APUD cell
APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist , who developed the APUD concept in the early 1960s. These cells share the common function of secreting a low molecular weight polypeptide hormone. There are several different types which secrete the hormones secretin, cholecystokinin and several others. The name is derived from an acronym, referring to the following:[1][2]
- Amine Precursor Uptake – for high uptake of amine precursors including 5-hydroxytryptophan (5-HTP) and dihydroxyphenylalanine (DOPA).[2]
- Decarboxylase – for high content of the enzyme amino acid decarboxylase (for conversion of precursors to amines).
Cells in APUD system[]
- Adenohypophysis
- Neurons of Hypothalamus
- C-cells of Thyroid
- Chief Cells of Parathyroid
- Adrenal Medullary Cells
- Glomus cells in Carotid Body
- Melanocytes of Skin
- Cells of Pineal Gland
- Renin producing cells in Kidney
See also[]
References[]
- ^ Welbourn RB (January 1977). "Current status of the apudomas". Ann. Surg. 185 (1): 1–12. doi:10.1097/00000658-197701000-00001. PMC 1396259. PMID 12724.
- ^ a b Pearse, A.G. (1969). "The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept". J. Histochem. Cytochem. 17 (5): 303–13. doi:10.1177/17.5.303. PMID 4143745.
External links[]
- APUD+Cells at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Endocrine cells
- Cell biology stubs