RFX3

RFX3
Identifiers
Aliases	RFX3, regulatory factor X3
External IDs	OMIM: 601337 MGI: 106582 HomoloGene: 7917 GeneCards: RFX3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	3,526,004 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	28,011,166 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948 protein binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• transcription regulator complex; • nucleus; • extracellular region;
Biological process	• cell differentiation; • regulation of transcription, DNA-templated; • positive regulation of type B pancreatic cell development; • regulation of insulin secretion; • epithelial cilium movement involved in determination of left/right asymmetry; • cell maturation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • multicellular organism development; • type B pancreatic cell maturation; • determination of left/right symmetry; • negative regulation of transcription, DNA-templated; • cilium-dependent cell motility; • endocrine pancreas development; • positive regulation of transcription by RNA polymerase II; • type B pancreatic cell differentiation; • cilium assembly; • regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5991
	19726
	ENSG00000080298
	ENSMUSG00000040929
	P48380
	P48381
	NM_001282116; NM_001282117; NM_002919; NM_134428; NM_001377999
	NM_001166414; NM_011265; NM_001360357; NM_001360358
	NP_001269045; NP_001269046; NP_002910; NP_602304; NP_001364928
	NP_001159886; NP_035395; NP_001347286; NP_001347287
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.^[5]^[6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080298 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040929 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. doi:10.1128/mcb.14.2.1230. PMC 358479. PMID 8289803.
^ ^a ^b "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)".

Further reading[]

Emery P, Durand B, Mach B, Reith W (1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.
Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains". Mol. Cell. Biol. 19 (6): 3940–50. doi:10.1128/mcb.19.6.3940. PMC 104353. PMID 10330134.
Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.
Nakayama A, Murakami H, Maeyama N, et al. (2003). "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter". J. Biol. Chem. 278 (1): 233–40. doi:10.1074/jbc.M209574200. PMID 12411430.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578. S2CID 2408607.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080298 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040929 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8289803-5] Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. doi:10.1128/mcb.14.2.1230. PMC 358479. PMID 8289803.

[entrez-6] "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)".

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