Daf-4

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abnormal dauer formation protein 4
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-4
Entrez175781
HomoloGene124563
UniProtP50488
Other data
ChromosomeIII: 5.63 - 5.63 Mb

The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans,[1] with the ligands Daf-7 or .[2] When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the type I receptor, and activated the Sma-2/3/4.[3]

References[]

  1. ^ Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6284–8. Bibcode:2001PNAS...98.6284M. doi:10.1073/pnas.111409798. PMC 33460. PMID 11353865.
  2. ^ Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 790–4. doi:10.1073/pnas.93.2.790. PMC 40134. PMID 8570636.
  3. ^ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239.


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