Valentín Fuster

From Wikipedia, the free encyclopedia
In this Spanish name, the first or paternal surname is Fuster and the second or maternal family name is Carulla.
The Most Excellent

Valentín Fuster Carulla
Valentín Fuster (cropped).jpg
Born
Valentín Fuster Carulla

(1943-01-20) 20 January 1943 (age 78)
Barcelona, Spain
NationalitySpanish, American[1][2][3][4]
OccupationCardiologist
Parent(s)Joaquín Fuster, Father
RelativesMarquess of Carulla, grandmother
Joaquín Fuster, brother

Valentín Fuster Carulla, 1st Marquess of Fuster (born January 20, 1943) is a Spanish cardiologist.[5][2][3][4]

He is Editor-in-Chief of the Journal of the American College of Cardiology (JACC),[6] past President of the American Heart Association,[7] past President of the World Heart Federation,[7] Editor-in-Chief, Journal of the American College of Cardiology [8] and has been a member of the US National Academy of Medicine[7] and Member of the European Horizon 2020 Scientific Panel of Health.[9] In 2016 he co-chaired, with Jendayi Frazer, the Advisory Committee on The Role of the United States on Global Health.[10]

Fuster serves as Director of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, and Director of the Zena and Michael A. Wiener Cardiovascular Institute, the Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, and the Richard Gorlin, MD/Heart Research Foundation Professor at Icahn School of Medicine at Mount Sinai.[11]

He serves in Madrid as the General Director of the National Centre for Cardiovascular Research (CNIC)[12] and also chairs an international project, the SHE Foundation (Science for Health and Education).[13] In 2014, King Juan Carlos I of Spain granted him the title of Marquis for his "outstanding and unceasing research efforts and his educational outreach work".[14]

Life and career[]

Fuster was born in Barcelona, Spain. He is the son of a psychiatrist and his brother is a neuroscientist.[15] In Spain he competed in tennis at a national level.[16] Pedro Farreras Valentí, the author of the widely used Spanish textbook Farreras-Rozman Internal Medicine,[17] encouraged Fuster to study cardiology.[18]

Fuster graduated first in his class with an MD from University of Barcelona1967.[19] He completed an internship at the Hospital Clinic in Barcelona, then attended University of Edinburgh Medical School for a PhD on the role of platelets in myocardial infarction.[20]

Fuster served as a Research Fellow in Cardiology at the Royal Infirmary of Edinburgh from 1968 to 1971[20] After completing his PhD in 1971 from the University of Edinburgh Medical School.,[21] Fuster spent several years at the Mayo Clinic, first as a resident and later as Professor of Medicine and Consultant in Cardiology.[21][20] In 1981, he became head of cardiology at Mount Sinai School of Medicine. From 1991 to 1994, he was Mallinckrodt Professor of Medicine at Harvard Medical School and Chief of Cardiology at the Massachusetts General Hospital.[21] He returned to Mount Sinai in 1994 as Director of the Zena and Michael A. Wiener Cardiovascular Institute and in 2006 named the Director of Mount Sinai Heart.[22]

Fuster serves as physician-in-chief and Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health. He is also the Richard Gorlin, MD/Heart Research Foundation Professor at Icahn School of Medicine at Mount Sinai.[11] Fuster was the President of Science,[23] and is now the General Director of the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid, (Spain).[24]

Fuster was elected editor-in-chief at the Journal of the American College of Cardiology in 2014.[25] Former positions include President of the American Heart Association,[26] past president of the World Heart Federation,[27] member of the Institute of Medicine of the National Academy of Sciences[28] where he serves as Chair of the Committee on Preventing the Global Epidemic of Cardiovascular Disease,[29] former member of the National Heart, Lung, and Blood Institute Advisory Council,[30] and former Chairman of the Fellowship Training Directors Program of the American College of Cardiology. He has thirty-four university Honorary Doctorates.[11][24] According to Google Scholar, his peer-reviewed publications, as of 2020, have been cited 319,356. His h-index is 209 and i10-index is 1,206.[31]

He was the inspiration for a character on the Spanish version of Sesame Street named "Valentin Ruster" that educated children in healthier lifestyles through exercise and healthy diet.[32]

Honors and awards[]

Scientific investigator[]

Contributions in translational medicine[]

