CCR9

CCR9
Identifiers
Aliases	CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28, C-C motif chemokine receptor 9
External IDs	OMIM: 604738 MGI: 1341902 HomoloGene: 22546 GeneCards: CCR9
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,903,174 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,784,330 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• C-C chemokine receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • chemokine receptor activity; • chemokine binding; • C-C chemokine binding;
Cellular component	• cell surface; • integral component of membrane; • integral component of plasma membrane; • membrane; • plasma membrane; • intracellular anatomical structure; • external side of plasma membrane;
Biological process	• positive regulation of cytosolic calcium ion concentration; • chemotaxis; • chemokine-mediated signaling pathway; • cellular defense response; • G protein-coupled receptor signaling pathway; • immune response; • signal transduction; • CD8-positive, gamma-delta intraepithelial T cell differentiation; • calcium-mediated signaling; • cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	10803
	12769
	ENSG00000173585
	ENSMUSG00000029530
	P51686
	Q9WUT7
	NM_001256369; NM_006641; NM_031200; NM_001386447; NM_001386448
	NM_001166625; NM_009913
	NP_001243298; NP_006632; NP_112477
	NP_001160097; NP_034043
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.^[5]^[6]

CCR9 has also recently been designated CDw199 (cluster of differentiation w199).

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173585 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029530 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G (Jun 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". J Immunol. 162 (10): 5671–5. PMID 10229797.
^ ^a ^b "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".

Further reading[]

Youn BS, Kim CH, Smith FO, Broxmeyer HE (1999). "TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor". Blood. 94 (7): 2533–6. doi:10.1182/blood.V94.7.2533.419k37_2533_2536. PMID 10498628.
Zabel BA, Agace WW, Campbell JJ, et al. (1999). "Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis". J. Exp. Med. 190 (9): 1241–56. doi:10.1084/jem.190.9.1241. PMC 2195678. PMID 10544196.
Wurbel MA, Philippe JM, Nguyen C, et al. (2000). "The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9". Eur. J. Immunol. 30 (1): 262–71. doi:10.1002/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0. PMID 10602049.
Yu CR, Peden KW, Zaitseva MB, et al. (2000). "CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand". J. Immunol. 164 (3): 1293–305. doi:10.4049/jimmunol.164.3.1293. PMID 10640743.
Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689. S2CID 1178132.
Kunkel EJ, Campbell JJ, Haraldsen G, et al. (2000). "Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity". J. Exp. Med. 192 (5): 761–8. doi:10.1084/jem.192.5.761. PMC 2193265. PMID 10974041.
Papadakis KA, Prehn J, Nelson V, et al. (2000). "The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system". J. Immunol. 165 (9): 5069–76. doi:10.4049/jimmunol.165.9.5069. PMID 11046037.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Papadakis KA, Landers C, Prehn J, et al. (2003). "CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile". J. Immunol. 171 (1): 159–65. doi:10.4049/jimmunol.171.1.159. PMID 12816994.
Qiuping Z, Qun L, Chunsong H, et al. (2003). "Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia". Cancer Res. 63 (19): 6469–77. PMID 14559839.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Singh S, Singh UP, Stiles JK, et al. (2005). "Expression and functional role of CCR9 in prostate cancer cell migration and invasion". Clin. Cancer Res. 10 (24): 8743–50. doi:10.1158/1078-0432.CCR-04-0266. PMID 15623660.
Babu S, Blauvelt CP, Kumaraswami V, Nutman TB (2005). "Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesis". J. Infect. Dis. 191 (6): 1018–26. doi:10.1086/427658. PMID 15717282.
Sen Y, Yongyi B, Yuling H, et al. (2005). "V alpha 24-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement". J. Immunol. 175 (8): 4914–26. doi:10.4049/jimmunol.175.8.4914. PMID 16210593.
Nagakubo D, Jin Z, Hieshima K, et al. (2007). "Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax". Int. J. Cancer. 120 (7): 1591–7. doi:10.1002/ijc.22483. PMID 17205512. S2CID 23891689.
Olaussen RW, Karlsson MR, Lundin KE, et al. (2007). "Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation". Gastroenterology. 132 (7): 2371–82. doi:10.1053/j.gastro.2007.04.023. PMID 17570212.

External links[]

Human CCR9 genome location and CCR9 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR9". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173585 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029530 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10229797-5] Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G (Jun 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". J Immunol. 162 (10): 5671–5. PMID 10229797.

[entrez-6] "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".

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v t Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350