Uğur Şahin

From Wikipedia, the free encyclopedia

Uğur Şahin
Ugur Sahin v1.jpg
Şahin in 2019
Born (1965-09-29) 29 September 1965 (age 55)
İskenderun, Turkey
Alma mater
OccupationOncologist, immunologist
Years active1991–present
Known for
OfficeCEO BioNTech SE
Term2008–present
Spouse(s)
(m. 2002)
Awards
  • Merit Award of the American Society of Clinical Oncology
  • Georges Köhler Prize
  • German Cancer Award
  • Order of Merit of the Federal Republic of Germany
  • Mustafa Prize (2019)
WebsiteProfile at BioNTech

Uğur Şahin ([uˈuɾ ʃaː.hin]; born 29 September 1965) is a German oncologist, immunologist and CEO of BioNTech, which helped develop one of the major vaccines against COVID-19.[1][2] His main fields of research are cancer research and immunology.[3]

Şahin's family, originally from Turkey, moved to Germany when he was four years old. He grew up in Cologne and studied medicine at the University of Cologne, completing a doctoral thesis there in cancer immunotherapy. He initially remained in academia, in patient care as an oncohematology physician and conducting research at university hospitals in Saarland and Zurich and eventually founding a research group at the University of Mainz in 2000. He became a professor of experimental oncology in 2006. In 2001, while maintaining his position at the university Mainz, he began to engage in entrepreneurial activities, co-founding two pharmaceutical companies in 2001 and 2008 with his partner and spouse Özlem Türeci. The second of these companies, BioNTech, developed one of the major vaccines used to fight the COVID-19 pandemic together with Pfizer Inc in 2020. As a result of the company's increase in value, Şahin and Türeci became the first Germans with Turkish roots among Germany's top 100 wealthiest people list.[4]

Life[]

Şahin was born on 29 September 1965 in İskenderun into a Turkish-Alevi family.[5] He moved with his mother to Germany at the age of four to join with his father, who worked in Cologne's Ford factories.[6][7] Besides football, he was interested in popular science books, which he borrowed from the Catholic church library. Initially, his primary school teacher recommended that he attend a hauptschule, which would not have readily enabled him to attend university. Upon intervention of his German neighbour, he went to a gymnasium instead.[8][9][10] He graduated from the Erich-Kästner-Gymnasium in Cologne-Niehl in 1984, the first child at the school with Turkish guest worker parents. He took advanced courses in mathematics and chemistry.[11]

Şahin met his future wife, Özlem Türeci, during his work at the Saarland University Hospital (Universität des Saarlandes) in Homburg, where Türeci completed her last year of studies at the medical faculty. The couple married in 2002; they have one daughter.[12][13][14]

He and his wife are among the hundred richest people in Germany because of the value of their shareholding in BioNTech.[15] As of May 2021, Bloomberg Billionaires Index estimated his net worth at US$8.35 billion.[1]

Education[]

Şahin studied medicine at the University of Cologne from 1984 to 1992.[16][17] He received his doctorate in 1992 with a thesis on immunotherapy against tumor cells (bispecific monoclonal antibodies for the activation of cytostatic precursors on tumor cells), which was graded summa cum laude. His thesis supervisor was  [de]. From 1992 to 1994, he studied mathematics at the Fernuniversität Hagen.[18]

Career[]

Şahin worked as a physician for internal medicine and hematology/oncology from 1991 to 2000 at the  [de] chaired by Volker Diehl and then at the Saarland University Hospital in Homburg. He habilitated in 1999 in the field of molecular medicine and immunology. After one year sabbatical with  [de] at the Institute for Experimental Immunology of the University Hospital of Zürich in 2000, he joined Christoph Huber at the University Medical Center Mainz. There, he has been working in various leading positions in cancer research and immunology since 2001 and has been a professor for experimental oncology at the III. Department for Internal Medicine/Oncohematology since 2006.[19] Şahin sees himself as an immune engineer who tries to use the body's antiviral mechanisms to treat, for example, cancer when the immune system is otherwise unable to fight it. He sees his vision in guiding the immune system to "protect us from or alleviate certain diseases."[20][21]

University Medical Center Mainz[]

In 2000, Şahin became head of the junior research group of the SFB 432 of the  [de], and in 2003 chair of the Tumor Vaccine Center.[18][22] Since 2006 he has been a lecturer in the Department of Experimental and Translational Oncology. In 2010, he co-founded TRON (Translational Oncology at the University Medical Center of Johannes Gutenberg University Mainz). TRON is a non-profit (private) biopharmaceutical research institute that develops new diagnostic tools and drugs to treat cancer and other diseases with a high unmet medical need.[23] Its focus is on individualized medicine and cancer immunotherapy. For his work in this field, Şahin was awarded the  [de].[24][25]

From its foundation until September 2019, he was TRONs scientific director.[26] Since then, he has been working as a scientific advisor and supervisor of Ph.D. students.[27]