  • The original understanding of a major role played by platelets in atherothrombotic disease, based on long-term experiments in pigs with a deficiency of von Willebrand factor, severe platelet dysfunction, and resistance to atherothrombosis[43][44]
  • The first demonstration of the role played by platelets in CABG occlusion and prevention by aspirin, findings based on platelet imaging in dogs and on our subsequent definitive trial in humans (first trial of aspirin on CAD)[45][46]
  • The first demonstration in humans that coronary plaque rupture occurs in plaques that paradoxically are small and angiographically silent, an angiographic finding that explains the unpredictability of events and led to new diagnostic MRI technology on identification and characterization of arterial plaques at autopsy [47][48][49][50]
  • The first demonstration that a critical substrate of thrombosis following plaque rupture is a lipid-rich plaque (vulnerable plaque) with a high density of macrophages undergoing apoptotic death with a release of tissue factor, findings which are based on a sequence of experimental and clinical studies, in part based on MRI and PET technology[51]
  • The first identification and characterization by new MRI technology (black-blood) of the vulnerable/high-risk plaques and reversibility by statins, findings based on a sequence of animal and human studies that led to the recent interest in cardiovascular MR imaging [52]
  • The first demonstration in vivo of an important role of HDL in reversing lipid and macrophange-rich plaques, a finding based on the infusion of HDL in cholesterol-fed rabbits (and recently supported by others in CAD patients) and in cross-transplantation of the atherosclerotic aorta from transgenic mice with low HDL into mice with high HDL[53][54]
  • The first demonstration of rapamycin as a powerful inhibitor of post-injury smooth muscle cell migration/proliferation/extra-cellular matric development, which are findings first based on a series of in vitro studies, then documented in pigs and recently confirmed by others in humans by the prevention of restenosis with drug-eluted stents.[55]
  • The first demonstration of the great potency of antithrombins in the prevention of thrombosis in experimental animals, which has also been demonstrated recently in humans by his colleagues in the RE-LY trial on atrial fibrillation with the prevention of arterial embolism in those given oral antithrombins[56]
  • Based on MRI technology, demonstration in animals and humans of the development of neovascularization in the adventitia and media with the purpose to remove oxidized LDL-C from the intima, specifically when LDL-C in blood decreases with statins[57][58]
  • The documentation by MRI technology in animals and of histopathology in humans, that neovasculature, by leaking red blood cells into the interstitium induces an inflammatory reaction that predisposes to the rupture of the internal elastic lamina and eventually to plaque rupture and thrombotic occlusion[58][59]

Books[]

Author[]

  • Hurst's the Heart Manual of Cardiology, 12th Edition by Robert O'Rourke, Richard Walsh and Valentin Fuster (Jan 27, 2009) ISBN 0-071-84324-8
  • The Heart Manual: My Scientific Advice for Eating Better, Feeling Better, and Living a Stress-Free Life Now by Valentin Fuster (Feb 2, 2010) ISBN 0-061-76591-0
  • The AHA Guidelines and Scientific Statements Handbook (Fuster, The AHA Guidelines And Scientific Statements Handbook) by Valentin Fuster (Jan 6, 2009)
  • Atherothrombosis and Coronary Artery Disease by Valentin Fuster, Eric J. Topol and Elizabeth G. Nabel (Nov 8, 2004)
  • Platelets in Thrombotic and Non-Thrombotic Disorders Pathophysiology, Pharmacology and Therapeutics Paolo Gresele, Clive P. Page, Valentin Fuster, Jos Vermylen Hardback (ISBN 9780521802611)
  • Thrombosis in Cardiovascular Disorders [Hardcover] Valentin Fuster (Author), Marc Verstraete (Author)
  • Update on Coronary Risk Factors, An Issue of Medical Clinics of North America [Hardcover] Valentin Fuster, MD, PhD (Author), and Jagat Narula
  • La Ciencia de la Salud: Mis consejos para una vida sana (Spanish Edition) by Valentin Fuster (Dec 26, 2007) ISBN 8-408-06620-X
  • Cardiovascular Thrombosis: Thrombocardiology and Thromboneurology [Hardcover] Marc Verstraete (Author), Valentin Fuster (Author), Fuster (Author)
  • La ciencia y la vida/ Science And Life (Spanish Edition) [Paperback] Valentin Fuster (Author), Jose Luis Sampedro (Author)
  • [Cardiovascular Magnetic Resonance: Established and Emerging Applications [Hardcover] Albert Lardo (Author), Zahi Fayad (Author), Nicolas Chronos (Author), Valentin Fuster (Author)
  • La pequeña ciencia de la salud [Perfect Paperback] Valentin Fuster (Author)
  • Monstruos supersanos [Perfect Paperback] Valentin Fuster (Author)
  • La cocina de la salud by Valentín Fuster / Ferran Adrià / Josep Corbella (2010)
  • La vostra salute mi sta a cuore [Perfect Paperback] Josep Corbella Valentín Fuster
  • La buona cucina della salute. La ricetta di un famoso chef e di un grande medico per vivere bene senza rinunce [Perfect Paperback] Valentin Fuster, Josep Corbella Ferran Adrià (Author)
  • El Círculo de la motivación [Planeta de Libros] Valentín Fuster con la colaboracíon de Emma Reverter ISBN 1-697-11266-8

