Immunoglobulin V-set domain

Immunoglobulin V-set domain
Structure of phosphocholine binding immunoglobulin Fab McPC603.[1]
Identifiers
Symbol	V-set
Pfam	PF07686
InterPro	IPR013106
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2mcpH:1-121 1mcpH:1-121 1ohqB:20-116 1houH:20-116 1hezB:20-138 2fb4H:2-125 2ig2H:2-125 1mqkH:20-116 1ub6A:4-96 1ub5A:1-96 1i8kB:26-116 1i8iB:26-116 1igcH:17-135 1l7iH:20-139 2dlfH:1-114 1sm3H:2-114 2fbjH:1-117 7fabH:2-116 1ezvX:20-115 1kcsH:25-115 1kcvH:25-115 1j1pH:2-112 1ic5H:2-112 1j1xH:2-112 1c08B:2-112 1ic4H:2-112 1ic7H:2-112 1j1oH:2-112 1g7mB:20-115 1dvfB:20-115 1g7lB:20-115 1g7hB:20-115 1g7jB:20-115

V-set domains are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1).

Subfamilies[]

• InterPro: IPR003596
• InterPro: IPR013285

Human proteins containing this domain[]

; ACAN; ADAMTSL1; ; AMICA1; BCAM; BCAN; BGP; ; ; BTN1A1; ; BTN2A2; ; BTN3A1; ; BTN3A3; BTNL2; ; ; ; C10orf54; ; ; CADM1; ; CADM3; ; CD2; CD226; CD274; CD276; CD300A; CD300C; ; ; ; CD300LF; ; CD33; CD3G; CD7; CD79A; CD79B; CD80; CD83; CD86; CD8A; CD8B; ; CD96; CEACAM1; CEACAM16; CEACAM19; CEACAM21; CEACAM3; CEACAM4; CEACAM5; CEACAM6; CEACAM7; CEACAM8; CHL1; ; ; CSF1R; CTLA4; CXADR; ERMAP; ESAM; F11R; ; FCRL2; ; GLUDP5; GPA33; HAPLN1; HAPLN2; ; ; HAVCR1; HEPACAM; ; HSPG2; ICOSLG; IGHA1; IGHA2; IGHD; IGHG1; IGHG3; IGHM; ; ; ; IGKC; ; ; IGL@; ; ; ; ; ; ; ; ; IGSF2; IGSF3; ; IGSF8; ; IL18R1; ; ; JAM2; JAM3; KDR; KIRREL; KIRREL2; KIRREL3; LAG3; ; ; MAG; ; MOG; MPZ; MPZL1; ; MXRA8; MYBPC3; NCA; NCR2; NCR3; NPHS1; OBSL1; OPCML; P0; PDCD1; PIGR; PILRA; PILRB; ; PSG1; PSG10; ; ; PSG2; PSG3; PSG4; PSG5; PSG6; ; ; PSG9; PTGFRN; ; PVR; PVRL1; PVRL2; PVRL3; ; SCN2B; SCN3B; SCN4B; ; SIGLEC1; SIGLEC10; ; SIGLEC12; ; ; ; SIGLEC7; SIGLEC8; SIGLEC9; SIRPA; SIRPB1; ; SIRPG; ; SLAMF6; SLAMF7; ; TCRA; ; TIMD4; TRA@; ; TRBC1; ; ; ; ; ; TREM1; TREM2; TREML1; ; ; ; ; ; TRGV9; VCAM1; VCAN; VPREB1; VPREB3; VSIG1; VSIG2; VSIG4; ; ; ; ; VTCN1;

References[]

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