Haplogroup C (mtDNA)
Haplogroup C | |
---|---|
Possible time of origin | 36,473.3 (SD 7392.0) years[1] |
Coalescence age | 27,370 (95% CI 19,550 <-> 35,440) ybp[2] 23,912.2 (SD 4780.8) years[1] 21,700 (95% CI 19,200 <-> 24,400) ybp[3] |
Possible place of origin | Central Asia |
Ancestor | CZ |
Descendants | C1, C4, C5, C7 |
Defining mutations | 489 10400 14783 15043[4] |
In human mitochondrial genetics, Haplogroup C is a human mitochondrial DNA (mtDNA) haplogroup.
Origin[]
Haplogroup C is believed to have arisen somewhere between the Caspian Sea and Lake Baikal some 24,000 years before present. It is a descendant of the haplogroup M. Haplogroup C shares six mutations downstream of the MRCA of haplogroup M with haplogroup Z and five mutations downstream of the MRCA of haplogroup M with other members of haplogroup M8. This macro-haplogroup is known as haplogroup M8'CZ or simply as haplogroup M8.
Distribution[]
Haplogroup C is found in Northeast Asia[5] (including Siberia) and the Americas. In Eurasia, Haplogroup C is especially frequent among populations of arctic Siberia, such as Nganasans, Dolgans, Yakuts, Evenks, Evens, Yukaghirs, and Koryaks.[6][7][8] Haplogroup C is one of five mtDNA haplogroups found in the indigenous peoples of the Americas,[5] the others being A, B, D, and X. The subclades C1b, C1c, C1d, and C4c are found in the first people of the Americas. C1a is found only in Asia.
In 2010, Icelandic researchers discovered C1e lineage in their home country, estimating an introduction date of year 1700 AD or earlier, indicating a possible introduction during the Viking expeditions to the Americas. A Native American origin for this C1e lineage is likely, but the researchers note that a European or Asian one cannot be ruled out.[9][10][11]
In 2014, a study discovered a new mtDNA subclade C1f from the remains of 3 people found in north-western Russia and dated to 7,500 years ago. It has not been detected in modern populations. The study proposed the hypothesis that the sister C1e and C1f subclades had split early from the most recent common ancestor of the C1 clade and had evolved independently. Subclade C1e had a northern European origin. Iceland was settled by the Vikings 1,130 years ago and they had raided heavily into western Russia, where the sister subclade C1f is now known to have resided. They proposed that both subclades were brought to Iceland through the Vikings, however C1e went extinct on mainland northern Europe due to population turnover and its small representation, and subclade C1f went extinct completely.[12]
In 2015, a study conducted in the Aconcagua mummy identified its mtDNA lineage belongs to the subclade C1bi, which contains 10 distinct mutations from C1b.[13]
Table of Frequencies by ethnic group[]
Population | Frequency | Count | Source | Subtypes |
---|---|---|---|---|
Evenks (Stony Tunguska) | 0.769 | 39 | Duggan 2013 | C4a2=7, C4a1c=6, C4b1=5, C5d1=4, C4b=3, C4b3=3, C4a1c1a=1, C5b1b=1 |
Evenk | 0.718 | 71 | Starikovskaya 2005 | C(xC1, C5)=41, C5=10 |
Yukaghir | 0.670 | 100 | Volodko 2008 | C(xC1, C5)=54, C5=13 |
Evenk (East) | 0.644 | 45 | Derenko 2007 | C(xC1, C5)=17, C5=12 |
Tofalar | 0.621 | 58 | Derenko 2003 | C(xC1, C5)=31, C5=5 |
Evens (Sebjan) | 0.556 | 18 | Duggan 2013 | C4b=6, C4a1c=3, C5b1b=1 |
Yukaghirs | 0.550 | 20 | Duggan 2013 | C4a1c=4, C4b3a=2, C4b7=2, C4a2=1, C5a2=1, C5d1=1 |
Yukaghirs (Yakutia) | 0.545 | 22 | Fedorova 2013 | C4b3a=5, C5d1=3, C4a1c=1, C4a2=1, C4b1=1, C5a2a=1 |
Evens (Tompo) | 0.519 | 27 | Duggan 2013 | C4a1c=6, C4a2=3, C4b=2, C4b1=2, C5d1=1 |
