Haplogroup W (mtDNA)

Haplogroup W
Haplogroup W
Possible time of origin	23,900 ybp
Possible place of origin	Western Asia
Ancestor	N2
Descendants	W1, C194T, W3, W4, W5, W6, W7
Defining mutations	195 204 207 1243 3505 5460 8251 8994 11947 15884C 16292

Haplogroup W is a human mitochondrial DNA (mtDNA) haplogroup.

Origin[]

Haplogroup W is believed to have originated around 23,900 years ago in Western Asia.^[1] It is descended from the haplogroup N2.

Distribution[]

Projected spatial distribution of haplogroup W.

Haplogroup W is found in Europe, Western Asia, and South Asia.^[3] It is widely distributed at low frequencies, with a high concentration in Northern Pakistan.^[4] Haplogroup W is also found in the Maghreb among Algerians (1.08%-3.23%)^[5] and in Siberia among Yakuts (6/423 = 1.42%^[6]).

Additionally, the clade has been observed among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Ptolemaic Kingdom.^[7]

The W5 subclade has been found in a fossil associated with the Starčevo culture (Lánycsók site; 1/1 or 100%).^[8]

Ancient DNA analysis found that the medieval individual Sungir 6 (730-850 cal BP) belonged to the W3a1 subclade.^[9]

Subclades[]

Tree[]

Phylogenetic tree of haplogroups I (left) and W (right). Kya in the left scale bar stands for thousand years ago.

This phylogenetic tree of haplogroup W subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation^[2] and subsequent published research.

W
- W1
  - W1a
  - W1b
  - T119C
    - W1c
      - W1c1
  - W1d
  - W1e
  - W1f
  - W1g
  - C194T
    - W3
      - W3a
        W3a1
        W3a1a
        W3a1a1
        
        W3a1b
        T199C
        W3a1c
        
        W3a2
      - W3b
        W3b1
    - W4
      - W4a
    - W5
      - W5a
        W5a1
        W5a1a
        W5a1a1
        W5a1a1a
        
        W5a2
      - W5b
    - W6
      - C16192T
        W6a
        
        W6b
      - W6c
    - W7

References[]

^ ^a ^b Soares, Pedro; Luca Ermini; Noel Thomson; Maru Mormina; Teresa Rito; Arne Röhl; Antonio Salas; Stephen Oppenheimer; Vincent Macaulay; Martin B. Richards (4 Jun 2009). "Supplemental Data Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics. 84 (6): 82–93. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
^ ^a ^b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.
^ Petraglia, Michael D.; Allchin, Bridget (2007). The Evolution and History of Human Populations in South Asia: Inter-disciplinary Studies in Archaeology, Biological Anthropology, Linguistics and Genetics. Springer Science & Business Media. p. 237. ISBN 978-1-4020-5562-1.
^ Meit Metspalu et al., Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genetics, 2004
^ Asmahan Bekada; Lara R. Arauna; Tahria Deba; Francesc Calafell; Soraya Benhamamouch; David Comas (September 24, 2015). "Genetic Heterogeneity in Algerian Human Populations". PLOS ONE. 10 (9): e0138453. Bibcode:2015PLoSO..1038453B. doi:10.1371/journal.pone.0138453. PMC 4581715. PMID 26402429.; S5 Table
^ Sardana A Fedorova, Maere Reidla, Ene Metspalu, et al., "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia." BMC Evolutionary Biology 2013, 13:127. http://www.biomedcentral.com/1471-2148/13/127
^ Schuenemann, Verena J.; et al. (2017). "Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods". Nature Communications. 8: 15694. Bibcode:2017NatCo...815694S. doi:10.1038/ncomms15694. PMC 5459999. PMID 28556824.
^ Mark Lipson; et al. (2017). "Parallel palaeogenomic transects reveal complex genetic history of early European farmers". Nature. 551 (7680): 368–372. Bibcode:2017Natur.551..368L. doi:10.1038/nature24476. PMC 5973800. PMID 29144465. Retrieved 18 November 2017.
^ Sikora, Martin; Seguin-Orlando, Andaine; Sousa, Vitor C.; Albrechtsen, Anders; Korneliussen, Thorfinn; Ko, Amy; Rasmussen, Simon; Dupanloup, Isabelle; Nigst, Philip R.; Bosch, Marjolein D.; Renaud, Gabriel; Allentoft, Morten E.; Margaryan, Ashot; Vasilyev, Sergey V.; Veselovskaya, Elizaveta V.; Borutskaya, Svetlana B.; Deviese, Thibaut; Comeskey, Dan; Higham, Tom; Manica, Andrea; Foley, Robert; Meltzer, David J.; Nielsen, Rasmus; Excoffier, Laurent; Lahr, Marta Mirazon; Orlando, Ludovic; Willerslev, Eske (2017). "Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers". Science. 358 (6363): 659–662. Bibcode:2017Sci...358..659S. doi:10.1126/science.aao1807. ISSN 0036-8075. PMID 28982795.

