Boldenone

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Not to be confused with 1-Testosterone.
Boldenone
Boldenone Structural Formula V.1.svg
Boldenone molecule ball.png
Clinical data
Other namesΔ1-Testosterone; 1-Dehydrotestosterone; RU-18761; Androsta-1,4-dien-17β-ol-3-one
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • X (US)
    X (AUS)
Routes of
administration		Intramuscular injection
Drug classAndrogen; Anabolic steroid
ATC code
  • None
Legal status
Legal status
  • CA: Schedule IV
  • UK: POM (Prescription only)
  • US: Schedule III
Pharmacokinetic data
Elimination half-lifeIntramuscular: 14 days (as boldenone undecylenate)[1]
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.533 Edit this at Wikidata
Chemical and physical data
FormulaC19H26O2
Molar mass286.415 g·mol−1
3D model (JSmol)
Melting point165 °C (329 °F)
SMILES
InChI
 ☒NcheckY (what is this?)  

Boldenone (developmental code name RU-18761), is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone.[2][3][4][5][6] Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[2][3][6]

Side effects[]

See also: Anabolic steroid § Adverse effects

Pharmacology[]

Pharmacodynamics[]

Like other AAS, boldenone is an agonist of the androgen receptor (AR).[6] The activity of boldenone is mainly anabolic, with a low androgenic potency. Boldenone will increase nitrogen retention, protein synthesis, increases appetite and stimulates the release of erythropoietin in the kidneys.[7] Boldenone was synthesized in an attempt to create a long-acting injectable metandienone, for androgen deficiency disorders. Boldenone acts similar to metandienone with fewer adverse androgenic effects.[medical citation needed] Although commonly compared to nandrolone, boldenone lacks progesterone receptor interaction and associated progestogenic side effects.

Chemistry[]

See also: List of androgens/anabolic steroids

Boldenone, also known as Δ1-testosterone, 1-dehydrotestosterone, or androsta-1,4-dien-17β-ol-3-one, is a naturally occurring androstane steroid and a derivative of testosterone.[2][3][6] It is specifically testosterone with a double bond between the C1 and C2 positions.[2][3][6] A related compound is quinbolone, the 17-cyclopentenyl enol ether of boldenone.[2][3]

Sources[]

Boldenone occurs naturally in the scent gland of Ilybius fenestratus, a species of aquatic beetle.[2]

History[]

Ciba reportedly patented boldenone in 1949.[6] It subsequently developed several experimental esters of the drug in the 1950s and 1960s.[6] One of these was boldenone undecylenate, which was introduced for clinical use under the brand name Parenabol and saw some use in the late 1960s and early 1970s.[6] However, it was discontinued before the end of the 1970s.[6] Subsequently, boldenone undecylenate was introduced by Squibb under the brand name Equipose for veterinary use, most commonly in horses.[6]

Society and culture[]

Generic names[]

Boldenone is the generic name of the drug and its INN and BAN.[2][3][4][5]

Brand names[]

Boldenone is marketed as veterinary drug as boldenone undecylenate (a derivative of boldenone) under the following brand names: Boldebal H, Equipoise, and Sybolin.[5] It is marketed as a veterinary combination drug with methandriol under the brand name Drive.[5]

In Ukraine, it is marketed for human consumption as the injectable steroid Boldenol.[8]

Doping in sports[]

See also: List of doping in sport cases § Boldenone undecylenate

There are many known cases of doping in sports with boldenone undecylenate by professional athletes.

References[]

  1. ^ Ruiz P, Strain EC (2011). Lowinson and Ruiz's Substance Abuse: A Comprehensive Textbook. Lippincott Williams & Wilkins. pp. 358–. ISBN 978-1-60547-277-5.
  2. ^ Jump up to: a b c d e f g Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 640–. ISBN 978-1-4757-2085-3.
  3. ^ Jump up to: a b c d e f Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 131–. ISBN 978-3-88763-075-1.
  4. ^ Jump up to: a b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 52–. ISBN 978-94-011-4439-1.
  5. ^ Jump up to: a b c d "Boldenone international brand names". Drugs.com. Retrieved 28 April 2017.
  6. ^ Jump up to: a b c d e f g h i j Llewellyn W (2011). Anabolics. Molecular Nutrition Llc. pp. 483–490. ISBN 978-0-9828280-1-4.
  7. ^ Forbes GB (June 1985). "The effect of anabolic steroids on lean body mass: the dose response curve". Metabolism: Clinical and Experimental. 34 (6): 571–3. doi:10.1016/0026-0495(85)90196-9. PMID 3999979.
  8. ^ Lyka Labs. "Boldenol 200 (boldenone undecylenate)". Retrieved 15 January 2020.

External links[]

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