Climbazole

Climbazole
Clinical data
Routes of; administration	topical
ATC code	none;
Identifiers
	show IUPAC name
CAS Number	38083-17-9 ;
PubChem CID	37907;
ChemSpider	34752 ;
UNII	9N42CW7I54;
ChEBI	CHEBI:83499 ;
ChEMBL	ChEMBL1437764 ;
CompTox Dashboard (EPA)	DTXSID6046555 ;
ECHA InfoCard	100.048.870
Chemical and physical data
Formula	C15H17ClN2O2
Molar mass	292.76 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	show SMILES
	show InChI
	(what is this?)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff^[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against that appear to play an important role in the pathogenesis of dandruff.^[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations[]

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects[]

May cause localized irritation of the skin with symptoms including redness, rashes and itching.^{[citation needed]}

References[]

^ Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
^ Jump up to: ^a ^b Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.

[1] Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine

[pmid11534318-2] Jump up to: ^a ^b Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.

[1]

[2]

Clinical data

Routes of administration	topical
ATC code	none
Identifiers
show IUPAC name (RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one^[1]
CAS Number	38083-17-9^Y
PubChem CID	37907
ChemSpider	34752^N
UNII	9N42CW7I54
ChEBI	CHEBI:83499^N
ChEMBL	ChEMBL1437764^N
CompTox Dashboard (EPA)	DTXSID6046555
ECHA InfoCard	100.048.870
Chemical and physical data
Formula	C₁₅H₁₇ClN₂O₂
Molar mass	292.76 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
show SMILES CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl
show InChI InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3^N Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N^N
^NY (what is this?)