Nganasans | 0.513 | 39 | Volodko 2008 | C(xC1, C5)=12, C5=8 |
Tozhu Tuvans | 0.479 | 48 | Derenko 2003 | C(xC1, C5)=16, C5=7 |
Evenks (Yakutia) | 0.472 | 125 | Fedorova 2013 | C4b1=13, C4a1c=11, C4b9=9, C4a2=8, C4b=5, C5b1b=4, C5a2=3, C5d1=2, C4a1=1, C4a1d=1, C4b3a=1, C5a1=1 |
Tuvans | 0.472 | 231 | Derenko 2000 | C(xC1, C5)=88, C5=21 |
Yakut | 0.469 | 254 | Derenko 1997 | C(xC1, C5)=95, C5=24 |
Evens (Berezovka) | 0.467 | 15 | Duggan 2013 | C4b3a=4, C4b=1, C4b1=1, C4b7=1 |
Evenk (West) | 0.466 | 73 | Derenko 2007 | C(xC1, C5)=29, C5=5 |
Evenks (Taimyr) | 0.458 | 24 | Duggan 2013 | C4a1c=5, C4b1=4, C4a1c1a=1, C4a2=1 |
Yakut (Central) | 0.457 | 164 | Fedorova 2013 | C4a1c=16, C4a2=14, C5b1b=13, C4b1=8, C4a1d=7, C4b=4, C4b1a=3, C5a1=3, C4a1=2, C5b1a=2, C4b3a=1, C5a2=1, C7a1c=1 |
Evens (Yakutia) | 0.457 | 105 | Fedorova 2013 | C4a1c=15, C5d1=11, C4a2=4, C4b3a=3, C4b1=2, C4b7=2, C4b9=2, C4b=2, C5a1=2, C7a1c=2, C4b1a=1, C4b2=1, C5a2a=1 |
Evenks () | 0.413 | 46 | Fedorova 2013 | C4a2=10, C4b1=3, C4a1c=2, C4a1d=1, C4b1a=1, C5a2=1, C7a1c=1 |
Yakut (Northern) | 0.405 | 148 | Fedorova 2013 | C4a1c=17, C4b1=16, C4a2=11, C5b1a=4, C5b1b=4, C4b9=3, C4b=2, C5a1=2, C5d1=1 |
Koryaks | 0.400 | 15 | Duggan 2013 | C4b=3, C5a2=3 |
Dolgans | 0.390 | 154 | Fedorova 2013 | C4a1c=33, C4b1=9, C5b1b=5, C4b3a=3, C4a2=2, C4b1a=2, C5b1a=2, C4b8=1, C4b=1, C5d1=1, C7a1c=1 |
Even | 0.377 | 191 | Derenko 1997 | C(xC1, C5)=50, C5=22 |
Koryak | 0.368 | 182 | Derenko 1997 | C(xC1, C5)=39, C5=28 |
Yakut (Vilyuy) | 0.360 | 111 | Fedorova 2013 | C4a1c=14, C4a2=10, C4b=5, C4b1=4, C4b1a=2, C5a2=2, C5b1b=2, C4a1=1 |
Evens (Kamchatka) | 0.333 | 39 | Duggan 2013 | C4b1=6, C4b3a=3, C4a1c=2, C5a2=1, C5d1=1 |
Altai-Kizhi | 0.322 | 90 | Derenko 2007 | C(xC1, C5)=21, C5=8 |
Chuvantsi | 0.313 | 32 | Volodko 2008 | C(xC1, C5)=10 |
Oroqen | 0.295 | 44 | Kong 2003 | C(xC1, C5)=9, C5=4 |
Teleut | 0.283 | 53 | Derenko 2007 | C(xC1, C5)=11, C5=4 |
Evens (Sakkyryyr) | 0.261 | 23 | Duggan 2013 | C4a1c=2, C4b=2, C4a1d=1, C4b1=1 |
Udegey | 0.226 | 31 | Duggan 2013 | C4b1=6, C4a1d=1 |
Mongolian (Ulaanbaatar) | 0.213 | 47 | Jin 2009 | C=10 |
Buryat | 0.212 | 419 | Derenko 2000 | C(xC1, C5)=66, C1=3, C5=20 |
Khakassian | 0.208 | 110 | Derenko 2003 | C(xC1, C5)=28, C5=2 |
Barghut | 0.201 | 149 | Derenko 2012 | C4a1a1=6, C4a1a2=3, C4a1b2=3, C4a2a1=2, C4b1a=2, C4b1=2, C4=2, C5b=2, C4a1a=1, C4a1a1a2=1, C4a1a2a2=1, C4a2a2=1, C5a1=1, C5a2=1, C5b1a=1, C7=1 |
Tubalar | 0.194 | 72 | Starikovskaya 2005 | C(xC1, C5)=12, C5=2 |
Altaian | 0.191 | 110 | Derenko 2003 | C(xC1, C5)=21 |
Evenks () | 0.190 | 21 | Duggan 2013 | C4a2=2, C4b1=1, C5a2=1 |
Udege | 0.174 | 46 | Starikovskaya 2005 | C(xC1, C5)=8 |
Mongolian (Ulaanbaatar) | 0.170 | 47 | Derenko 2007 | C4=4, C*(xC1,C4,C5)=3, C5=1 |
0.169 | 71 | Derenko 2007 | C(xC1, C5)=10, C5=2 | |
Mongolian | 0.153 | 150 | Kolman 1998 | C(xC1, C5)=18, C1=2, C5=3 |
Negidal | 0.152 | 33 | Starikovskaya 2005 | C(xC1, C5)=3, C5=2 |
Kyrgyz (Kyzylsu) | 0.145 | 138 | Guo 2020 | C=20 |
Kyrgyz | 0.140 | 200 | Comas 1998 | C(xC1, C5)=18, C1=1, C5=9 |
Ulch | 0.138 | 87 | Starikovskaya 2005 | C(xC1, C5)=6, C1=1, C5=5 |
Turkmen | 0.135 | 178 | Malyarchuk 2002 | C(xC1, C5)=14, C5=10 |
Chukchi | 0.132 | 417 | Starikovskaya 1998 | C(xC1, C5)=27 C5=28 |
Kazakh (Xinjiang) | 0.132 | 53 | Yao 2004 | C(xC1, C5)=5 C5=2 |
Itelmen | 0.130 | 46 | Shchurr 1999 | C5=6 |
Shor | 0.122 | 82 | Derenko 2007 | C(xC1, C5)=9 C5=1 |
Orok | 0.115 | 61 | Bermisheva 2005 | C1=7 |
Kyrgyz (Taxkorgan) | 0.103 | 68 | Peng 2017 | C4=6, C5=1 |