Further, Sahin is deputy director of the University Center for Tumor Diseases Mainz (UCT Mainz), founded in 2011.[28][29] The UCT Mainz is an association of all active institutions at the University Medical Center Mainz that focus on clinical oncology or oncological research.[30] In 2017, Sahin was involved in establishing the new Helmholtz Institute HI-TRON, which is a cooperation between the German Cancer Research Center (DKFZ) and TRON.[31][32][33]

He is one of the scientific directors of the new Helmholtz Institute.[34] During the founding ceremony, Şahin declared that he believes "cancer can be defeated in the future."[35] One of the projects that Sahin led at the University Medical Center for developing innovative vaccines against cancer was one of twelve projects awarded a sponsorship prize by the German Federal Ministry of Education and Research in 2006 as part of the newly created biotechnology start-up offensive (GO-Bio).

Ganymed Pharmaceuticals[]

Şahin co-founded the company Ganymed Pharmaceuticals in 2001 with his wife, Özlem Türeci and his mentor Christoph Huber.[36] Ganymed developed the monoclonal antibody Zolbetuximab, against esophageal and gastrointestinal cancer.[37] In 2016, after showing in a randomized clinical trial that this drug significantly boosted advanced gastric cancer patients' overall survival.[38] The company was sold to Astellas Pharma for an amount of triple-digit millions.[39] The drug is in Phase III as of 2020.[40][41][42]

BioNTech[]

Headquarters of BioNTech SE in Mainz

Together with Özlem Türeci and Christoph Huber, Şahin founded the biotechnology company BioNTech, based in Mainz, Germany, in 2008 and has been its CEO ever since.[43][44] BioNTech is focused on developing and manufacturing active immunotherapies for a patient-specific approach to the treatment of cancer and other serious diseases.[45] The main focus of his research work is the discovery of mRNA-based drugs for use as individualized cancer immunotherapies, as vaccines against infectious diseases, and as protein replacement therapies for rare diseases.[46] He holds a minority interest in the listed company.[47][48] Since April 2020, BioNTech has been researching a vaccine against the lung disease COVID-19 under Şahin and his wife Özlem Türeci, who is also a member of the company's board of directors.[49][50] Şahin is involved in several patents that he has filed with his company and partners.

Against the background of the debate about the distribution of a potential vaccine, Şahin stated that one key in the fight against COVID-19 is international cooperation and equality of distribution. He said there was "no discussion" about whether a vaccine would be made available exclusively to individual countries.[51][52] Şahin is against compulsory vaccination and emphasizes the voluntary nature of the vaccination.[53]

He also emphasizes that the efficacy and safety of a vaccine, including side effects, must always be communicated transparently. In fall 2020, he entered a partnership with the U.S. pharmaceutical company Pfizer and planned to obtain approval for a vaccine before the end of 2020.[54][55][56] In November, the company reported a 95 percent efficacy of the BNT162b2 vaccine.[57]

Research[]

Şahin works together with Özlem Türeci as a physician scientist couple since they met in 1992. Their early work focussed on identifying and characterizing new target molecules (antigens) for the immunotherapy of cancer. They discovered tumor antigens relevant for treatment of various types of cancers e.g. stomach cancer, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, lung cancer, and other dangerous cancers.[58][59][60]

Şahin and his team established the strategies that allow different layers of mRNA vaccine optimization: including optimizations of the various structural backbone elements of mRNA molecules, ways to utilize uridine-based as well as nucleoside-modified mRNA chemistries and different lipid-based compositions and administration routes to deliver mRNA. By systematically combining mRNA modifications, based on rational principles, achieved an exponential improvement in the potency of mRNA vaccines as well as its adaption to various purposes[61][62][63] reviewed in.[64][65] Building on this toolbox of groundbreaking improvements of RNA molecules Şahin moved on to successful utilization of mRNA for various applications in humans.

RNA Vaccines Targeting Individual Cancer Mutations[]

One application Sahin's team has pioneered are mRNA vaccines for personalized cancer therapy that are based on non-nucleoside modified mRNA. This technology relies on targeting tumor-specific mutations that are not present in normal cells. Each patient's tumor has a unique set of mutations. Since mRNA vaccines can be easily designed to target any antigen, the team could use the mutation fingerprint of cancers for engineering mRNA-based personalized neo-antigen vaccines. This application offers the possibility of targeting each patient's tumor mutations with an individually tailored mRNA vaccine of unique composition that is produced "on demand".

RNA Vaccines Targeting Tumor-Associated Antigens (TAAs)[]

To apply their RNA cancer vaccine to tumor-associated antigens shared between patients, Sahin and his team developed RNA vaccine nanoparticle delivery strategies that target tissue-derived dendritic cells body-wide. They moved from animal studies to clinical trials in humans, pioneering the first intravenous nanoparticle delivery of mRNA vaccines in humans. They observed strong tumor-antigen-specific immune responses induced by their uridine-based non-nucleoside modified mRNA vaccines, even though the utilized TAAs are self-antigens. This was a critical step toward the development of effective, potent cancer vaccines targeting a broad range of antigens for immunotherapy.

