Michele De Palma
Michele De Palma | |
---|---|
![]() Michele De Palma in 2011 | |
Born | 1973 (age 47–48) |
Academic background | |
Alma mater | University of Turin |
Academic advisors | Luigi Naldini |
Academic work | |
Discipline | Oncology |
Sub-discipline | Tumor immunology, Angiogenesis |
Institutions | École Polytechnique Fédérale de Lausanne (EPFL) |
Main interests | Tumor microenvironment, Exosomes, microRNAs, Cancer immunotherapy |
Website | https://www.epfl.ch/labs/depalma-lab/ |
Michele 'Miki' De Palma (born 1973, Italy) is an Italian biologist and a Professor at EPFL (École Polytechnique Fédérale de Lausanne). He is known for his work on the role of macrophages in cancer progression and the discovery of Tie2-expressing angiogenic monocytes.[1]
Career[]
De Palma obtained a master's degree in biology from the University of Turin in 1999 after defending his thesis on the cytostatic effects of type-I interferons on cancer cells. He then obtained a PhD in 2004 in the laboratory of Luigi Naldini, where he studied the effet of bone marrow-derived cells on tumor angiogenesis, and performed post-doctoral work at the Telethon Institute for Gene Therapy in Milan, further dissecting the role of macrophages and their potential use as a target for gene therapy in the treatment of cancer.[2]
De Palma was appointed group leader at the San Raffaele Scientific Institute in 2008. In 2012, he was named tenure-track assistant Professor at EPFL, where he was promoted to associate Professor in 2018.[3]
Research[]
De Palma heads the Angiogenesis and Tumor Microenvironment group at EPFL. His research focuses on the influence of the tumor microenvironment on cancer progression.[4] De Palma and colleagues use genetic models of cancer as well as genetically-engineered cells to decipher the complex interactions occurring between tumor cells, blood vessels, immune cells and exosomes in the tumor microenvironment.
De Palma is known for having discovered a subpopulation of Tie2-positive monocytes endowed with angiogenic capabilities, and which elicit tumor progression.[5] He later showed that inhibition of the Tie2-ligand Angiopoietin 2 induces tumor regression and inhibits metastasis by preventing angiogenesis.[6] He also identified expression of Angiopoietin 2 as an adaptive resistance mechanism upon anti-angiogenic treatment by VEGF inhibitors in a mouse model of pancreatic cancer.[7]
The laboratory of De Palma explores novel therapeutic strategies to overcome resistance to cancer immunotherapies. De Palma and colleagues notably showed that dual inhibition of Tie2 and VEGF-A promotes anti-tumor immunity and potentiates treatment by immune checkpoint inhibitors.[8][9] They also identified microRNAs as potential targets to reprogram tumor-associated macrophages and to promote their anti-tumoral immune functions.[10][11]
De Palma and colleagues also explore the role of extracellular vesicles in cancer progression and resistance to therapy. In 2019, they showed that chemotherapy stimulates the release of tumor-derivered pro-metastatic exosomes.[12][13][14] De Palma's group also developed a new generation of cancer vaccine based on dendritic cells engineered with a chimeric receptor called EVIR, designed to internalize tumor-derived exosomes and associated cancer antigens, thus stimulating anti-tumor immunity.[15]
De Palma has also published multiple studies on the taxonomy of scarabaeidae, including the description of several new species.[16][17]
Distinctions[]
In 2013, De Palma was awarded with the Leenaards Scientific Prize for his research on anti-angiogenic therapies and cancer immunotherapy.[18] He also received the 2017 Robert Wenner Prize awarded by the Swiss Cancer League.[19][20]
De Palma received a starting grant in 2009 and a consolidator grant in 2016 from the European Research Council.[21]
De Palma serves on the scientific advisory and editorial board of several peer-reviewed scientific journals, such as Science Translational Medicine,[22] Cell Reports,[23] BBA Reviews on Cancer[24] and Cancer Immunology Research.[25]
External links[]
- Michele de Palma's lab at EPFL.
- Michele De Palma publications indexed by Google Scholar
- Michele de Palma's profile on Scopus.
- Publications by Michele De Palma at ResearchGate
References[]
- ^ "Michele De Palma". people.epfl.ch. Retrieved 2020-09-10.
- ^ "Michele De Palma | VIB Conferences". www.vibconferences.be. Retrieved 2020-09-10.
- ^ "15 new professors appointed at the two Federal Institutes of Technology". www.seco.admin.ch. Retrieved 2020-09-10.
- ^ "Research Activities". www.epfl.ch. Retrieved 2020-09-10.
- ^ De Palma, Michele; Venneri, Mary Anna; Galli, Rossella; Sergi, Lucia Sergi; Politi, Letterio S.; Sampaolesi, Maurilio; Naldini, Luigi (2005-09-01). "Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors". Cancer Cell. 8 (3): 211–226. doi:10.1016/j.ccr.2005.08.002. ISSN 1535-6108. PMID 16169466.