Thai | 0.100 | 40 | Jin 2009 | C=4 |
Nanai | 0.094 | 85 | Tamm 2007 | C(xC1, C5)=5, C1=1, C5=2 |
Kazakh | 0.086 | 511 | Comas 1998 | C(xC1, C5)=32, C1=4, C5=8 |
Mongolian (Inner Mongolia) | 0.083 | 97 | Kong 2004 | C(xC1, C5)=5 |
Altaian (Kazakhstan) | 0.082 | 98 | Derenko 2009 | C(xC1, C5)=8 |
Kyrgyz (Artux) | 0.074 | 54 | Peng 2017 | C4=4 |
Tajik | 0.073 | 82 | Derenko 2007 | C(xC1, C5)=6 |
Sarikoli | 0.070 | 86 | Peng 2017 | C4a1a+A14878G=2, C4a1=2, C4b1=1, C4+T152C!+T4742C+T8602C=1 |
Daur | 0.066 | 45 | Kong 2003 | C(xC1, C5)=2, C1=1 |
Uyghur (Xinjiang) | 0.064 | 47 | Yao 2004 | C(xC1, C5)=3 |
Uzbek | 0.061 | 130 | Quintana-Murci 2004 | C(xC1, C5)=6, C5=2 |
Vietnamese | 0.048 | 42 | Jin 2009 | C=2 |
Han Chinese | 0.045 | 1930 | Horai 1996 | C(xC1, C5)=72, C5=15 |
Thai | 0.034 | 552 | Matspalu 2004 | C(xC1, C5)=19 |
Korean (mostly Ulsan) | 0.030 | 1094 | Jeon 2020 | C=33 |
Manchu | 0.025 | 40 | Jin 2009 | C=1 |
Korean | 0.024 | 694 | Lee 2006 | C=17 |
Korean (China) | 0.020 | 51 | Jin 2009 | C=1 |
Korean (Korea) | 0.016 | 185 | Jin 2009 | C=3 |
Korean | 0.015 | 537 | Tanaka 2004 | C5=4, C(xC1,C5)=4 |
Korean | 0.010 | 103 | Derenko 2007 | C(xC1,C4,C5)=1 |
Eskimo | 0.008 | 254 | Starikovskaya 1998 | C(xC1, C5)=2 |
Japanese | 0.005 | 1312 | Tanaka 2004 | C1=4, C5=1, C(xC1,C5)=1 |
Japanese (Tokyo) | 0.000 | 118 | Zheng 2011 | - |
Ainu | 0.000 | 51 | Horai 1996 | - |
Nivkh | 0.000 | 38 | Duggan 2013 | - |
Han (Beijing) | 0.000 | 40 | Jin 2009 | - |
Nivkh | 0.000 | 56 | Starikovskaya 2005 | - |
Subclades[]
Tree[]
This phylogenetic tree of haplogroup C subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[4] and subsequent published research.
- CZ
- C - Russia (Bashkortostan[3]), India
- C1 - Paraguay (Alto Parana[14]), ancient DNA from specimen I0061 (from Yuzhniy Oleni Ostrov, Lake Onega, Russia, 7450 - 6950 ybp)
- C1a
- C1b
- C1b*
- C1b1
- C1b1*
- C1b1a
- C1b1a* – Mexican American
- C1b1a1 – Mexican American
- C1b1b – Native American, Mexican American
- C1b2
- C1b2* – Peru, Paraguay
- C1b2a – Peru
- C1b2b – Colombia
- C1b2c
- C1b2c* – USA, Puerto Rico, Paraguay, Spain
- C1b2c1 – Paraguay
- C1b3
- C1b3* – Peru
- C1b3a
- C1b3a* – Peru
- C1b3a1 – Argentina
- C1b4 – Ecuador, Peru, USA
- C1b5
- C1c
- C1c1
- C1c2
- C1d – Argentina (Buenos Aires[20]), Colombia (Boyacá[20]), Mexico (Tamaulipas,[20] Guanajuato,[20] Chihuahua,[20] etc.), United States (Mexican Americans[21]), Canada (Shuswap[22])
- C1e – Iceland
- C1f – Pamiri Tajik (Gorno-Badakhshan),[23][3] India (Marathi),[3] Scotland, Italy, Mesolithic NW Russia
- C1g – Mesolithic NW Russia (Karelia)[24]
- C4 – Upper Palaeolithic (14050 - 13770 ybp) Ust-Kyakhta (Buryatia), Late Neolithic-Bronze Age Irkutsk Oblast,[25][26] Late Neolithic-Iron Age Yakutia,[25] Tubalar (Ederbes), Todzhin (Toora-Hem,[27] Iiy,[27] Adir-Kezhig[27]), Yukaghir (Andrushkino[27]), Yukaghir/Chuvan (Markovo[27]), Russian,[2] Myanmar
- C4a'b'c - Irkutsk Oblast (6815 ybp[3]), India (Jenu Kuruba[28])
- C4a – China (Guangdong,[3] Han from Beijing)
- C4a1 – Tashkurgan (Kyrgyz, Sarikoli, Wakhi),[23] Czech Republic,[29] Denmark[29]
- C4a1a – Korea,[3] China, Uyghur, Buryat (South Siberia[2]), Denmark, Sweden, France, Scotland, Canada
- C4a1a1
- C-T195C! – Ireland, Scotland, England, USA, Hungary (Szeged region[32]), Poland, Belarus,[33] Russia (Russian,[2] Buryat), Turkey, Pakistan (Hazara), India (Jammu and Kashmir), China (Bargut and Mongol in Inner Mongolia, etc.), Korea
- C4a1a2 – China
- C4a1a2a – China (Han from Ili, Han from Henan, etc.)
