NCR1

NCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OLL, 1P6F
Identifiers
Aliases	NCR1, CD335, LY94, NK-p46, NKP46, natural cytotoxicity triggering receptor 1
External IDs	OMIM: 604530 MGI: 1336212 HomoloGene: 3551 GeneCards: NCR1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,916,140 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,348,163 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; bone marrow; ; lung; ; adrenal gland; ; Right lobe of liver; ; thymus; ; liver; ; lymph node;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; SWI/SNF complex; membrane;
Biological process	cellular defense response; natural killer cell activation; signal transduction; regulation of immune response; regulation of natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	9437
	17086
ENSG00000273535; ENSG00000277629; ENSG00000273916; ENSG00000275156; ENSG00000277824;
	ENSG00000277334; ENSG00000278362; ENSG00000275637; ENSG00000274053; ENSG00000275521; ENSG00000275822; ENSG00000277442; ENSG00000189430; ENSG00000284113; ENSG00000273506; ENSG00000276450; ENSG00000278025; ENSG00000288651
	ENSMUSG00000062524
	O76036
	Q8C567
	NM_001145457; NM_001145458; NM_001242356; NM_001242357; NM_004829
	NM_010746; NM_001368364
	NP_001138929; NP_001138930; NP_001229285; NP_001229286; NP_004820
	NP_034876; NP_001355293
	Wikidata
View/Edit Human	View/Edit Mouse

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.^[5]^[6] NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.^[7]

References[]

^ ^a ^b ^c ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 GRCh38: Ensembl release 89: ENSG00000273535, ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062524 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med. 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMC 3207313. PMID 9730896.
^ "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".
^ "NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI".

Further reading[]

Biassoni R, Cantoni C, Marras D, et al. (2004). "Human natural killer cell receptors: insights into their molecular function and structure". J. Cell. Mol. Med. 7 (4): 376–87. doi:10.1111/j.1582-4934.2003.tb00240.x. PMC 6740120. PMID 14754506.
Sivori S, Vitale M, Morelli L, et al. (1997). "p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation". J. Exp. Med. 186 (7): 1129–36. doi:10.1084/jem.186.7.1129. PMC 2211712. PMID 9314561.
Vitale M, Bottino C, Sivori S, et al. (1998). "NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis". J. Exp. Med. 187 (12): 2065–72. doi:10.1084/jem.187.12.2065. PMC 2212362. PMID 9625766.
Cantoni C, Bottino C, Vitale M, et al. (1999). "NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily". J. Exp. Med. 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
Vankayalapati R, Wizel B, Weis SE, et al. (2002). "The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium". J. Immunol. 168 (7): 3451–7. doi:10.4049/jimmunol.168.7.3451. PMID 11907104.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048. S2CID 10724743.
Ponassi M, Cantoni C, Biassoni R, et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. doi:10.1016/j.bbrc.2003.08.007. PMID 12951052.
Foster CE, Colonna M, Sun PD (2003). "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors". J. Biol. Chem. 278 (46): 46081–6. doi:10.1074/jbc.M308491200. PMID 12960161.
Arnon TI, Achdout H, Lieberman N, et al. (2004). "The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46". Blood. 103 (2): 664–72. doi:10.1182/blood-2003-05-1716. PMID 14504081.
Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045. S2CID 40345630.
Carbone E, Neri P, Mesuraca M, et al. (2005). "HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells". Blood. 105 (1): 251–8. doi:10.1182/blood-2004-04-1422. PMID 15328155.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005). "Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)". Clin. Exp. Immunol. 139 (2): 287–96. doi:10.1111/j.1365-2249.2004.02686.x. PMC 1809301. PMID 15654827.
Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
Zilka A, Landau G, Hershkovitz O, et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry. 44 (44): 14477–85. doi:10.1021/bi051241s. PMID 16262248.
Hermann E, Alonso-Vega C, Berthe A, et al. (2006). "Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells". Pediatr. Res. 60 (1): 38–43. doi:10.1203/01.pdr.0000220335.05588.ea. PMID 16690951.

External links[]

NCR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: O76036 (Natural cytotoxicity triggering receptor 1) at the PDBe-KB.

[refGRCh38Ensembl-1] ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 GRCh38: Ensembl release 89: ENSG00000273535, ENSG00000277629, ENSG00000273916, ENSG00000275156, ENSG00000277824, ENSG00000277334, ENSG00000278362, ENSG00000275637, ENSG00000274053, ENSG00000275521, ENSG00000275822, ENSG00000277442, ENSG00000189430, ENSG00000284113, ENSG00000273506, ENSG00000276450, ENSG00000278025, ENSG00000288651 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062524 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9730896-5] Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med. 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMC 3207313. PMID 9730896.

[entrez-6] "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".

[7] "NCR1 natural cytotoxicity triggering receptor 1 [Homo sapiens (human)] - Gene - NCBI".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350