RNA Vaccines To Improve CAR-T Therapy (CARVAC)[]

Chimeric antigen receptor (CAR)-T cell therapies are highly promising immunotherapies for treating B-cell-derived hematologic cancers, but achieving long-term patient responses in solid tumors remains a challenge due to poor activity of CAR-T cells against solid cancer. Sahin and his team have developed ways to use RNA vaccine technology for in vivo expansion and enhanced engraftment of genetically engineered, adoptively transferred CAR-T cells. This has been effective in inducing regression of large tumors in challenging mouse cancer models, The approach is now in clinical trials for the treatment of patients with various cancers.

RNA Vaccines To Induce Antigen Specific Tolerance in Autoimmune Disease[]

Autoimmune diseases, such as multiple sclerosis (MS), result from tissue damage caused by self-reactive T lymphocytes. Combating autoimmune diseases is challenging and can lead to systemic immunosuppression and side effects such as increased risk of infection. Şahin and his team developed a novel therapeutic strategy that circumvents systemic immunosuppression by inhibiting only the immune cells that mediate autoimmune disease. They used a different version of lipid nanoparticles to deliver MS autoantigens encoded by a non-inflammatory RNA into dendritic cells. This approach expands a specific type of immune cells, called antigen-specific regulatory effector T cells, which suppress autoreactivity against the targeted autoantigens and also promote inhibition of autoreactive T cells against other myelin-specific autoantigens. The RNA vaccine used for tolerance induction contained 1-methylpseudouridine (m1Ψ) instead of uridine, a modification previously described by Kariko and colleagues that does not stimulate Toll-like receptors. In mouse models of MS, the novel RNA vaccine approach delayed onset and reduced severity of established disease without inducing generalized immunosuppression.[66][67][68]

RNA Vaccine Against COVID-19[]

In January 2020, when the world was confronted with the rapidly emerging SAR-CoV2 pandemic, Sahin and his teams pivoted from cancer to COVID-19 vaccine development. The rapid publication of the sequence of SARS-COV-2 enabled them to initiate an RNA vaccine discovery program. The versatile nature of their mRNA technology and the ground-work Sahin's team had done in the area of cancer vaccines allowed them to develop, produce, and test multiple mRNA vaccine candidates in parallel. BNT162b2 was discovered as the best candidate for the particular purpose of vaccinating for COVID19 prevention. BNT162b2 is a lipid nanoparticle encapsulated, nucleoside-modified RNA vaccine encoding SARS-CoV-2 spike protein and combines multiple features for optimized vaccine activity derived from Sahin, Türeci and their teams prior work.[69][70][71] Clinical trials and subsequent real-world studies established that BNT162b2 vaccine is very effective in inducing immune responses and proved the safety and potent efficacy in humans.[72][73][74] BNT162b2 became the first mRNA drug approved for human use and the fastest vaccine developed against a new pathogen in the history of medicine.[75]

Memberships[]

Şahin in 2019

Şahin has been a member of the  [de] since 2004, and a member of the Program Committee of the Association for Cancer Immunotherapy (CIMT), Regulatory Research Group, Mainz, since 2008. In 2012, he was among the founders of the Cluster of Individualized Immunointervention (CI3) in Mainz.[76][77] He has been a member of the American Association for Cancer Research (AACR) since 2014 and of the American Society of Clinical Oncology (ASCO) since 2015.[19] In 2021 Sahin was elected as member of the European Molecular Biology Organization (EMBO).

Publications[]

The U.S. National Library of Medicine lists 345 clinical studies and other publications where Şahin was involved; he is first author of 49.[78] The U.S. Patent and Trademark Office lists several patents related to him.[79]

Base on the top-cited patent over the past five years, and H-index, a calculation of the impact of a researcher's publications over time, Ugur Sahin was ranked in Nature Biotechnology's Top 20 translational researchers in the years of 2015,[80] 2018 and of 2019.[81]