- C4a1a2b
- C4a1a2b1 - China
- C4a1a2b2 - Uyghur
- C4a1a3 – Bronze Age Irkutsk Oblast (Ust'-Belaya, Khaptsagai, Silinskij, Chastaja Padi), Russian (Kemerovo Oblast[3]), Koryak,[27] Yukaghir,[6][7] Yakut,[7] Evenk (Nyukzha,[7] Chumikan,[27] Nelkan/Dzhigda[27]), Even (Sakkyryyr,[7] Sebjan,[7] Tompo,[7] Markovo,[27] Kamchatka[7]), Udinsk Buryat (Kushun[27]), Todzhin (Toora-Hem,[27] Adir-Kezhig[27]), Altai Kizhi,[2] Iran (Qashqai[34]), Sweden
- C4a1a4 – Buryat,[2] Kazakhstan
- C4a1a2 – China
- C4a1a5 – Teleut,[2] Ladakh
- C4a1a6
- C4a1a7 - Denmark[39]
- C4a1b – China, Thailand (Palaung[40])
- C4a1c - Russia (Bashkortostan,[33] Adygei), Iran (Azerbaijanian[34]), China (Xibo)
- C4a1a – Korea,[3] China, Uyghur, Buryat (South Siberia[2]), Denmark, Sweden, France, Scotland, Canada
- C4a2
- C4a2a – Yakut,[7] Evenk (Chumikan[27])
- C4a2a1 – Bronze Age (2275 - 2040 cal BC) Irkutsk Oblast (specimen irk076 from burial 3 at the Shamanka 2 site, South Baikal),[25][3] Shor,[2] Chelkan, Teleut, Altai Kizhi,[2] Yakut,[7][16] Kazakh, Ket,[41][42][27] Evenk (Stony Tunguska,[7] Taimyr[7]), Buryat (Irkutsk Oblast,[35] Inner Mongolia[35]), China, Korea
- C4a2a1a – Yukaghir,[6][7] Yakut,[7] Evenk (,[7] Iyengra,[7] Nelkan/Dzhigda[27]), Even (Tompo[7])
- C4a2a1b – Evenk[43][15] (Nyukzha[7]), Yakut[7]
- C4a2a1b1 - Evenk (Nyukzha[7])
- C4a2a1c - China (Zhejiang,[3] Uyghurs[3]), Buryat,[2] Todzhin (Iiy[27]), Karanogay (Dagestan[3])
- C4a2a1d - Uyghurs
- C4a2a1e - Bargut (Inner Mongolia[2]), Buryat (Irkutsk Oblast[35])
- C4a2a1f - Buryat (South Siberia,[2] Irkutsk Oblast[35])
- C4a2a1g - Ket[27]
- C4a2a1 – Bronze Age (2275 - 2040 cal BC) Irkutsk Oblast (specimen irk076 from burial 3 at the Shamanka 2 site, South Baikal),[25][3] Shor,[2] Chelkan, Teleut, Altai Kizhi,[2] Yakut,[7][16] Kazakh, Ket,[41][42][27] Evenk (Stony Tunguska,[7] Taimyr[7]), Buryat (Irkutsk Oblast,[35] Inner Mongolia[35]), China, Korea
- C4a2b – Tibet, Korea[3]
- C4a2c – Bargut (Inner Mongolia)[2]
- C4a2a – Yakut,[7] Evenk (Chumikan[27])
- C4a1 – Tashkurgan (Kyrgyz, Sarikoli, Wakhi),[23] Czech Republic,[29] Denmark[29]
- C4b – Yukaghir,[6] Altai Kizhi,[2] Ukraine, Slovakia
- C4c – Ijka[45]
- C4a – China (Guangdong,[3] Han from Beijing)
- C4-T152C! – Russia (Bashkortostan[3]), England[29]
- C4-T152C!-A12780G - Uyghur
- C4d – Turkey, Tibet (Chamdo, Nyingchi, Shannan, Lhoba[47]), Thailand (Khon Mueang from Chiang Mai Province[40]), Han from Beijing
- C4-T152C!-T4742C - Altai Republic (ancient DNA), Uyghur
- C4-T152C!-T4742C-T16093C - Kyrgyz (Kyrgyzstan[19]), Tibet (Nyingchi)
- C4-T152C!-T4742C-T8602C - Sarikoli (Tashkurgan),[23] Burusho (Pakistan[17])
- C4-T152C!-T4742C-T8602C-G11176A - Pamiri (Gorno-Badakhshan Autonomous Region of Tajikistan[23])
- C4e – Teleut,[2] Shor[2]
- C4-T152C!-A12780G - Uyghur
- C4a'b'c - Irkutsk Oblast (6815 ybp[3]), India (Jenu Kuruba[28])
- C5 – India
- C5a – Azeri
- C5a1 – Bargut (Inner Mongolia),[2] Buryat (Irkutsk Oblast[35]), Xibo (HGDP), Kazakhstan
- C5a1a - Khanty,[16] Altai Kizhi[2]
- C5a1b - Even (Severo-Evensk district[2]), Ulchi[15]
- C5a1c - Yakut, Khamnigan (South Siberia[2])
- C5a1d - Buryat (South Siberia,[2] Inner Mongolia[35])
- C5a1e - Uyghur
- C5a1f - Uyghur
- C5a2
- C5a1 – Bargut (Inner Mongolia),[2] Buryat (Irkutsk Oblast[35]), Xibo (HGDP), Kazakhstan
- C5b – Poland[2][48]
- C5b1 – Buryat (South Siberia[2]), Tofalar,[37] Todjin,[37] Tuvan,[37] Sojot,[37] Ladakh, Japan
- C5b1a – Evenk (Central Siberia[2])
- C5b1a1 – Nganasan,[15] Yakut,[7] Buryat (South Siberia[2]), Khamnigan (South Siberia[2]), Kyrgyz (Tashkurgan[23])
- C5b1a2 - Altai Kizhi (South Siberia[2]), Irtysh-Barabinsk Tatar (Novosibirsk Oblast)
- C5b1b – Khakas[37]
- C5b1a – Evenk (Central Siberia[2])
- C5b1 – Buryat (South Siberia[2]), Tofalar,[37] Todjin,[37] Tuvan,[37] Sojot,[37] Ladakh, Japan
