From Wikipedia, the free encyclopedia
Gem-associated protein 2 (GEMIN2 ), also called survival of motor neuron protein-interacting protein 1 (SIP1 ), is a protein that in humans is encoded by the GEMIN2 gene .[5] [6] [7]
Interactions [ ] Gem-associated protein 2 has been shown to interact with DDX20 [8] [9] SMN1 .[6] [10] [11]
See also [ ] References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000092208 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060121 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis" . Cell . 90 (6): 1023–9. doi :10.1016/S0092-8674(00)80368-2 PMID 9323130 . ^ a b Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013–21. doi :10.1016/S0092-8674(00)80367-0 PMID 9323129 . ^ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1" .^ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri ; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" . Genes Dev . 16 (6): 720–8. doi :10.1101/gad.974702 . ISSN 0890-9369 . PMC 155365 PMID 11914277 . ^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems" . J. Cell Biol . 147 (6): 1181–94. doi :10.1083/jcb.147.6.1181 . ISSN 0021-9525 . PMC 2168095 PMID 10601333 . ^ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs" . J. Cell Sci . 116 (Pt 10): 1905–13. doi :10.1242/jcs.00409 ISSN 0021-9533 . PMID 12668731 . ^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins" . Hum. Mol. Genet . 9 (13): 1977–86. doi :10.1093/hmg/9.13.1977 ISSN 0964-6906 . PMID 10942426 .
Further reading [ ]
Wang Z, Wu X, Friedberg EC (1997). "Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts" . J. Biol. Chem . 272 (38): 24064–71. doi :10.1074/jbc.272.38.24064 PMID 9295360 . Zhang WJ, Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing" . Mol. Cell. Biol . 18 (2): 676–84. doi :10.1128/mcb.18.2.676 . PMC 108778 PMID 9447963 . Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems" . J. Cell Biol . 147 (6): 1181–94. doi :10.1083/jcb.147.6.1181 . PMC 2168095 PMID 10601333 . Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli" . J. Cell Biol . 148 (6): 1177–86. doi :10.1083/jcb.148.6.1177 . PMC 2174312 PMID 10725331 . Helmken C, Wetter A, Rudnik-Schöneborn S, et al. (2000). "An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA)" . Eur. J. Hum. Genet . 8 (7): 493–9. doi :10.1038/sj.ejhg.5200479 PMID 10909848 . Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins" . Hum. Mol. Genet . 9 (13): 1977–86. doi :10.1093/hmg/9.13.1977 PMID 10942426 . Young PJ, Man NT, Lorson CL, et al. (2001). "The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding" . Hum. Mol. Genet . 9 (19): 2869–77. doi :10.1093/hmg/9.19.2869 PMID 11092763 . Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A Functional Interaction between the Survival Motor Neuron Complex and RNA Polymerase II" . J. Cell Biol . 152 (1): 75–85. doi :10.1083/jcb.152.1.75 . PMC 2193649 PMID 11149922 . Jablonka S, Bandilla M, Wiese S, et al. (2001). "Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy" . Hum. Mol. Genet . 10 (5): 497–505. doi :10.1093/hmg/10.5.497 PMID 11181573 . Friesen WJ, Massenet S, Paushkin S, et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets" . Mol. Cell . 7 (5): 1111–7. doi :10.1016/S1097-2765(01)00244-1 PMID 11389857 . Park JW, Voss PG, Grabski S, et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein" . Nucleic Acids Res . 29 (17): 3595–602. doi :10.1093/nar/29.17.3595 . PMC 55878 PMID 11522829 . Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins" . Mol. Cell. Biol . 21 (24): 8289–300. doi :10.1128/MCB.21.24.8289-8300.2001 . PMC 99994 PMID 11713266 . Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . J. Biol. Chem . 277 (7): 5631–6. doi :10.1074/jbc.M109448200 PMID 11714716 . Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . J. Biol. Chem . 277 (9): 7540–5. doi :10.1074/jbc.M110141200 PMID 11748230 . Aerbajinai W, Ishihara T, Arahata K, Tsukahara T (2002). "Increased expression level of the splicing variant of SIP1 in motor neuron diseases". Int. J. Biochem. Cell Biol . 34 (6): 699–707. doi :10.1016/S1357-2725(01)00150-9 . PMID 11943600 . Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . J. Biol. Chem . 277 (35): 31957–62. doi :10.1074/jbc.M203478200 PMID 12065586 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
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