Selection
  • Kowalska, J.; Wypijewska Del Nogal, A.; Darzynkiewicz, Z. M.; Buck, J.; Nicola, C.; Kuhn, A. N.; Lukaszewicz, M.; Zuberek, J.; Strenkowska, M.; Ziemniak, M.; MacIejczyk, M.; Bojarska, E.; Rhoads, R. E.; Darzynkiewicz, E.; Sahin, U.; Jemielity, J. (2014), "mRNA-based therapeutics–developing a new class of drugs.", Nature Reviews Drug Discovery, 13 (10), pp. 759–780, doi:10.1093/nar/gku757, PMC 4176373, PMID 25150148
  • Sahin, U.; et al. (2017), "Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.", Nature, 547 (7662): 222–226, Bibcode:2017Natur.547..222S, doi:10.1038/nature23003, PMID 28678784, S2CID 3757711
  • Polack, Fernando P.; Thomas, Stephen J.; Kitchin, Nicholas; Absalon, Judith; Gurtman, Alejandra; Lockhart, Stephen; Perez, John L.; Pérez Marc, Gonzalo; Moreira, Edson D.; Zerbini, Cristiano; Bailey, Ruth; Swanson, Kena A.; Roychoudhury, Satrajit; Koury, Kenneth; Li, Ping; Kalina, Warren V.; Cooper, David; Frenck, Robert W.; Hammitt, Laura L.; Türeci, Özlem; Nell, Haylene; Schaefer, Axel; Ünal, Serhat; Tresnan, Dina B.; Mather, Susan; Dormitzer, Philip R.; Şahin, Uğur; Jansen, Kathrin U.; Gruber, William C. (2020), "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", New England Journal of Medicine, 383 (27): 2603–15, doi:10.1056/NEJMoa2034577, hdl:10757/655958, PMC 7745181, PMID 33301246, S2CID 228087117
  • Miller, Joe; Şahin, Uğur; Türeci, Özlem (2021). Projekt Lightspeed: Der Weg zum BioNTech-Impfstoff [Project Lightspeed: The Road to the BioNTech Vaccine] (in German) (1st ed.). Hamburg: Rowohlt Verlag. p. 352. ISBN 978-3-498-00277-0.

Awards (selection)[]

References[]