- C5-T16093C – Japan (Aichi), Han (Beijing)
- C5a – Azeri
- C7 – South Korea (Seoul),[2] China,[50] Taiwan (Hakka), Thailand (Khon Mueang in Chiang Rai Province, Chiang Mai Province, and Lamphun Province[40]), Vietnam (Kinh, Tay, Jarai)
- C7a – Han (Beijing, Yunnan, Denver, etc.),[51] Uyghur, Taiwan (Paiwan, Minnan), Lahu, Thailand (incl. Urak Lawoi, Lao Isan in Chaiyaphum Province, Khon Mueang in Lamphun Province, Khon Mueang in Lampang Province, Kaleun in Nakhon Phanom Province, Black Tai in Loei Province, Phuan in Suphan Buri Province[40]), Vietnam (Hani, Yao, Gelao)
- C7a1 – China, Taiwan (Makatao), USA (Han Chinese in Denver), Korea
- C7a1a – Thailand (Mon in Lopburi Province[40])
- C7a1b – Northern Thailand (Tai Lue[52]), Vietnam (Nung)
- C7a1c – Uyghurs, Chinese (Fengcheng,[53] Shandong,[3] Fujian,[3] Taixing, etc.), Taiwan, Korea,[3] Vietnam
- C7a1d – Wancho[28]
- C7a1f – Thailand (Karen)
- C7a1f1 – Thailand (Karen, Shan, Khon Mueang from Mae Hong Son Province, Mon from Kanchanaburi Province)
- C7a1f1a – Thailand (S'gaw Karen, Khon Mueang in Chiang Rai Province[40])
- C7a1f1 – Thailand (Karen, Shan, Khon Mueang from Mae Hong Son Province, Mon from Kanchanaburi Province)
- C7a2 – China,[54] Dai, Laos (Lao in Luang Prabang[40]), Thailand (Khon Mueang in Chiang Mai Province, Khon Mueang in Chiang Rai Province, Lao Isan in Roi Et Province, Phutai in Sakon Nakhon Province, Mon in Nakhon Ratchasima Province[40]), Myanmar (Yangon)
- C7a3
- C7a4
- C7a5
- C7a6
- C7a1 – China, Taiwan (Makatao), USA (Han Chinese in Denver), Korea
- C7-A16051G – Bargut (Inner Mongolia)[2]
- C7b – Gallong,[28] Naxi, Ukraine, Moldova, Austria
- C7c – Korea
- C7d – Taiwan (Hakka), Vietnam (Vietnamese), Thailand (Khon Mueang in Mae Hong Son Province, Lao Isan in Roi Et Province), Cambodia (Kampong Cham)
- C7e – Cambodia (Takéo), Thailand (Khmer in Surin Province)
- C7a – Han (Beijing, Yunnan, Denver, etc.),[51] Uyghur, Taiwan (Paiwan, Minnan), Lahu, Thailand (incl. Urak Lawoi, Lao Isan in Chaiyaphum Province, Khon Mueang in Lamphun Province, Khon Mueang in Lampang Province, Kaleun in Nakhon Phanom Province, Black Tai in Loei Province, Phuan in Suphan Buri Province[40]), Vietnam (Hani, Yao, Gelao)
- C1 - Paraguay (Alto Parana[14]), ancient DNA from specimen I0061 (from Yuzhniy Oleni Ostrov, Lake Onega, Russia, 7450 - 6950 ybp)
- C - Russia (Bashkortostan[3]), India
Popular culture[]
In his popular book The Seven Daughters of Eve, Bryan Sykes named the originator of this mtDNA haplogroup Chochmingwu.
See also[]
Wikimedia Commons has media related to Haplogroup C (mtDNA). |
- Genealogical DNA test
- Genetic genealogy
- Human mitochondrial genetics
- Population genetics
- Human mitochondrial DNA haplogroups
- Indigenous American genetic studies
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups | |||||||||||||||||||||||||||||||||||||||
Mitochondrial Eve (L) | |||||||||||||||||||||||||||||||||||||||
L0 | L1–6 | ||||||||||||||||||||||||||||||||||||||
L1 | L2 | L3 | L4 | L5 | L6 | ||||||||||||||||||||||||||||||||||
M | N | ||||||||||||||||||||||||||||||||||||||
CZ | D | E | G | Q | O | A | S | R | I | W | X | Y | |||||||||||||||||||||||||||
C | Z | B | F | R0 | pre-JT | P | U | ||||||||||||||||||||||||||||||||
HV | JT | K | |||||||||||||||||||||||||||||||||||||
H | V | J | T |
References[]
This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: See "broken" references! (January 2021) |
- ^ Jump up to: a b Behar et al., 2012b
- ^ Jump up to: a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg Derenko,M., Malyarchuk,B., Grzybowski,T., Denisova,G., Rogalla,U., Perkova,M., Dambueva,I., and Zakharov,I., "Origin and post-glacial dispersal of mitochondrial DNA haplogroups C and D in northern Asia." PLoS ONE 5 (12), E15214 (2010).