External links[]

General
- Mannis van Oven's Phylotree
- The India Genealogical DNA Project
Haplogroup W
- Spread of Haplogroup W, from National Geographic
- mtDNA Haplogroup W Project

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[Soares-1] Soares, Pedro; Luca Ermini; Noel Thomson; Maru Mormina; Teresa Rito; Arne Röhl; Antonio Salas; Stephen Oppenheimer; Vincent Macaulay; Martin B. Richards (4 Jun 2009). "Supplemental Data Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics. 84 (6): 82–93. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.

[vanOven-2] van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.

[3] Petraglia, Michael D.; Allchin, Bridget (2007). The Evolution and History of Human Populations in South Asia: Inter-disciplinary Studies in Archaeology, Biological Anthropology, Linguistics and Genetics. Springer Science & Business Media. p. 237. ISBN 978-1-4020-5562-1.

[4] Meit Metspalu et al., Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genetics, 2004

[Bekada2015-5] Asmahan Bekada; Lara R. Arauna; Tahria Deba; Francesc Calafell; Soraya Benhamamouch; David Comas (September 24, 2015). "Genetic Heterogeneity in Algerian Human Populations". PLOS ONE. 10 (9): e0138453. Bibcode:2015PLoSO..1038453B. doi:10.1371/journal.pone.0138453. PMC 4581715. PMID 26402429.; S5 Table

[Fedorova2013-6] Sardana A Fedorova, Maere Reidla, Ene Metspalu, et al., "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia." BMC Evolutionary Biology 2013, 13:127. http://www.biomedcentral.com/1471-2148/13/127

[7] Schuenemann, Verena J.; et al. (2017). "Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods". Nature Communications. 8: 15694. Bibcode:2017NatCo...815694S. doi:10.1038/ncomms15694. PMC 5459999. PMID 28556824.

[8] Mark Lipson; et al. (2017). "Parallel palaeogenomic transects reveal complex genetic history of early European farmers". Nature. 551 (7680): 368–372. Bibcode:2017Natur.551..368L. doi:10.1038/nature24476. PMC 5973800. PMID 29144465. Retrieved 18 November 2017.

[SikoraSeguin-Orlando2017-9] Sikora, Martin; Seguin-Orlando, Andaine; Sousa, Vitor C.; Albrechtsen, Anders; Korneliussen, Thorfinn; Ko, Amy; Rasmussen, Simon; Dupanloup, Isabelle; Nigst, Philip R.; Bosch, Marjolein D.; Renaud, Gabriel; Allentoft, Morten E.; Margaryan, Ashot; Vasilyev, Sergey V.; Veselovskaya, Elizaveta V.; Borutskaya, Svetlana B.; Deviese, Thibaut; Comeskey, Dan; Higham, Tom; Manica, Andrea; Foley, Robert; Meltzer, David J.; Nielsen, Rasmus; Excoffier, Laurent; Lahr, Marta Mirazon; Orlando, Ludovic; Willerslev, Eske (2017). "Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers". Science. 358 (6363): 659–662. Bibcode:2017Sci...358..659S. doi:10.1126/science.aao1807. ISSN 0036-8075. PMID 28982795.

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