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IGSF8 Identifiers Aliases IGSF8 , CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8External IDs OMIM : 606644 MGI : 2154090 HomoloGene : 14163 GeneCards : IGSF8 Gene location (Human ) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 160,091,340 bp [1] End 160,098,943 bp [1]
Gene location (Mouse ) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.59 cM Start 172,089,208 bp [2] End 172,147,408 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 160.09 – 160.1 Mb Chr 1: 172.09 – 172.15 Mb PubMed search[3] [4] Wikidata
Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene .[5] [6] [7] IGSF8 has also been designated as CD316 (cluster of differentiation 316).
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000162729 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038034 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily" . J Biol Chem . 276 (44): 40545–54. doi :10.1074/jbc.M107338200 . PMID 11504738 .
^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins" . J Immunol . 167 (9): 5115–21. doi :10.4049/jimmunol.167.9.5115 . PMID 11673522 .
^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8" .
Further reading [ ]
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells" . Biochem. J . 373 (Pt 2): 409–21. doi :10.1042/BJ20030343 . PMC 1223506 . PMID 12708969 .
Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res . 63 (10): 2665–74. PMID 12750295 .
Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol . 148 (4): 654–64. doi :10.1046/j.1365-2133.2003.05244.x . PMID 12752121 . S2CID 21635573 .
Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5" . J. Cell Biol . 163 (5): 1167–77. doi :10.1083/jcb.200309113 . PMC 2173626 . PMID 14662754 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions" . Blood . 103 (8): 3013–9. doi :10.1182/blood-2003-07-2201 . PMID 15070678 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization" . J. Biol. Chem . 281 (18): 12976–85. doi :10.1074/jbc.M510617200 . PMID 16537545 .
Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins" . J. Biol. Chem . 281 (28): 19665–75. doi :10.1074/jbc.M602116200 . PMID 16690612 .
Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells" . Mol. Cell. Biol . 27 (21): 7718–26. doi :10.1128/MCB.00180-07 . PMC 2169036 . PMID 17785435 .
External links [ ]
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Categories :
Genes on human chromosome 1 Clusters of differentiation Membrane protein stubs