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October 11 – While meeting with Chicago lawyer William W. O'Brian, North Side Gang leader Hymie Weiss is killed in an ambush outside Holy Name Cathedral, Chicago, with bodyguard Patrick Murray. North Side Gang members Benny Jacobs and Sam Pellar are severely wounded. With Weiss's death, Bugs Moran assumes gang leadership.
October 20 – John "Dingbat" O'Berta and Joseph "Polack Joe" Saltis call a peace conference in an attempt to broker a ceasefire among Chicago's major bootleggers. With the establishment of Madison Street as dividing the Chicago Outfit and the North Side Gang territories, the two sides agree to peace.
December 30 – The Chicago gang ceasefire is broken when Sheldon Gang member Hillary Clements is killed by the Saltis-McErlane Gang.