EIF4A2

EIF4A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BOR
Identifiers
Aliases	EIF4A2, BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II, eukaryotic translation initiation factor 4A2
External IDs	OMIM: 601102 MGI: 106906 HomoloGene: 1487 GeneCards: EIF4A2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,789,897 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,932,886 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; cerebellum; ; dorsolateral prefrontal cortex; ; caudate nucleus; ; cerebellar vermis; ; neocortex; ; cerebellar hemisphere; ; postcentral gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; translation initiation factor activity; GO:0008026 helicase activity; GO:0001948 protein binding; nucleic acid binding; hydrolase activity; ATP binding; ATPase activity; RNA binding;
Cellular component	cytosol; perinuclear region of cytoplasm; eukaryotic translation initiation factor 4F complex; nucleolus;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; RNA secondary structure unwinding; GO:0022415 viral process; negative regulation of RNA-directed 5'-3' RNA polymerase activity; protein biosynthesis; regulation of translational initiation; translational initiation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	1974
	13682
	ENSG00000156976
	ENSMUSG00000022884
	Q14240
	P10630
	NM_001967
	NM_001123037; NM_001123038; NM_013506; NM_001347179
	NP_001958
	NP_001116509; NP_001116510; NP_001334108; NP_038534
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156976 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022884 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet. 71 (4): 385–8. doi:10.1159/000134145. PMID 8521730.
^ "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2".

External links[]

Overview of all the structural information available in the PDB for UniProt: Q14240 (Human Eukaryotic initiation factor 4A-II (EIF4A2)) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156976 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022884 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8521730-5] Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet. 71 (4): 385–8. doi:10.1159/000134145. PMID 8521730.

[entrez-6] "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2".

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EIF4A2

References[]

Further reading[]

External links[]