- ^ Jump up to: a b c d e f g h i j k l m n o p q r s YFull MTree 1.02.7045 (as of January 11, 2021)
- ^ Jump up to: a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.
- ^ Jump up to: a b Haplogroup C.
- ^ Jump up to: a b c d e f g h i j k l m n o p q r Volodko, Natalia V.; Starikovskaya, Elena B.; Mazunin, Ilya O.; et al. (2008). "Mitochondrial Genome Diversity in Arctic Siberians, with Particular Reference to the Evolutionary History of Beringia and Pleistocenic Peopling of the Americas". The American Journal of Human Genetics. 82 (5): 1084–1100. doi:10.1016/j.ajhg.2008.03.019. PMC 2427195. PMID 18452887.
- ^ Jump up to: a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at Duggan, AT; Whitten, M; Wiebe, V; Crawford, M; Butthof, A; et al. (2013). "Investigating the Prehistory of Tungusic Peoples of Siberia and the Amur-Ussuri Region with Complete mtDNA Genome Sequences and Y-chromosomal Markers". PLOS ONE. 8 (12): e83570. Bibcode:2013PLoSO...883570D. doi:10.1371/journal.pone.0083570. PMC 3861515. PMID 24349531.
- ^ Fedorova, Sardana A; Reidla, Maere; Metspalu, Ene; et al. (2013). "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia". BMC Evolutionary Biology. 2013 (13): 127. doi:10.1186/1471-2148-13-127. PMC 3695835. PMID 23782551.
- ^ Sunna Ebenesersdóttir, Sigríður (2010). "A new subclade of mtDNA haplogroup C1 found in icelanders: Evidence of pre-columbian contact?". American Journal of Physical Anthropology. 144 (1): 92–99. doi:10.1002/ajpa.21419. PMID 21069749.
- ^ Vikings brought Amerindian to Iceland 1,000 years ago: study, November 17, 2010
- ^ First Americans 'reached Europe five centuries before Columbus voyages', 16 Nov 2010
- ^ Der Sarkissian, Clio; Brotherton, Paul; Balanovsky, Oleg; Templeton, Jennifer E. L.; Llamas, Bastien; Soubrier, Julien; Moiseyev, Vyacheslav; Khartanovich, Valery; Cooper, Alan; Haak, Wolfgang (2014). "Mitochondrial Genome Sequencing in Mesolithic North East Europe Unearths a New Sub-Clade within the Broadly Distributed Human Haplogroup C1". PLOS ONE. 9 (2): e87612. Bibcode:2014PLoSO...987612D. doi:10.1371/journal.pone.0087612. PMC 3913659. PMID 24503968.
- ^ Gómez-Carballa & Catelli 2015.
- ^ Filipa Simão, Christina Strobl, Carlos Vullo, et al., "The maternal inheritance of Alto Paraná revealed by full mitogenome sequences." FSI Genetics Volume 39, P66-72, March 01, 2019. Published online December 19, 2018. DOI:https://doi.org/10.1016/j.fsigen.2018.12.007
- ^ Jump up to: a b c d e f g Starikovskaya, E.B., Sukernik, R.I., Derbeneva, O.A., Volodko, N.V., Ruiz-Pesini, E., Torroni, A., Brown, M.D., Lott, M.T., Hosseini, S.H., Huoponen, K. and Wallace, D.C., "Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups." Annals of Human Genetics 69 (PT 1), 67-89 (2005).
- ^ Jump up to: a b c d Ingman, M.; Gyllensten, U. (2007). "Rate variation between mitochondrial domains and adaptive evolution in humans". Human Molecular Genetics. 16 (19): 2281–2287. doi:10.1093/hmg/ddm180. PMID 17617636.
- ^ Jump up to: a b Sebastian Lippold; et al. (2014). "Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences". bioRxiv 10.1101/001792.
- ^ Derenko, Miroslava; Malyarchuk, Boris; Grzybowski, Tomasz; et al. (2007). "Phylogeographic Analysis of Mitochondrial DNA in Northern Asian Populations". Am. J. Hum. Genet. 81 (5): 1025–1041. doi:10.1086/522933. PMC 2265662. PMID 17924343.
- ^ Jump up to: a b c Marchi, Nina; Hegay, Tatyana; Mennecier, Philippe; Georges, Myriam; Laurent, Romain; Whitten, Mark; Endicott, Philipp; Aldashev, Almaz; Dorzhu, Choduraa; Nasyrova, Firuza; Chichlo, Boris; Ségurel, Laure; Heyer, Evelyne (2017). "Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations". American Journal of Physical Anthropology. 162 (4): 627–640. doi:10.1002/ajpa.23151. PMID 28158897.
- ^ Jump up to: a b c d e f g U.A. Perego, N. Angerhofer, M. Pala, et al., "The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia." Genome Res. 20 (9), 1174-1179 (2010).
- ^ S. Kumar, C. Bellis, M. Zlojutro, et al., "Large scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins." BMC Evol. Biol. 11 (1), 293 (2011).
