ICAM3

ICAM3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1T0P
Identifiers
Aliases	ICAM3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3
External IDs	OMIM: 146631 HomoloGene: 88479 GeneCards: ICAM3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,339,661 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• integrin binding; • signaling receptor binding; • GO:0001948 protein binding;
Cellular component	• integral component of membrane; • plasma membrane; • integral component of plasma membrane; • extracellular exosome; • membrane;
Biological process	• cell adhesion; • extracellular matrix organization; • stimulatory C-type lectin receptor signaling pathway; • regulation of immune response; • phagocytosis; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3385
	n/a
	ENSG00000076662
	n/a
	P32942
	n/a
NM_002162; NM_001320605; NM_001320606; NM_001320608; NM_001395374;
	NM_001395375; NM_001395376
	n/a
	NP_001307534; NP_001307535; NP_001307537; NP_002153
	n/a
	Wikidata
View/Edit Human

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene.

Function[]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.^[3] It functions not only as an adhesion molecule, but also as a potent signalling molecule.^[4]

Interactions[]

ICAM3 has been shown to interact with EZR^[5]^[6] and Moesin.^[6]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076662 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ de Fougerolles AR, Springer TA (Jan 1992). "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes". The Journal of Experimental Medicine. 175 (1): 185–90. doi:10.1084/jem.175.1.185. PMC 2119096. PMID 1730916.
^ "Entrez Gene: ICAM3 intercellular adhesion molecule 3".
^ Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". The Journal of Biological Chemistry. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328.
^ ^a ^b Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". The Journal of Biological Chemistry. 277 (12): 10400–9. doi:10.1074/jbc.M110694200. PMID 11784723.
^ Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" (PDF). The Journal of Cell Biology. 138 (6): 1409–23. doi:10.1083/jcb.138.6.1409. PMC 2132557. PMID 9298994.

Further reading[]

Simmons DL (1995). "The role of ICAM expression in immunity and disease". Cancer Surveys. 24: 141–55. PMID 7553659.
Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions". Immunologic Research. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365.
Fawcett J, Holness CL, Needham LA, Turley H, Gatter KC, Mason DY, Simmons DL (Dec 1992). "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes". Nature. 360 (6403): 481–4. Bibcode:1992Natur.360..481F. doi:10.1038/360481a0. PMID 1448173. S2CID 4310468.
Vazeux R, Hoffman PA, Tomita JK, Dickinson ES, Jasman RL, St John T, Gallatin WM (Dec 1992). "Cloning and characterization of a new intercellular adhesion molecule ICAM-R". Nature. 360 (6403): 485–8. Bibcode:1992Natur.360..485V. doi:10.1038/360485a0. PMID 1448174. S2CID 4315548.
Pino-Otín MR, Juan M, de la Fuente MA, Viñas O, Martínez-Cáceres E, Fernández MD, Miralles A, Vilella R, Yagüe J, Vives J (Jul 1995). "CD50 (intercellular adhesion molecule-3) is expressed at higher levels on memory than on naive human T cells but induces a similar calcium mobilization on both subsets". Tissue Antigens. 46 (1): 32–44. doi:10.1111/j.1399-0039.1995.tb02473.x. PMID 7482494.
Marazuela M, Postigo AA, Acevedo A, Díaz-González F, Sanchez-Madrid F, de Landázuri MO (Oct 1994). "Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands". European Journal of Immunology. 24 (10): 2483–90. doi:10.1002/eji.1830241034. PMID 7523142. S2CID 25833828.
Holness CL, Bates PA, Little AJ, Buckley CD, McDowall A, Bossy D, Hogg N, Simmons DL (Jan 1995). "Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1". The Journal of Biological Chemistry. 270 (2): 877–84. doi:10.1074/jbc.270.2.877. PMID 7822326.
Martin S, Rieckmann P, Melchers I, Wagner R, Bertrams J, Voskuyl AE, Roep BO, Zielasek J, Heidenthal E, Weichselbraun I (Feb 1995). "Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1". Journal of Immunology. 154 (4): 1951–5. PMID 7836774.
Bossy D, Mattei MG, Simmons DL (Oct 1994). "The human intercellular adhesion molecule 3 (ICAM3) gene is located in the 19p13.2-p13.3 region, close to the ICAM1 gene". Genomics. 23 (3): 712–3. doi:10.1006/geno.1994.1565. PMID 7851905.
Skubitz KM, Ahmed K, Campbell KD, Skubitz AP (Mar 1995). "CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils". Journal of Immunology. 154 (6): 2888–95. PMID 7876557.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Juan M, Vilella R, Mila J, Yagüe J, Miralles A, Campbell KS, Friedrich RJ, Cambier J, Vives J, De Fougerolles AR (Jul 1993). "CDw50 and ICAM-3: two names for the same molecule". European Journal of Immunology. 23 (7): 1508–12. doi:10.1002/eji.1830230717. PMID 8325327. S2CID 23774801.
de Fougerolles AR, Klickstein LB, Springer TA (Apr 1993). "Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1". The Journal of Experimental Medicine. 177 (4): 1187–92. doi:10.1084/jem.177.4.1187. PMC 2190956. PMID 8459213.
Hosaka S, Shah MR, Pope RM, Koch AE (Mar 1996). "Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids". Clinical Immunology and Immunopathology. 78 (3): 276–82. doi:10.1006/clin.1996.0039. PMID 8605703.
Van der Vieren M, Le Trong H, Wood CL, Moore PF, St John T, Staunton DE, Gallatin WM (Dec 1995). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3". Immunity. 3 (6): 683–90. doi:10.1016/1074-7613(95)90058-6. PMID 8777714.
Hayflick JS, Stine J, Fox R, Hoekstra D, Gallatin WM (Aug 1997). "Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues". The Journal of Biological Chemistry. 272 (35): 22207–14. doi:10.1074/jbc.272.35.22207. PMID 9268366.
Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" (PDF). The Journal of Cell Biology. 138 (6): 1409–23. doi:10.1083/jcb.138.6.1409. PMC 2132557. PMID 9298994.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bernstein CN, Sargent M, Gallatin WM (Feb 1998). "Beta2 integrin/ICAM expression in Crohn's disease". Clinical Immunology and Immunopathology. 86 (2): 147–60. doi:10.1006/clin.1997.4462. PMID 9473377.

External links[]

ICAM3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076662 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Fougerolles AR, Springer TA (Jan 1992). "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes". The Journal of Experimental Medicine. 175 (1): 185–90. doi:10.1084/jem.175.1.185. PMC 2119096. PMID 1730916.

[entrez-4] "Entrez Gene: ICAM3 intercellular adhesion molecule 3".

[pmid9705328-5] Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (Aug 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". The Journal of Biological Chemistry. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328.

[pmid11784723-6] Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F (Mar 2002). "A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting". The Journal of Biological Chemistry. 277 (12): 10400–9. doi:10.1074/jbc.M110694200. PMID 11784723.

[pmid9298994-7] Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (Sep 1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" (PDF). The Journal of Cell Biology. 138 (6): 1409–23. doi:10.1083/jcb.138.6.1409. PMC 2132557. PMID 9298994.

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v t Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350