American biochemist
Karl August Folkers (September 1, 1906 – December 7, 1997) was an American biochemist who made major contributions to the isolation and identification of bioactive natural products .[1] [2]
Career [ ]
His career was mainly spent at Merck . He played a prominent role in the isolation of vitamin B12 , which is one of the most structural complex of the vitamins. As a Merck Pharmaceuticals research team, Folkers, Fern P. Rathe , and Edward Anthony Kaczka were the first to isolate the antibiotic cathomycin in 1955.[3] His team also isolated the antibiotic cycloserine .[4] In 1958 his Merck team determined the structure of coenzyme Q10 .[5]
In recognition for his scientific contributions, he received the Perkin Medal in 1960,[6] the William H. Nichols Medal in 1967,[7] the Priestley Medal in 1986, and the National Medal of Science in 1990.
References [ ]
^ Shive, William (2002). "Karl August Folkers, September 1, 1906 – December 9, 1997". Biographical Memoirs of the National Academy of Sciences . 81 : 100–14. PMID 12661556 .
^ Olson, R E (September 1, 2001). "Karl August Folkers (1906–1997)" . Journal of Nutrition . 131 (9): 2227–30. doi :10.1093/jn/131.9.2227 . PMID 11533258 .
^ Acc. 90-105 - Science Service, Records, 1920s-1970s, Smithsonian Institution Archives. Accessed 29 July 2013. http://siarchives.si.edu/collections/siris_arc_297416
^ Kuehl, Frederick A., Jr.; Wolf, Frank J.; Trenner, Nelson R.; Peck, Robert L.; Buhs, Rudolf P.; Putter, Irvin; Ormond, Robert; Lyons, John E.; Chaiet, Louis; Howe, Eugene; Hunnewell, Berl D.; Downing, Geo.; Newstead, E.; Folkers, Karl "D-4-Amino-3-isoxazolidinone, a new antibiotic" Journal of the American Chemical Society 1955, vol. 77, pp. 2344-5. doi :10.1021/ja01613a105 . Stammer, Charles H.; Wilson, Andrew N.; Holly, Frederick W.; Folkers, Karl "Synthesis of D-4-amino-3-isoxazolidinone" Journal of the American Chemical Society 1955, volume 77, 2346-7. doi :10.1021/ja01613a107
^ "History of CoQ10" .
^ "SCI Perkin Medal" . Science History Institute . Retrieved 24 March 2018 .
^ "NY-ACS Nichols Medalists" . www.newyorkacs.org .
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