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New York crime family founders Joseph Profaci and Vincent Mangano arrive in the United States from Palermo, Sicily.
, an associate of Francesco "Frank 'The Enforcer' Nitti" Nitto, is indicted for murder, however is later found acquitted. On Nitti's behalf, Romano would later assume control of the Chicago Bartender and Beverage Dispenser's Union, Local 278.
May 11 – Timothy D. "Big Tim" Murphy, Cornelius Shea and six other labor leaders are indicted for murdering a Chicago policeman. The state withdraws the indictment in August for lack of evidence.
May 8 – Vincenzo Terranova is killed outside his home, most likely by Rocco Valenti.
July 9 – Joseph Peter DiCarlo, co-founder and then-boss of the present day Buffalo crime family, dies of natural causes and is succeeded by longtime (1922–1974) boss Stefano Magaddino.
August 9 – Umberto Valenti, a leading member of the Morello crime family, attempts to assassinate Joe Masseria after killing his two bodyguards, and upon cornering Masseria in a Second Avenuemillinery shop Masseria manages to escape. Two days later, during peace negotiations with Morrello and Messeria, Valenti is killed by Charles Luciano outside a Twelfth Street restaurant while trying to escape an apparent attempt on his life. During the shootout an eight-year-old girl and a street cleaner are wounded.