  1. ^ Jump up to: a b c "Bloomberg Billionaires Index: Ugur Sahin". Bloomberg L.P. Retrieved 21 June 2021.
  2. ^ Hatice Akyün (26 April 2020). ""Wir sind Impfstoff": Über zwei Wissenschaftler, die nicht nur Hoffnung gegen das Virus machen" ["We are vaccine": Two Scientists give hope, and not just against the virus]. Der Tagesspiegel (in German). Retrieved 26 October 2020.
  3. ^ Johannes Göbel (26 March 2015). "Erfolgreiches "Mainzer Modell"" [Successful Mainz Model]. Deutschland-Portal (in German). Fazit Communication, German Federal Foreign Office. Retrieved 26 October 2020. The awards are to be given to them by President Frank-Walter Steinmeier at Bellevue Palace, the presidential residence on 19 March.
  4. ^ Philip Oltermann (10 November 2020). "Uğur Şahin and Özlem Türeci: German 'dream team' behind vaccine". The Guardian. Archived from the original on 17 January 2021. Retrieved 6 February 2021. The comments hinted at the scientific rigour, unrelenting work ethic and appetite for entrepreneurship that has seen Sahin and Türeci's company outpace more well-established competitors in the race for a Covid-19 vaccine – and made the couple the first Germans with Turkish roots to enter their country's rich list this autumn, at number 93.
  5. ^ Rauscher, Hans (18 December 2020). "Migration und Qualifikation - derStandard.at". Der Standard (in German). Retrieved 22 December 2020.
  6. ^ Franz Josef Wagner (7 October 2020). "Betrifft: Wir sind Impfstoff". B.Z. (in German) (234). B.Z. Ullstein. p. 18.
  7. ^ "Corona-Impfstoff könnte Biontech-Gründer Ugur Sahin weltberühmt machen". RTL (in German). 21 October 2020. Retrieved 26 October 2020.
  8. ^ Külahçı, Ahmet (18 November 2020). "'Der Retter kommt' (Kurtarıcı geliyor)". Hürriyet. Archived from the original on 29 November 2020. Retrieved 29 January 2021.
  9. ^ Rossmann, Ernst Dieter; Samsami, Behrang (2 December 2020). "Gemeinsam denken" [Thinking together]. Der Freitag. Archived from the original on 2 December 2020. Retrieved 30 January 2021.
  10. ^ Anne Seibring (11 December 2020). "Editorial". Bundeszentrale für politische Bildung. Retrieved 31 January 2021.
  11. ^ Bastian Ebel (11 November 2020), Stolz an Kölner Schule: Irrer Lebensweg: Ex-Abiturient wird in Corona-Zeit zum Weltstar [Pride at a Cologne School: Crazy Life Path: Former Student Becomes World Star in Corona Times] (in German), retrieved 20 November 2020
  12. ^ Tobias Stolzenberg (2018), "Zwei gegen den Krebs", Technology Review (in German), Hannover: Heise Verlag (5), retrieved 26 October 2020
  13. ^ SPIEGEL, Anton Rainer, DER. "Biontech-Impfstoff: Wie Google eine Impf-Forscherin zur "Ehefrau" macht". www.spiegel.de (in German). Retrieved 11 July 2021.
  14. ^ "Özlem Türeci". POLITICO. 7 December 2020. Retrieved 11 July 2021.
  15. ^ Rudnick, Hendrikje (11 November 2020). "Von Gastarbeiter-Kindern zu Milliardären: Biontech-Chef Ugur Sahin und seine Frau Özlem Türeci gehören zu den 100 reichsten Deutschen". Business Insider (in German). Retrieved 15 November 2020.
  16. ^ Balzter, Sebastian (21 August 2016). "Das Traumpaar der Biotech-Branche" [The Dream Couple of the Biotech Industry] (PDF). Frankfurter Allgemeine Sonntagszeitung (in German). p. 27. Retrieved 26 October 2020 – via hmw-emissionshaus.ag.
  17. ^ "Entwicklung innovativer Impfstoffe gegen Krebserkrankungen" [Development of innovative vaccines against cancer]. YouTube (in German). 10:47. Retrieved 26 October 2020.
  18. ^ Jump up to: a b Prof. Dr. Ugur Sahin, Mitglied des FZI (PDF), Forschungszentrum für Immuntherapie (FZI) der Johannes Gutenberg-Universität Mainz, retrieved 26 October 2020
  19. ^ Jump up to: a b c "Prof. Dr. med. Ugur Sahin", SFB 1399: Mechanisms of Drug Sensitivity and Resistance in Small Cell Lung Cancer, Department of Translational Genomics, University of Cologne, retrieved 26 October 2020
  20. ^ Stefan Groß-Lobkowicz (23 October 2020), "Corona-Impfstoff: Für 2020 haben wir bis zu 100 Millionen Dosen geplant.", The European (in German), Weimer Media Group, retrieved 26 October 2020
  21. ^ Petra Apfel (9 September 2015), "Größte Hoffnung seit Jahrzehnten: Individuelle Krebsimpfung tötet Tumore.", Focus Online (in German), retrieved 26 October 2020
  22. ^ "Ugur Sahin – Biography", ORCID, retrieved 26 October 2020
  23. ^ Über TRON (in German), TRON – Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz, retrieved 26 October 2020
  24. ^ Petra Spielberg (2019), "Ugur Sahin: Mit individualisierten Therapien gegen den Krebs.", Deutsches Ärzteblatt (in German) (116), retrieved 26 October 2020
