The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimericcytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.[5]
Interactions[]
IL3RA has been shown to interact with Interleukin 3.[6][7]
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Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID7651724.
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Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM (1998). "Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils". J. Immunol. 160 (9): 4427–32. PMID9574547.
Res PC, Couwenberg F, Vyth-Dreese FA, Spits H (1999). "Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus". Blood. 94 (8): 2647–57. doi:10.1182/blood.V94.8.2647.420k06_2647_2657. PMID10515868.
Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A (2002). "Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases". J. Hepatol. 36 (6): 734–41. doi:10.1016/S0168-8278(02)00062-4. PMID12044522.
External links[]
IL3RA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.