MRPS24

MRPS24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS24, MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24
External IDs	OMIM: 611986 MGI: 1928142 HomoloGene: 57043 GeneCards: MRPS24
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,869,893 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,665,680 bp
RNA expression pattern
	Top expressed in
	muscle tissue; ; heart; ; muscle of leg; ; body of stomach; ; gastrocnemius muscle; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; mitochondrial translation; biological process;
	Sources:Amigo / QuickGO
Orthologs
	64951
	64660
	ENSG00000062582
	ENSMUSG00000020477
	Q96EL2
	Q9CQV5
	NM_032014
	NM_026080; NM_001362871
	NP_114403
	NP_080356; NP_001349800
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.^[5]^[6]^[7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000062582 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020477 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC 307856. PMID 8127713.
^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
^ ^a ^b "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

External links[]

Overview of all the structural information available in the PDB for UniProt: Q96EL2 (28S ribosomal protein S24, mitochondrial) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000062582 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020477 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8127713-5] Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC 307856. PMID 8127713.

[pmid11279123-6] Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.

[entrez-7] "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

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MRPS24

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