  25. ^ Renée Dillinger-Reiter (28 February 2019), Professor Ugur Sahin erhält den Deutschen Krebspreis 2019 (in German), Universitätsmedizin Mainz, retrieved 26 October 2020
  26. ^ Management (in German), TRON – Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz, retrieved 26 October 2020
  27. ^ Neues Spitzenforschungsinstitut in Mainz: TRON – Translationale Onkologie. Bindeglied zwischen Universität, Universitätsmedizin und Wirtschaft., Ministerium für Wissenschaft, Weiterbildung und Kultur des Landes Rheinland-Pfalz, 18 February 2010, retrieved 26 October 2020
  28. ^ Geschäftsführung (in German), Universitäres Centrum für Tumorerkrankungen Mainz (UCT Mainz), retrieved 26 October 2020
  29. ^ CCC-Netzwerk der Deutschen Krebshilfe – Mitglieder – Mainz (in German), Stiftung Deutsche Krebshilfe, retrieved 26 October 2020
  30. ^ Uni Mainz hat neues Tumor-Zentrum. (in German), Berufsverband Deutscher Internisten, 22 June 2011, retrieved 26 October 2020
  31. ^ Renée Dillinger-Reiter (1 March 2017), Personalisierte Immuntherapie gegen Krebs (in German), Universitätsmedizin Mainz, retrieved 26 October 2020
  32. ^ Helmholtz-Institut für Translationale Onkologie Mainz (in German), Deutsches Krebsforschungszentrum, retrieved 26 October 2020
  33. ^ Präzisionsschlag gegen den Krebs (in German), Bundesministerium für Bildung und Forschung (BMBF). Sieg gegen Krebs nicht unmöglich., 14 February 2019, retrieved 26 October 2020
  34. ^ "Neues Helmholtz-Institut", Die Welt (in German), 14 February 2019, retrieved 26 October 2020
  35. ^ "Experte für Immuntherapie: Sieg gegen Krebs nicht unmöglich.", Frankfurter Allgemeine Zeitung (in German), ISSN 0174-4909, retrieved 26 October 2020
  36. ^ Joe Miller (20 March 2020), "Ugur Sahin: The Immunologist Racing To Find a Vaccine", Financial Times, retrieved 26 October 2020
  37. ^ Tobias Stolzenberg (8 October 2018), "Zwei gegen den Krebs", Heise Online (in German), retrieved 26 October 2020
  38. ^ "This Obscure Biotech May Have a Game-Changing Cancer Med On Its Hands". Fortune. Retrieved 30 June 2021.
  39. ^ "Astellas kauft Ganymed", Transkript (in German), 28 October 2016, retrieved 26 October 2020
  40. ^ Türeci, Ö.; Sahin, U.; Schulze-Bergkamen, H.; Zvirbule, Z.; Lordick, F. (26 June 2019), "A Multicentre, Phase Iia Study of Zolbetuximab as a Single Agent in Patients With Recurrent or Refractory Advanced Adenocarcinoma of the Stomach or Lower Oesophagus: The Mono Study", Annals of Oncology, 30 (9), pp. 1487–1495, doi:10.1093/annonc/mdz199, ISSN 1569-8041, PMC 6771222, PMID 31240302
  41. ^ Antibody Shines in Advanced Gastric Cancer, 5 June 2016, retrieved 26 October 2020
  42. ^ "A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma", ClinicalTrials, U.S. National Library of Medicine, retrieved 26 October 2020
  43. ^ Ministerpräsidentin Malu Dreyer sagt Mainzer Impfstoffentwickler BioNTech Unterstützung zu. (in German), Staatskanzlei Rheinland-Pfalz, 15 May 2020, retrieved 26 October 2020
  44. ^ "Ugur Sahin, Profile and Biography", Bloomberg, retrieved 26 October 2020
  45. ^ Hofmann, Siegfried; Terpitz, Katrin (16 March 2016), "Impfung gegen Krebs", Handelsblatt (in German), p. 16
  46. ^ Kutter, Susanne (3 June 2016), "Der große Schlag im Kampf gegen den Krebs", WirtschaftsWoche (in German) (23), p. 14
  47. ^ "BioNTech-Aktie", finanzen.net (in German), retrieved 26 October 2020
  48. ^ Wolfram Weimer (13 October 2020), "Der Impfstoff naht", n-tv (in German), retrieved 26 October 2020
  49. ^ Siegfried Hofmann, Christian Wermke (23 April 2020), "Ugur Sahin und Özlem Türeci: Dieses Medizinerpaar entwickelt einen Covid-19-Impfstoff.", Handelsblatt (in German), retrieved 26 October 2020
  50. ^ Gelles, David (10 November 2020). "The Husband-and-Wife Team Behind the Leading Vaccine to Solve Covid-19". The New York Times. Retrieved 17 November 2020.
  51. ^ Kopplin, Ilka; Schleidt, Daniel (16 March 2020), "Mainzer Unternehmen: Wie Biontech gegen Corona kämpft.", Frankfurter Allgemeine Zeitung (in German), retrieved 26 October 2020
  52. ^ Salz, Jürgen (8 September 2020), "Biontech-Chef Ugur Sahin: "Wir wollen keine Abkürzung gehen."", WirtschaftsWoche (in German), retrieved 26 October 2020
  53. ^ Fanny Jimenez (20 October 2020), "Biontech-CEO Ugur Sahin über den Corona-Impfstoff: "Wir haben unser Projekt 'Lightspeed' genannt, um klarzumachen: Wir vergeuden keine Zeit."", Business Insider (in German), finanzen, retrieved 26 October 2020
  54. ^ Paul R. La Monica (16 October 2020), "Pfizer May File for Early COVID-19 Vaccine Use – but Not Until After the Election", CNN Business, Cable News Network, A Warner Media Company, retrieved 26 October 2020