- ^ Mazzieri, Roberta; Pucci, Ferdinando; Moi, Davide; Zonari, Erika; Ranghetti, Anna; Berti, Alvise; Politi, Letterio S.; Gentner, Bernhard; Brown, Jeffrey L.; Naldini, Luigi; De Palma, Michele (2011-04-12). "Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells". Cancer Cell. 19 (4): 512–526. doi:10.1016/j.ccr.2011.02.005. ISSN 1535-6108. PMID 21481792.
- ^ Rigamonti, Nicolò; Kadioglu, Ece; Keklikoglou, Ioanna; Wyser Rmili, Céline; Leow, Ching Ching; De Palma, Michele (2014-08-07). "Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade". Cell Reports. 8 (3): 696–706. doi:10.1016/j.celrep.2014.06.059. ISSN 2211-1247. PMID 25088418.
- ^ Schmittnaegel, Martina; Rigamonti, Nicolò; Kadioglu, Ece; Cassará, Antonino; Rmili, Céline Wyser; Kiialainen, Anna; Kienast, Yvonne; Mueller, Hans-Joachim; Ooi, Chia-Huey; Laoui, Damya; Palma, Michele De (2017-04-12). "Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade". Science Translational Medicine. 9 (385): eaak9670. doi:10.1126/scitranslmed.aak9670. ISSN 1946-6234. PMID 28404865. S2CID 8114974.
- ^ "Targeting blood vessels to improve cancer immunotherapy". ScienceDaily. Retrieved 2020-09-15.
- ^ Squadrito, Mario Leonardo; Pucci, Ferdinando; Magri, Laura; Moi, Davide; Gilfillan, Gregor D.; Ranghetti, Anna; Casazza, Andrea; Mazzone, Massimiliano; Lyle, Robert; Naldini, Luigi; De Palma, Michele (2012-02-23). "miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages". Cell Reports. 1 (2): 141–154. doi:10.1016/j.celrep.2011.12.005. ISSN 2211-1247. PMID 22832163.
- ^ Baer, Caroline; Squadrito, Mario Leonardo; Laoui, Damya; Thompson, Danielle; Hansen, Sarah K.; Kiialainen, Anna; Hoves, Sabine; Ries, Carola H.; Ooi, Chia-Huey; De Palma, Michele (July 2016). "Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity". Nature Cell Biology. 18 (7): 790–802. doi:10.1038/ncb3371. ISSN 1476-4679. PMID 27295554. S2CID 20788521.
- ^ Keklikoglou, Ioanna; Cianciaruso, Chiara; Güç, Esra; Squadrito, Mario Leonardo; Spring, Laura M.; Tazzyman, Simon; Lambein, Lore; Poissonnier, Amanda; Ferraro, Gino B.; Baer, Caroline; Cassará, Antonino (February 2019). "Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models". Nature Cell Biology. 21 (2): 190–202. doi:10.1038/s41556-018-0256-3. ISSN 1476-4679. PMC 6525097. PMID 30598531.
- ^ "Exosomes Linked to Cancer Spread from Chemoresistant Tumors in Mice". The Scientist Magazine®. Retrieved 2020-09-15.
- ^ "Tumors backfire on chemotherapy". EurekAlert!. Retrieved 2020-09-15.
- ^ Squadrito, Mario Leonardo; Cianciaruso, Chiara; Hansen, Sarah K.; De Palma, Michele (March 2018). "EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens". Nature Methods. 15 (3): 183–186. doi:10.1038/nmeth.4579. ISSN 1548-7105. PMC 5833950. PMID 29355847.
- ^ De Palma, Michele; Takano, Hitoshi; Léonard, Philippe; Bouyer, Thierry (2020). "Barcoding analysis and taxonomic revision of Goliathus Lamarck, 1802 (Scarabaeidae, Cetoniinae)" (PDF). Entemologia Africana. 25 (1): 11–32.
- ^ "Data scaraebaeoidea Bibliography". Retrieved 16 September 2020.
- ^ "Cibler l'angiogenèse et les réseaux immunosuppresseurs pour améliorer le traitement des cancers du sein et de l'ovaire". Fondation Leenaards - Favoriser la dynamique créatrice (in French). Retrieved 2020-09-15.
- ^ "Lauréats du Prix Robert Wenner depuis 1983" (PDF) (in French).
- ^ Papageorgiou, Nik. "Michele De Palma wins 2017 Swiss Cancer League prize". epfl.ch. Retrieved 15 September 2020.
- ^ "ERC FUNDED PROJECTS". ERC: European Research Council. Retrieved 2020-09-15.
- ^ "Editorial staff and scientific advisory boards | Science Translational Medicine". stm.sciencemag.org. Retrieved 2020-09-15.
- ^ "Cell Press: Cell Reports". www.cell.com. Retrieved 2020-09-15.
- ^ "Editorial board - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | ScienceDirect.com by Elsevier". www.sciencedirect.com. Retrieved 2020-09-15.
- ^ "Editorial Board | Cancer Immunology Research". cancerimmunolres.aacrjournals.org. Retrieved 2020-09-15.
- École Polytechnique Fédérale de Lausanne faculty
- 1973 births
- Living people
- Italian academics
- University of Turin alumni
- Italian biologists