-01-23.

[1] Handbook of Chemistry and Physics, CRC Press, 85th edition

[2] Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–86. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.

[3] Inserm. "Des pertes visuelles chez les consommateurs de poppers". www.inserm.fr (in French). Archived from the original on 2012-06-05. Retrieved 2017-01-23.

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