  55. ^ Bojan Pancevski, Jared S. Hopkins (22 October 2020), "How Pfizer Partner BioNTech Became a Leader in Coronavirus Vaccine Race. Small German Biotech Was a Niche Player in Futuristic Cancer Treatments—Then Pivoted When COVID-19 Broke Out in China.", The Wall Street Journal, Dow Jones & Company, ISSN 0099-9660, retrieved 26 October 2020
  56. ^ Jürgen Salz, Silke Wettach (9 September 2020), "Nach zähen Verhandlungen: EU kauft Millionen Dosen Impfstoff bei Biontech und Pfizer ein.", WirtschaftsWoche (in German), retrieved 26 October 2020
  57. ^ heise online, Biontech/Pfizer-Corona-Impfstoff: 95 Prozent Wirksamkeit nach Phase-3-Auswertung (in German), retrieved 24 November 2020
  58. ^ Reinhard, K.; Rengstl, B.; Oehm, P.; Michel, K.; Billmeier, A.; Hayduk, N.; Klein, O.; Kuna, K.; Ouchan, Y.; Wöll, S.; Christ, E.; Weber, D.; Suchan, M.; Bukur, T.; Birtel, M.; Jahndel, V.; Mroz, K.; Hobohm, K.; Kranz, L.; Diken, M.; Kühlcke, K.; Sahin, U.; Sahin, Ugur (2020), "An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors", Science, 367 (6476): 446–453, Bibcode:2020Sci...367..446R, doi:10.1126/science.aay5967, PMID 31896660, S2CID 209671821
  59. ^ Sahin, U.; Koslowski, M.; Dhaene, K.; Usener, D.; Brandenburg, G.; Seitz, G.; Huber, C.; Türeci, O. (2008), "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development", Clinical Cancer Research, 14 (23): 7624–7634, doi:10.1158/1078-0432.CCR-08-1547, PMID 19047087, S2CID 5543394
  60. ^ Stenner-Liewen, F.; Luo, G.; Sahin, U.; Tureci, O.; Koslovski, M.; Kautz, I.; Liewen, H.; Pfreundschuh, M. (2000), "Definition of tumor-associated antigens in hepatocellular carcinoma", Cancer Epidemiology, Biomarkers & Prevention, 9 (3): 285–290, PMID 10750667
  61. ^ Holtkamp, S.; Kreiter, S.; Selmi, A.; Simon, P.; Koslowski, M.; Huber, C.; Türeci, O.; Sahin, U. (2006), "Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells", Blood, 108 (13): 4009–4017, doi:10.1182/blood-2006-04-015024, PMID 16940422
  62. ^ Kreiter, S.; Selmi, A.; Diken, M.; Sebastian, M.; Osterloh, P.; Schild, H.; Huber, C.; Türeci, O.; Sahin, U. (2008), "Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals", Journal of Immunology (Baltimore, Md. : 1950), 180 (1): 309–318, doi:10.4049/jimmunol.180.1.309, PMID 18097032, S2CID 83698413
  63. ^ Kuhn, A. N.; Diken, M.; Kreiter, S.; Selmi, A.; Kowalska, J.; Jemielity, J.; Darzynkiewicz, E.; Huber, C.; Türeci, O.; Sahin, U. (2010), "Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo", Gene Therapy, 17 (8): 961–971, doi:10.1038/gt.2010.52, PMID 20410931, S2CID 647837
  64. ^ Sahin, U.; Karikó, K. (2014), "mRNA-based therapeutics--developing a new class of drugs", Nature Reviews. Drug Discovery, 13 (10): 759–780, doi:10.1038/nrd4278, PMID 25233993, S2CID 27454546
  65. ^ Beck, J. D.; Reidenbach, D.; Salomon, N.; Sahin, U.; Vormehr, M.; Kranz, L. M. (2021), "mRNA therapeutics in cancer immunotherapy", Molecular Cancer, 20 (1): 69, doi:10.1186/s12943-021-01348-0, PMC 8047518, PMID 33858437
  66. ^ Krienke, C.; Kolb, L.; Diken, E.; Streuber, M.; Kirchhoff, S.; Bukur, T.; Kranz, L. M.; Berger, H.; Petschenka, J.; Diken, M.; Kreiter, S.; Yogev, N.; Waisman, A.; Karikó, K.; Sahin, U.; Türeci, Özlem; Sahin, Ugur (2021), "A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis", Science, 371 (6525): 145–153, Bibcode:2021Sci...371..145K, doi:10.1126/science.aay3638, PMID 33414215, S2CID 231138578
  67. ^ Flemming, A. (2021), "mRNA vaccine shows promise in autoimmunity", Nature Reviews. Immunology, 21 (2): 72, doi:10.1038/s41577-021-00504-3, PMC 7802056, PMID 33437044
  68. ^ Wardell, C. M.; Levings, M. K. (2021), "mRNA vaccines take on immune tolerance", Nature Biotechnology, 39 (4): 419–421, doi:10.1038/s41587-021-00880-0, PMID 33785909, S2CID 232431542
  69. ^ "Corona-Impfung erklärt: So funktioniert der programmierbare BioNTech-Impfstoff". c't Magazin (in German). Retrieved 30 June 2021.
  70. ^ Orlandini von Niessen, A. G.; Poleganov, M. A.; Rechner, C.; Plaschke, A.; Kranz, L. M.; Fesser, S.; Diken, M.; Löwer, M.; Vallazza, B.; Beissert, T.; Bukur, V.; Kuhn, A. N.; Sahin, U. (2019), "Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3' UTRs Identified by Cellular Library Screening", Molecular Therapy : The Journal of the American Society of Gene Therapy, 27 (4): 824–836, doi:10.1016/j.ymthe.2018.12.011, PMC 6453560, PMID 30638957
  71. ^ Holtkamp, S.; Kreiter, S.; Selmi, A.; Simon, P.; Koslowski, M.; Huber, C.; Türeci, O.; Sahin, U. (2006), "Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells", Blood, 108 (13): 4009–4017, doi:10.1182/blood-2006-04-015024, PMID 16940422
