Fenticlor
![]() | |
Clinical data | |
---|---|
Routes of administration | topical |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.002.336 ![]() |
Chemical and physical data | |
Formula | C12H8Cl2O2S |
Molar mass | 287.15 g·mol−1 |
Melting point | 174 °C (345 °F) |
Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine.
Synthesis[]
It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride.[1] It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.[2][3]
Safety[]
LD50 (rats, oral) = 3250 mg/kg.[1] It may cause photosensitivity[4]
References[]
- ^ a b Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313.
- ^ DE 568944, Muth F, "Verfahren zur Darstellung von Bis-(halogen-oxyaryl)-sulfiden", issued 1931, assigned to I. G. Farben
- ^ Dunning F, Dunning B, Drake WE (1931). "Preparation and Bacteriological Study of Some Symmetrical Organic Sulfides". Journal of the American Chemical Society. 53 (9): 3466. doi:10.1021/ja01360a035.
- ^ Burry JN (June 1974). "Letter: Fenticlor, actinic reticuloid, and antihistamines". British Medical Journal. 2 (5918): 556–7. doi:10.1136/bmj.2.5918.556-c. PMC 1610938. PMID 4152080.
Categories:
- Antifungals
- Antiseptics
- Phenols
- Thioethers
- Chloroarenes
- Alcohol stubs