Editor[]

  • The Vulnerable Atherosclerotic Plaque: Understanding, Identification and Modification [Hardcover] Valentin Fuster (Editor)
  • Evolving Challenges in Promoting Cardiovascular Health by Annals of the New York Academy of Sciences Editorial Staff, Valentin Fuster (Editor) May 2012, Paperback
  • Assessing and Modifying the Vulnerable Atherosclerotic Plaque by Valentin Fuster (Editor) with William Insull Jr., MD June 2002, Hardcover
  • Oxidative Stress and Cardiac Failure by Marrick Kukin (Editor), Valentin Fuster (Editor) October 2002, Hardcover
  • Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook [Hardcover] Paolo Gresele (Editor), Valentin Fuster (Editor), Jose A. Lopez (Editor), Clive P. Page (Editor), Jos Vermylen (Editor)
  • Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health] [Paperback] Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries (Author), Institute of Medicine (Author), Valentin Fuster (Editor), Bridget B. Kelly (Editor)
  • Syndromes of Atherosclerosis: Correlations of Clinical Imaging and Pathology [Hardcover] Valentin Fuster (Editor)
  • Efficacy of Myocardial Infarction Therapy [Hardcover] Valentin Fuster (Editor)
  • Editor-in-chief of Nature Reviews Cardiology, April 2009

References[]