- ^ Jump up to: a b R.S. Malhi, J.S. Cybulski, R.Y. Tito, et al., "Brief communication: Mitochondrial haplotype C4c confirmed as a founding genome in the Americas." Am. J. Phys. Anthropol. 141 (3), 494-497 (2010).
- ^ Jump up to: a b c d e Peng, Min-Sheng; Xu, Weifang; Song, Jiao-Jiao; Chen, Xing; Sulaiman, Xierzhatijiang; Cai, Liuhong; Liu, He-Qun; Wu, Shi-Fang; Gao, Yun; Abdulloevich, Najmudinov Tojiddin; Afanasevna, Manilova Elena; Ibrohimovich, Khudoidodov Behruz; Chen, Xi; Yang, Wei-Kang; Wu, Miao; Li, Gui-Mei; Yang, Xing-Yan; Rakha, Allah; Yao, Yong-Gang; Upur, Halmurat; Zhang, Ya-Ping (2018). "Mitochondrial genomes uncover the maternal history of the Pamir populations". European Journal of Human Genetics. 26 (1): 124–136. doi:10.1038/s41431-017-0028-8. PMC 5839027. PMID 29187735.
- ^ Fu, Qiaomei; Posth, Cosimo; Hajdinjak, Mateja; Petr, Martin; Mallick, Swapan; Fernandes, Daniel; Furtwängler, Anja; Haak, Wolfgang; Meyer, Matthias; Mittnik, Alissa; Nickel, Birgit (June 2016). "The genetic history of Ice Age Europe". Nature. 534 (7606): 200–205. Bibcode:2016Natur.534..200F. doi:10.1038/nature17993. hdl:10211.3/198594. ISSN 1476-4687. PMC 4943878. PMID 27135931.
- ^ Jump up to: a b c Kilinc, G.M., Kashuba, N., Yaka, R., Sumer, A.P., Yuncu, E., Shergin, D., Ivanov, G.L., Kichigin, D., Pestereva, K., Volkov, D., Mandryka, P., Kharinskii, A., Tishkin, A., Ineshin, E., Kovychev, E., Stepanov, A., Alekseev, A., Fedoseeva, S.A., Somel, M., Jakobsson, M., Krzewinska, M., Stora, J., and Gotherstrom, A., "Investigating Holocene human population history in North Asia using ancient mitogenomes." Sci Rep 8 (1), 8969 (2018)
- ^ Cite error: The named reference
Yu2020
was invoked but never defined (see the help page). - ^ Jump up to: a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae Dryomov SV, Nazhmidenova AM, Starikovskaya EB, Shalaurova SA, Rohland N, Mallick S, et al. (2021), "Mitochondrial genome diversity on the Central Siberian Plateau with particular reference to the prehistory of northernmost Eurasia." PLoS ONE 16(1):e0244228.https://doi.org/10.1371/journal.pone.0244228
- ^ Jump up to: a b c d e f g h i j k Chandrasekar, A; Kumar, S; Sreenath, J; Sarkar, BN; Urade, BP; et al. (2009). "Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor". PLOS ONE. 4 (10): e7447. Bibcode:2009PLoSO...4.7447C. doi:10.1371/journal.pone.0007447. PMC 2757894. PMID 19823670.
- ^ Jump up to: a b c d e Cite error: The named reference
FTDNA
was invoked but never defined (see the help page). - ^ Cite error: The named reference
Bhandari2015
was invoked but never defined (see the help page). - ^ Mielnik-Sikorska, M; Daca, P; Malyarchuk, B; Derenko, M; Skonieczna, K; et al. (2013). "The History of Slavs Inferred from Complete Mitochondrial Genome Sequences". PLOS ONE. 8 (1): e54360. Bibcode:2013PLoSO...854360M. doi:10.1371/journal.pone.0054360. PMC 3544712. PMID 23342138.
- ^ Malyarchuk,B., Derenko,M., Denisova,G., et al., "Whole mitochondrial genome diversity in two Hungarian populations." Mol. Genet. Genomics (2018).
- ^ Jump up to: a b Cite error: The named reference
Pankratov2016
was invoked but never defined (see the help page). - ^ Jump up to: a b c d Derenko, M; Malyarchuk, B; Bahmanimehr, A; Denisova, G; Perkova, M; et al. (2013). "Complete Mitochondrial DNA Diversity in Iranians". PLOS ONE. 8 (11): e80673. Bibcode:2013PLoSO...880673D. doi:10.1371/journal.pone.0080673. PMC 3828245. PMID 24244704.
- ^ Jump up to: a b c d e f g h i j k Cite error: The named reference
Derenko2017
was invoked but never defined (see the help page). - ^ Rieux, Adrien; Eriksson, Anders; Li, Mingkun; et al. (2014). "Improved Calibration of the Human Mitochondrial Clock Using Ancient Genomes". Mol Biol Evol. 31 (10): 2780–92. doi:10.1093/molbev/msu222. PMC 4166928. PMID 25100861.
- ^ Jump up to: a b c d e f M. V. Derenko, T. Grzybowski, B. A. Malyarchuk, et al., "Diversity of Mitochondrial DNA Lineages in South Siberia." Annals of Human Genetics (2003) 67,391–411.
