SMC1B

SMC1B
Identifiers
Aliases	SMC1B, SMC1BETA, SMC1L2, structural maintenance of chromosomes 1B
External IDs	OMIM: 608685 MGI: 2154049 HomoloGene: 13786 GeneCards: SMC1B
Gene location (Human)
Chr.	Chromosome 22 (human)
End	45,413,619 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,016,165 bp
RNA expression pattern
	Top expressed in
	testicle; ; ovary; ; multicellular organism; ; bone marrow; ; lymph node; ; thymus; ; Achilles tendon;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP binding;
Cellular component	lateral element; condensed nuclear chromosome; synaptonemal complex; chromosome, centromeric region; nuclear meiotic cohesin complex; nucleus; nucleoplasm; chromosome; meiotic cohesin complex; cytosol;
Biological process	cell cycle; GO:0007126 meiosis; chromosome organization; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	27127
	140557
	ENSG00000077935
	ENSMUSG00000022432
	Q8NDV3
	Q920F6
	NM_001291501; NM_148674
	NM_080470
	NP_001278430; NP_683515
	NP_536718
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene.^[5]^[6]^[7] SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis.^[7] SMC1ß protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human oocytes.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077935 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022432 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: structural maintenance of chromosomes 1B".
^ Dunham I; Shimizu N; Roe BA; Chissoe S; Hunt AR; Collins JE; Bruskiewich R; Beare DM; Clamp M; Smink LJ; Ainscough R; Almeida JP; Babbage A; Bagguley C; Bailey J; Barlow K; Bates KN; Beasley O; Bird CP; Blakey S; Bridgeman AM; Buck D; Burgess J; Burrill WD; O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ ^a ^b Revenkova E; Eijpe M; Heyting C; Gross B; Jessberger R (October 2001). "Novel meiosis-specific isoform of mammalian SMC1". Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMC 99874. PMID 11564881.
^ Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M (2010). "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes". Hum. Reprod. 25 (9): 2316–27. doi:10.1093/humrep/deq180. PMID 20634189.

Further reading[]

Zhang X, Yang H, Lee JJ, et al. (2010). "MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer". Carcinogenesis. 31 (12): 2118–23. doi:10.1093/carcin/bgq177. PMC 3105587. PMID 20819778.
Cobbe N; Heck MM (2004). "The evolution of SMC proteins: phylogenetic analysis and structural implications". Mol. Biol. Evol. 21 (2): 332–47. doi:10.1093/molbev/msh023. PMID 14660695.
Prieto I, Tease C, Pezzi N, et al. (2004). "Cohesin component dynamics during meiotic prophase I in mammalian oocytes". Chromosome Res. 12 (3): 197–213. doi:10.1023/B:CHRO.0000021945.83198.0e. PMID 15125634. S2CID 411379.
Lee J; Iwai T; Yokota T; Yamashita M (2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". J. Cell Sci. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077935 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022432 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: structural maintenance of chromosomes 1B".

[pmid10591208-6] Dunham I; Shimizu N; Roe BA; Chissoe S; Hunt AR; Collins JE; Bruskiewich R; Beare DM; Clamp M; Smink LJ; Ainscough R; Almeida JP; Babbage A; Bagguley C; Bailey J; Barlow K; Bates KN; Beasley O; Bird CP; Blakey S; Bridgeman AM; Buck D; Burgess J; Burrill WD; O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[pmid11564881-7] Revenkova E; Eijpe M; Heyting C; Gross B; Jessberger R (October 2001). "Novel meiosis-specific isoform of mammalian SMC1". Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMC 99874. PMID 11564881.

[pmid20634189-8] Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M (2010). "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes". Hum. Reprod. 25 (9): 2316–27. doi:10.1093/humrep/deq180. PMID 20634189.

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