  1. ^ "Dr Valentí Fuster". Retrieved 20 August 2015.
  2. ^ Jump up to: a b "Valentin Fuster". Retrieved 20 August 2015.
  3. ^ Jump up to: a b "Spain Honors Valentin Fuster, MD, PhD, of The Mount Sinai Medical Center". Mount Sinai. 25 Jul 2013. Retrieved 20 August 2015.
  4. ^ Jump up to: a b Mellado, Ana (25 Jul 2013). "Valentín Fuster. el guardian de la salud de las estrellas". Diario ABC. Retrieved 20 August 2015.
  5. ^ "Dr Valentin Fuster". Retrieved 20 August 2015.
  6. ^ "About | Journal of the American College of Cardiology". www.jacc.org. Retrieved 2020-11-12.
  7. ^ Jump up to: a b c "American Heart Association To Honor Valentin Fuster, MD, PhD at Long Island Heart and Stroke Ball – American Heart Association – Eastern States". easternstates.heart.org. Retrieved 2020-11-12.
  8. ^ http://www.journals.elsevier.com/jacc-journal-of-the-american-college-of-cardiology/editorial-board/
  9. ^ "Register of Commission expert groups and other similar entities". ec.europa.eu. Retrieved 2021-08-25.
  10. ^ "Prominent cardiologist Valentin Fuster to lead global health committee". www.cardiovascularbusiness.com. Retrieved 2021-08-25.
  11. ^ Jump up to: a b c "Doctor Profile", Mount Sinai Hospital retrieved May 13, 2015
  12. ^ https://www.cnic.es/en/personal/person.php?p=m_inv&per=415
  13. ^ Fúster, Valentin (2010), "[Science, health and education: a priority and a model]", Archivos de Cardiologia de Mexico, 80 (4): 261–271, PMID 21169091
  14. ^ "BOLETÍN OFICIAL DEL ESTADO" (PDF). BOE (in Spanish). Retrieved August 25, 2021.
  15. ^ "'El origen de la libertad está en la corteza cerebral'". ELMUNDO (in Spanish). 2014-06-30. Retrieved 2020-10-28.
  16. ^ O'Rourke, Robert (2006). "ValentÍn Fuster". Clinical Cardiology. 29 (12): 556–557. doi:10.1002/clc.20038. PMC 6654763. PMID 17190182.
  17. ^ Pedro Farreras (1876-1955). Ciencia Veterinaria, nº 473, publicado el 10 de junio de 1955 Consultado el 30 de noviembre de 2016.
  18. ^ "Las ocho claves para vivir mejor". BBVA Aprendemos juntos (in Spanish). Retrieved 2020-10-28.
  19. ^ Fuster, V. (2000-07-01). "Valentin Fuster, MD, PhD: a conversation with the editor1". American Journal of Cardiology. 86 (2): 182–197. doi:10.1016/S0002-9149(00)00940-1. ISSN 0002-9149. PMID 10913480.
  20. ^ Jump up to: a b c "VALENTIN FUSTER, M.D., PH.D. Curriculum Vitae" (PDF). Mount Sinai. Retrieved 17 August 2013.
  21. ^ Jump up to: a b c O'Rourke, R. A. (2006). "Valentin Fuster". Clinical Cardiology. 29 (12): 556–557. doi:10.1002/clc.20038. PMC 6654763. PMID 17190182.
  22. ^ "Spotlight: Dr Valentin Fuster, MD, PhD, FESC" (PDF). Journal of the American Heart Association. 115 (13). 2007. doi:10.1161/circ.115.13.f55.
  23. ^ "About the CNIC". Spanish National Center for Cardiovascular Health. Retrieved November 12, 2020.
  24. ^ Jump up to: a b "Valentin Fuster Carulla", CNIC retrieved March 12, 2013
  25. ^ http://www.theheart.org/article/1569917.do
  26. ^ Fuster, Valentin (2006). "Passing the Torch". Journal of the American Heart Association. 100 (2): 106. doi:10.1161/01.CIR.100.2.106. PMID 10402436.
  27. ^ http://www.world-heart-federation.org/about-us/board/biographies/biography-past-president/
  28. ^ Wood, Shelley (2000). "Valentin Fuster Elected to Institute of Medicine". HeartWire.
  29. ^ "Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries", CNIC retrieved March 12, 2013
  30. ^ "Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report", NHLBI Archived 2008-10-01 at the Wayback Machine retrieved March 12, 2013
  31. ^ "Valentin Fuster". scholar.google.es. Retrieved 2021-05-20.
  32. ^ http://www.sesameworkshop.org/press-room/barrio-sesamo-monstruos-supersanos/
  33. ^ "Valentin Fuster Honored with Grand Prix Award", TheHeart retrieved March 21, 2013
  34. ^ "Previous Years Distinguished Scientists", American Heart Association retrieved March 21, 2013
  35. ^ "Valentin Fuster - Technical & Scientific Research 1996", Fundacion Principe de Asturias retrieved March 21, 2013
  36. ^ "James B. Herrick Award for Outstanding Achievement in Clinical Cardiology", American Heart Association Archived 2013-02-04 at the Wayback Machine retrieved March 21, 2013
  37. ^ "IASC Presents Valentin Fuster with the Distinguished Researcher Award", Newswise retrieved March 21, 2013
  38. ^ "Valentin Fuster Biography", CNIC retrieved March 13, 2013
  39. ^ "Valentin Fuster". Institut de France. Grands Prix des Fondations. 2015-04-21. Retrieved 2017-12-12.
  40. ^ "New York City scientist wins American Heart Association award for major additions to knowledge of artery disease process, treatments", American Heart Association retrieved March 12, 2013
  41. ^ Royal Decree 967/2017, 3rd november retrieved November 18, 2017