- ^ Dryomov, S.V., Starikovskaya, E.B., Nazhmidenova, A.M. et al. Genetic legacy of cultures indigenous to the Northeast Asian coast in mitochondrial genomes of nearly extinct maritime tribes. BMC Evol Biol 20, 83 (2020). https://doi.org/10.1186/s12862-020-01652-1
- ^ Klunk, J., Duggan, A.T., Redfern, R., et al., "Genetic resiliency and the Black Death: No apparent loss of mitogenomic diversity due to the Black Death in medieval London and Denmark." Am. J. Phys. Anthropol. (2019).
- ^ Jump up to: a b c d e f g h Kutanan, Wibhu; Kampuansai, Jatupol; Srikummool, Metawee; Kangwanpong, Daoroong; Ghirotto, Silvia; Brunelli, Andrea; Stoneking, Mark (2016). "Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai–Kadai languages". Hum Genet. 136 (1): 85–98. doi:10.1007/s00439-016-1742-y. PMC 5214972. PMID 27837350.
- ^ O. A. Derbeneva, E. B. Starikovskaya, N. V. Volodko, D. C. Wallace, and R. I. Sukernik, "Mitochondrial DNA Variation in the Kets and Nganasans and Its Implications for the Initial Peopling of Northern Eurasia." Russian Journal of Genetics, Vol. 38, No. 11, 2002, pp. 1316–1321. Translated from Genetika, Vol. 38, No. 11, 2002, pp. 1554–1560.
- ^ Kristiina Tambets, Bayazit Yunusbayev, Georgi Hudjashov, et al., "Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations." Genome Biology (2018) 19:139. https://doi.org/10.1186/s13059-018-1522-1
- ^ Jump up to: a b Ingman, M.; Kaessmann, H.; Paabo, S.; Gyllensten, U. (2000). "Mitochondrial genome variation and the origin of modern humans". Nature. 408 (6813): 708–713. Bibcode:2000Natur.408..708I. doi:10.1038/35047064. PMID 11130070. S2CID 52850476.
- ^ Cite error: The named reference
Kang2013
was invoked but never defined (see the help page). - ^ Tamm, E; Kivisild, T; Reidla, M; Metspalu, M; Smith, DG; Mulligan, CJ; Bravi, CM; Rickards, O; Martinez-Labarga, C; Khusnutdinova, EK; Fedorova, SA; Golubenko, MV; Stepanov, VA; Gubina, MA; Zhadanov, SI; Ossipova, LP; Damba, L; Voevoda, MI; Dipierri, JE; Villems, R; Malhi, RS (2007). "Beringian standstill and spread of Native American founders". PLOS ONE. 2 (9): e829. Bibcode:2007PLoSO...2..829T. doi:10.1371/journal.pone.0000829. PMC 1952074. PMID 17786201.
- ^ Jump up to: a b c d e Cite error: The named reference
HooshiarKashani2012
was invoked but never defined (see the help page). - ^ Cite error: The named reference
Kang2016
was invoked but never defined (see the help page). - ^ Malyarchuk,B., Litvinov,A., Derenko,M., Skonieczna,K., Grzybowski,T., Grosheva,A., Shneider,Y., Rychkov,S. and Zhukova,O., "Mitogenomic diversity in Russians and Poles." Forensic Sci Int Genet 30, 51-56 (2017).
- ^ Cite error: The named reference
Liu2012
was invoked but never defined (see the help page). - ^ Jiang,C., Cui,J., Liu,F., Gao,L., Luo,Y., Li,P., Guan,L. and Gao,Y., "Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia." PLoS ONE 9 (1), E87775 (2014).
- ^ Fuyun Ji, Mark S. Sharpley, Olga Derbeneva, et al., "Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans." PNAS May 8, 2012 109 (19) 7391-7396; https://doi.org/10.1073/pnas.1202484109.
- ^ Kutanan, Wibhu; Kampuansai, Jatupol; Changmai, Piya; et al. (2018). "Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand". Scientific Reports. 8 (1): 1536. Bibcode:2018NatSR...8.1536K. doi:10.1038/s41598-018-20020-0. PMC 5784115. PMID 29367746.
- ^ Kong, Q.P.; Yao, Y.G.; Sun, C.; Bandelt, H.J.; Zhu, C.L.; Zhang, Y.P. (2003). "Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences". Am. J. Hum. Genet. 73 (3): 671–676. doi:10.1086/377718. PMC 1180693. PMID 12870132.
- ^ Zhang,A.M., Bandelt,H.J., Jia,X., Zhang,W., Li,S., Yu,D., Wang,D., Zhuang,X.Y., Zhang,Q., and Yao,Y.G., "Is Mitochondrial tRNA Variant m.593T>C a Synergistically Pathogenic Mutation in Chinese LHON Families with m.11778G>A?" PLoS ONE 6 (10), E26511 (2011).
- ^ Wang, C.Y.; Wang, H.W.; Yao, Y.G.; Kong, Q.P.; Zhang, Y.P. (2007). "Somatic mutations of mitochondrial genome in early stage breast cancer". Int. J. Cancer. 121 (6): 1253–1256. doi:10.1002/ijc.22822. PMID 17514652. S2CID 36734968.
Bibliography[]
- Gómez-Carballa, Alberto; Catelli, Laura (November 12, 2015). "The complete mitogenome of a 500-year-old Inca child mummy". Scientific Reports. 5: 16462. Bibcode:2015NatSR...516462G. doi:10.1038/srep16462. PMC 4642457. PMID 26561991.
External links[]
- General
- Ian Logan's Mitochondrial DNA Site
- Mannis van Oven's Phylotree
- Haplogroup C
- Spread of Haplogroup C, from National Geographic
- Human mtDNA haplogroups