  72. ^ Sahin, U.; et al. (2021), "BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans", Nature, 595 (7868): 572–577, doi:10.1038/s41586-021-03653-6, PMID 34044428, S2CID 235232604
  73. ^ Vogel, A. B.; et al. (2021), "BNT162b vaccines protect rhesus macaques from SARS-CoV-2", Nature, 592 (7853): 283–289, Bibcode:2021Natur.592..283V, doi:10.1038/s41586-021-03275-y, PMID 33524990, S2CID 231756922
  74. ^ Polack, F. P.; Thomas, S. J.; Kitchin, N.; Absalon, J.; Gurtman, A.; Lockhart, S.; Perez, J. L.; Pérez Marc, G.; Moreira, E. D.; Zerbini, C.; Bailey, R.; Swanson, K. A.; Roychoudhury, S.; Koury, K.; Li, P.; Kalina, W. V.; Cooper, D.; Frenck Jr, R. W.; Hammitt, L. L.; Nell, H.; Schaefer, A.; Ünal, S.; Tresnan, D. B.; Mather, S.; Dormitzer, P. R.; Şahin, U.; Jansen, K. U.; Gruber, W. C.; C4591001 Clinical Trial Group (2020), "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", The New England Journal of Medicine, 383 (27): 2603–2615, doi:10.1056/NEJMoa2034577, PMC 7745181, PMID 33301246
  75. ^ Ball, P. (2021), "The lightning-fast quest for COVID vaccines - and what it means for other diseases", Nature, 589 (7840): 16–18, Bibcode:2021Natur.589...16B, doi:10.1038/d41586-020-03626-1, PMID 33340018, S2CID 229324351
  76. ^ The Cluster for Individualized Immune Intervention (Ci3), retrieved 26 October 2020
  77. ^ Cluster für Individualisierte ImmunIntervention (Ci3) – BMBF Spitzencluster (in German), Bundesministerium für Bildung und Forschung (BMBF), retrieved 26 October 2020
  78. ^ "Advanced Search", ClinicalTrials, U.S. National Library of Medicine, retrieved 25 November 2020
  79. ^ "Advanced Search", Patent Full-Text and Image Database, U.S. Patent and Trademark Office, retrieved 25 November 2020
  80. ^ "Table 1 Top 20 translational researchers in 2015". Nature Biotechnology : The Science and Business of Biotechnology. ISSN 1546-1696.
  81. ^ Huggett, Brady; Paisner, Kathryn (1 December 2019). "Top 20 translational researchers of 2018". Nature Biotechnology. 37 (12): 1401–1402. doi:10.1038/s41587-019-0323-8. ISSN 1546-1696. PMID 31796919. S2CID 208613402.
  82. ^ Preisträger Vincenz-Czerny-Preis und deren Arbeiten (in German), Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie, retrieved 26 October 2020
  83. ^ Ugur Sahin, Managing Director (Science and Research) of Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz – Tron, University of Birmingham, retrieved 26 October 2020
  84. ^ "Erfolgreiche Suche nach Tumormarkern", Ärzte Zeitung (in German), Springer Medizin, 13 October 2005, retrieved 26 October 2020
  85. ^ Koehler-Preis (in German), Deutsche Gesellschaft für Immunologie, 20 June 2018, retrieved 26 October 2020
  86. ^ GO-Bio Erfolge (in German), Bundesministerium für Bildung und Forschung (BMBF), retrieved 26 October 2020
  87. ^ "Prof. Ugur Sahin, MD PhD", ISCOMS, International Student Congress of (Bio)medical Sciences, retrieved 26 October 2020
  88. ^ Prof. Ugur Sahin Receives Prestigious European Research Council (ERC) Advanced Grant for Personalized Cancer Vaccines (in German), Mainzer Wissenschaftsallianz, 19 April 2018, retrieved 26 October 2020
  89. ^ The 2019 Mustafa Prize Laureates, retrieved 26 October 2020
  90. ^ Viermal Deutscher Krebspreis für DKTK Wissenschaftler (in German), Deutsches Konsortium für Translationale Krebsforschung (DKTK) – Deutsches Krebsforschungszentrum, 28 February 2019, retrieved 26 October 2020
  91. ^ "Deutscher Nachhaltigkeitspreis: Startseite". Deutscher Nachhaltigkeitspreis (in German). Retrieved 17 December 2020.
  92. ^ Miller, Joe; Cookson, Clive (16 December 2020). "FT People of the Year: BioNTech's Ugur Sahin and Ozlem Tureci". Financial Times. Retrieved 17 December 2020.
  93. ^ Hessler, Uwe; Wrede, Insa. "BioNTech vaccine inventors receive Germany's Knight Commander's Cross | DW | 19 March 2021". DW.COM.
  94. ^ "Bundespräsident ehrt Özlem Türeci und Uğur Şahin mit Verdienstorden" [Federal President honors Özlem Türeci and Uğur Şahin with Order of Merit]. bundespraesident.de (in German). Retrieved 30 June 2021.
  95. ^ "HoF - Hall of Fame (Laureates)". emdgroup.com. Retrieved 30 June 2021.
  96. ^ "THEOPHANO FOUNDATION - PRIZE 2021". theophano.eu. Retrieved 30 June 2021.
  97. ^ "Silicon Valley 2021 Awards". PMWC Precision Medicine World Conference. Retrieved 30 June 2021.
  98. ^ "EMBO announces 64 newly elected members – Press releases – EMBO". Retrieved 30 June 2021.
  99. ^ Princess of Asturias Award 2021

External links[]

Retrieved from ""