SMC2

SMC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4U4P
Identifiers
Aliases	SMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDs	OMIM: 605576 MGI: 106067 HomoloGene: 4705 GeneCards: SMC2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	104,141,419 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	52,488,260 bp
RNA expression pattern
	Top expressed in
	lung; ; heart; ; kidney; ; stomach; ; ovary; ; Achilles tendon; ; testicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GO:0001948 protein binding; protein heterodimerization activity; ATP binding; single-stranded DNA binding;
Cellular component	cytoplasm; cytosol; chromosome; nucleoplasm; condensin complex; nuclear chromosome; nucleolus; extracellular exosome; condensed chromosome; nucleus;
Biological process	kinetochore organization; meiotic chromosome condensation; chromosome organization; meiotic chromosome segregation; cell division; chromosome condensation; cell cycle; mitotic chromosome condensation;
	Sources:Amigo / QuickGO
Orthologs
	10592
	14211
	ENSG00000136824
	ENSMUSG00000028312
	O95347; Q05D74
	Q8CG48
	NM_001042550; NM_001042551; NM_001265602; NM_006444
	NM_001301412; NM_008017
	NP_001036015; NP_001036016; NP_001252531; NP_006435; NP_006435.2
	NP_001288341; NP_032043
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.^[5]^[6]

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Interactions[]

SMC2 has been shown to interact with DNMT3B.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136824 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028312 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12906–11. Bibcode:1998PNAS...9512906S. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
^ "Entrez Gene: SMC2 structural maintenance of chromosomes 2".
^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

External links[]

PDBe-KB provides an overview of all the structure information available in the PDB for Human Structural maintenance of chromosomes protein 2
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Structural maintenance of chromosomes protein 2

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136824 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028312 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9789013-5] Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12906–11. Bibcode:1998PNAS...9512906S. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.

[entrez-6] "Entrez Gene: SMC2 structural maintenance of chromosomes 2".

[pmid15148359-7] Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

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SMC2

Contents

Interactions[]

References[]

Further reading[]

External links[]