18-Hydroxycorticosterone

18-Hydroxycorticosterone
Names
	Preferred IUPAC name (1S,3aS,3bS,9aR,9bS,10S,11aR)-10-Hydroxy-1-(hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one
Identifiers
CAS Number	561-65-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16485 ;
ChemSpider	10748 ;
ECHA InfoCard	100.008.384
MeSH	18-hydroxycorticosterone
PubChem CID	11222;
UNII	4U5T0O9SI3 ;
CompTox Dashboard (EPA)	DTXSID80897516 ;
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Properties
Chemical formula	C21H30O5
Molar mass	362.46 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references

18-Hydroxycorticosterone is an endogenous steroid.^[1]^[2] It is a derivative of corticosterone.^[3]^[4]^[5]

Function[]

Corticosteroid biosynthetic pathway in rat^{[citation needed]}

18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa.

^ Reddish MJ, Guengerich FP (August 2019). "Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone". The Journal of Biological Chemistry. 294 (35): 12975–12991. doi:10.1074/jbc.RA119.009830. PMC 6721951. PMID 31296661.
^ Mulatero P, di Cella SM, Monticone S, Schiavone D, Manzo M, Mengozzi G, Rabbia F, Terzolo M, Gomez-Sanchez EP, Gomez-Sanchez CE, Veglio F (March 2012). "18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes". The Journal of Clinical Endocrinology and Metabolism. 97 (3): 881–9. doi:10.1210/jc.2011-2384. PMID 22238407.
^ Gupta V (October 2011). "Mineralocorticoid hypertension". Indian Journal of Endocrinology and Metabolism. 15 Suppl 4 (8): S298–312. doi:10.4103/2230-8210.86972. PMC 3230101. PMID 22145132.
^ Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM (September 2004). "Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects". The Journal of Clinical Endocrinology and Metabolism. 89 (9): 4628–33. doi:10.1210/jc.2004-0379. PMC 1283128. PMID 15356073.
^ Izumi Y (July 2010). "[18-Hydroxycorticosterone (18-OH-B)]". Nihon Rinsho. Japanese Journal of Clinical Medicine (in Japanese). 68 Suppl 7: 348–53. PMID 20960793.

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