  42. ^ "Announcement of the Prince Mahidol Award 2020 Laureates". thailand.prd.go.th. Retrieved 2020-11-12.
  43. ^ Fuster, Valentin; Bowie, E. J. Walter; Lewis, Jon C.; Fass, David N.; Owen, Charles A.; Brown, Arnold L. (1978). "Resistance to Arteriosclerosis in Pigs with von Willebrand's Disease". Journal of Clinical Investigation. 61 (3): 722–30. doi:10.1172/JCI108985. PMC 372586. PMID 305924.
  44. ^ Fuster, V; Fass, DN; Kaye, MP; Josa, M; Zinsmeister, AR; Bowie, EJ (Nov 1982). "Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study". Circ Res. 51 (5): 587–93. doi:10.1161/01.res.51.5.587. PMID 6814782.
  45. ^ Fuster, V; Dewanjee, MK; Kaye, MP; Josa, M; Metke, MP; Chesebro, JH (Dec 1979). "Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors". Circulation. 60 (7): 1508–12. doi:10.1161/01.cir.60.7.1508. PMID 315282.
  46. ^ Chesebro, James H.; Fuster, Valentin; Elveback, Lila R.; Clements, Ian P.; Smith, Hugh C.; Holmes, David R.; Bardsley, William T.; Pluth, James R.; Wallace, Robert B.; Puga, Francisco J.; Orszulak, Thomas A.; Piehler, Jeffrey M.; Danielson, Gordon K.; Schaff, Hartzell V.; Frye, Robert L. (1984). "Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations". New England Journal of Medicine. 310 (4): 209–14. doi:10.1056/NEJM198401263100401. PMID 6361561.
  47. ^ Ambrose, JA; Tannenbaum, MA; Alexopoulos, D; Hjemdahl-Monsen, CE; Leavy, J; Weiss, M; Borrico, S; Gorlin, R; Fuster, V (Jul 1988). "Angiographic progression of coronary artery disease and the development of myocardial infarction". J Am Coll Cardiol. 12 (1): 56–62. doi:10.1016/0735-1097(88)90356-7. PMID 3379219.
  48. ^ Epstein, Franklin H.; Fuster, Valentin; Badimon, Lina; Badimon, Juan J.; Chesebro, James H. (1992). "The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes". New England Journal of Medicine. 326 (4): 242–50. doi:10.1056/NEJM199201233260406. PMID 1727977.
  49. ^ Epstein, Franklin H.; Fuster, Valentin; Badimon, Lina; Badimon, Juan J.; Chesebro, James H. (1992). "The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes". New England Journal of Medicine. 326 (5): 310–8. doi:10.1056/NEJM199201303260506. PMID 1728735.
  50. ^ Fuster, V; Fallon, JT; Nemerson, Y (November 1996). "Coronary thrombosis". Lancet. 348 Suppl 1: s7–10. doi:10.1016/s0140-6736(96)98003-4. PMID 8918520. S2CID 33481366.
  51. ^ Fuster, V (Oct 1994). "Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology". Circulation. 90 (4): 2126–46. doi:10.1161/01.cir.90.4.2126. PMID 7718033.
  52. ^ Fayad, ZA; Fuster, V (Aug 2001). "Clinical imaging of the high-risk or vulnerable atherosclerotic plaque". Circ Res. 89 (4): 305–16. doi:10.1161/hh1601.095596. PMID 11509446.
  53. ^ Badimon, J J; Badimon, L; Fuster, V (1990). "Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit". Journal of Clinical Investigation. 85 (4): 1234–41. doi:10.1172/JCI114558. PMC 296557. PMID 2318976.
  54. ^ Ibanez, Borja; Vilahur, Gemma; Cimmino, Giovanni; Speidl, Walter S.; Pinero, Antonio; Choi, Brian G.; Zafar, M. Urooj; Santos-Gallego, Carlos G.; Krause, Brian; Badimon, Lina; Fuster, Valentin; Badimon, Juan J. (2008). "Rapid Change in Plaque Size, Composition, and Molecular Footprint After Recombinant Apolipoprotein A-IMilano (ETC-216) Administration". Journal of the American College of Cardiology. 51 (11): 1104–9. doi:10.1016/j.jacc.2007.09.071. PMID 18342230.
  55. ^ Poon, Michael; Badimon, Juan Jose; Fuster, Valentin (2002). "Viewpoint Overcoming restenosis with sirolimus: From alphabet soup to clinical reality". The Lancet. 359 (9306): 619–622. doi:10.1016/S0140-6736(02)07751-6. PMID 11867133. S2CID 41817456.
  56. ^ Heras, M; Chesebro, JH; Webster, MW; Mruk, JS; Grill, DE; Penny, WJ; Bowie, EJ; Badimon, L; Fuster, V (Oct 1990). "Hirudin, heparin, and placebo during deep arterial injury in the pig. The in vivo role of thrombin in platelet-mediated thrombosis". Circulation. 82 (4): 1476–84. CiteSeerX 10.1.1.1016.6665. doi:10.1161/01.cir.82.4.1476. PMID 2401076.
  57. ^ Corti, R; Fuster, V; Fayad, ZA; Worthley, SG; Helft, G; Smith, D; Weinberger, J; Wentzel, J; Mizsei, G; Mercuri, M; Badimon, JJ (Dec 2002). "Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging". Circulation. 106 (23): 2884–7. doi:10.1161/01.cir.0000041255.88750.f0. PMID 12460866.
  58. ^ Jump up to: a b Moreno, P. R.; Purushothaman, K. R.; Sirol, M; Levy, A. P.; Fuster, V (2006). "Neovascularization in Human Atherosclerosis". Circulation. 113 (18): 2245–52. doi:10.1161/CIRCULATIONAHA.105.578955. PMID 16684874.
  59. ^ Moreno, PR; Sanz, J; Fuster, V (Jun 2009). "Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport". J Am Coll Cardiol. 53 (25): 2315–23. doi:10.1016/j.jacc.2009.02.057. PMID 19539140.

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