CD226

CD226
Identifiers
Aliases	CD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule
External IDs	OMIM: 605397 MGI: 3039602 HomoloGene: 4787 GeneCards: CD226
Gene location (Human)
Chr.	Chromosome 18 (human)
End	69,961,803 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	89,272,229 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • GO:0001948 protein binding; • protein kinase binding; • integrin binding; • cell adhesion molecule binding;
Cellular component	• integral component of plasma membrane; • membrane raft; • integral component of membrane; • membrane; • cell surface; • external side of plasma membrane; • plasma membrane;
Biological process	• positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; • cell adhesion; • regulation of immune response; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • homophilic cell adhesion via plasma membrane adhesion molecules; • positive regulation of Fc receptor mediated stimulatory signaling pathway; • cell recognition; • cytokine production; • positive regulation of immunoglobulin mediated immune response; • signal transduction; • positive regulation of natural killer cell mediated cytotoxicity; • positive regulation of mast cell activation; • positive regulation of interferon-gamma production; • positive regulation of natural killer cell cytokine production; • positive regulation of T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10666
	225825
	ENSG00000150637
	ENSMUSG00000034028
	Q15762
	Q8K4F0
	NM_001303618; NM_001303619; NM_006566
	NM_001039148; NM_001039149; NM_178687
	NP_001290547; NP_001290548; NP_006557
	NP_001034238; NP_848802
	Wikidata
View/Edit Human	View/Edit Mouse

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')^[5] or DNAM-1 ( Accessory Molecule-1)^[5] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.^[6]

Structure and function[]

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.^[7]

CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,^[7]^[8] and cross-linking CD226 with antibodies causes cellular activation.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150637 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034028 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–66. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
^ ^a ^b "Entrez Gene: CD226 CD226 molecule".
^ ^a ^b Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". The Journal of Experimental Medicine. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". International Immunology. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

Further reading[]

Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH (June 1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes". Immunity. 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. hdl:2241/102273. PMID 8673704.
Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A (November 1999). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule". Immunity. 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. hdl:2241/102003. PMID 10591186.
Kojima H, Kanada H, Shimizu S, Kasama E, Shibuya K, Nakauchi H, Nagasawa T, Shibuya A (September 2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells". The Journal of Biological Chemistry. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.
Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, Miyamoto A, Onodera M, Sumida T, Nakauchi H, Miyoshi H, Shibuya A (December 2003). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation". The Journal of Experimental Medicine. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMC 2194159. PMID 14676297.
Reymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, Farnarier C, Cantoni C, Bottino C, Moretta A, Dubreuil P, Lopez M (May 2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions". The Journal of Experimental Medicine. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMC 2211807. PMID 15136589.
Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L (March 2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.
Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A (February 2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis". Molecular Immunology. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.
Tao D, Shangwu L, Qun W, Yan L, Wei J, Junyan L, Feili G, Boquan J, Jinquan T (February 2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus". Journal of Immunology. 174 (3): 1281–90. doi:10.4049/jimmunol.174.3.1281. PMID 15661884.
Ma D, Sun Y, Lin D, Wang H, Dai B, Zhang X, Ouyang W, Jian J, Jia W, Xu X, Jin B (March 2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization". European Journal of Haematology. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793. S2CID 23453162.
Storojeva I, Boulay JL, Ballabeni P, Buess M, Terracciano L, Laffer U, Mild G, Herrmann R, Rochlitz C (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer". Oncology. 68 (2–3): 246–55. doi:10.1159/000086781. PMID 16015041. S2CID 21262033.
Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (September 2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". The Journal of Biological Chemistry. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.
Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ (September 2006). "Identification and characterization of the CD226 gene promoter". The Journal of Biological Chemistry. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.
Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients". Viral Immunology. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.
El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP (September 2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Research. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.

External links[]

CD226+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CD226 genome location and CD226 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150637 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034028 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Fuchs-2006-5] Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–66. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.

[entrez-6] "Entrez Gene: CD226 CD226 molecule".

[pmid12913096-7] Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". The Journal of Experimental Medicine. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.

[pmid15039383-8] Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". International Immunology. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

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v t Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD226

Structure and function[]

See also[]

References[]

Further reading[]

External links[]