Potassium canrenoate Other names SC-14266 AHFS /Drugs.com International Drug Names Routes of administration Intravenous ATC code Metabolism Hepatic Excretion Renal and fecal
potassium 3-[(8R ,9S ,10R ,13S ,14S ,17R )- 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H -cyclopenta[a] phenanthren-17-yl]propanoate
CAS Number PubChem CID DrugBank ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.016.868 Formula C 22 H 29 K O 4 Molar mass 396.568 g·mol−1 3D model (JSmol )
[K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1
Y Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M
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Potassium canrenoate (INN , JAN ) or canrenoate potassium (USAN ) (brand names Venactone , Soldactone ), also known as aldadiene kalium ,[1] the potassium salt of canrenoic acid , is an aldosterone antagonist of the spirolactone group.[2] Like spironolactone , it is a prodrug , and is metabolized to active canrenone in the body.[3] [4]
Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous )[4] [5] as opposed to oral administration .[6]
In the UK it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.
See also [ ]
References [ ]
Diuretics (C03 )
Sulfonamides (and etacrynic acid )
CA inhibitors (at PT )Loop (Na-K-Cl at AL )
Furosemide #
Azosemide
Bumetanide
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Amiloride #
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# WHO-EM
‡ Withdrawn from market
Clinical trials :
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# WHO-EM
‡ Withdrawn from market
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Mineralocorticoid receptor modulators
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List of corticosteroids
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Androgens (incl. AAS )
AR agonists
Testosterone derivatives: Androstenediol dipropionate
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# WHO-EM
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Clinical trials :
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MR
Agonists
11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
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PR
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RU-2309
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SC-8109
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See also
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List of progestogens
AR
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AA560
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See also
Receptor/signaling modulators
Androgens and antiandrogens
Estrogen receptor modulators
Progesterone receptor modulators
List of androgens/anabolic steroids